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Trials on veterans suggest ibogaine could provide a new treatment for PTSD

bbc.com

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Re: Trials on veterans suggest ibogaine could provide a new treatment for PTSD

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post #3

It seems strange to me to choose ibogaine when Salvia divinorum seems like it has a similar psychological experience without the physical heart risk.

Or LSD, or magic mushrooms.

I've been assuming it was some sort of profit motive as TX has been pumping money into it. It seems like there might actually be science driven though. For tramatic brain injury combined with ptsd ibogaine causes a release of glial cell factors that help neuroplasticity wire around the damage. Its also horribly unsafe from a cardiac perspective so you would need a constant eeg during therapy driving up prices. So probably a little of the original motivation too.

Re: Trials on veterans suggest ibogaine could provide a new treatment for PTSD

#6
post #3

It seems strange to me to choose ibogaine when Salvia divinorum seems like it has a similar psychological experience without the physical heart risk.

Saliva divinorum is inherently dysphoric due to its agonism of the kappa opiod receptor. For a different cheap legal drug that affects serotonin and the NMDA receptors like ibogaine does, there's always off label use of dextromethorphan (cough medicine)!

Re: Trials on veterans suggest ibogaine could provide a new treatment for PTSD

#8
Only veterans?

I wonder about the editorial choice to use veterans rather than, say, women who have PTSD from assaults, which is a much larger group of people. (Approximately 4% of US men and 8% of US women experience PTSD every year across all reasons like accidents, sexual assaults, combat, etc.)

Presumably this treatment would help everyone? Or is it somehow supporting only vets?

Re: Trials on veterans suggest ibogaine could provide a new treatment for PTSD

#9
post #7
post #3

It seems strange to me to choose ibogaine when Salvia divinorum seems like it has a similar psychological experience without the physical heart risk.

What? These two substances aren't even in the same ballpark.

Maybe I have a liberal view of ballpark sizes but:

https://en.wikipedia.org/wiki/Ibogaine

"The action of ibogaine at the κ-opioid receptor may indeed contribute significantly to the psychoactive effects attributed to ibogaine ingestion; Salvia divinorum, another plant recognized for its strong hallucinogenic properties contains the chemical salvinorin A, which is a highly selective κ-opioid agonist"

Re: Trials on veterans suggest ibogaine could provide a new treatment for PTSD

#10
post #8

Only veterans? I wonder about the editorial choice to use veterans rather than, say, women who have PTSD from assaults, which is a much larger group of people. (Approximately 4% of US men and 8% of US women experience PTSD every year across all reasons like accidents, sexual assaults, combat, etc.) Presumably this treatment would help everyone? Or is it somehow supporting only vets?

Vets kill themselves a lot so I guess it's easier to propose crazier stuff because the alternative is very bad.
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