Earlier quoted context omitted.
If the utility of it was the caffeine, what would the audience for decaf be? It should be plain that the other aspects are also important.
"other aspects" a.k.a. status signalling. Cool kids drink coffee.
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Nuclear receptor 4A1 linked to health effects of coffee: study
91–100 of 127 posts
Re: Nuclear receptor 4A1 linked to health effects of coffee: study
#92Earlier quoted context omitted.
FYI since many people don't know: Decaf isn't zero, it can still be several percentage points. In the US decaf is supposed to be under 3% of regular coffee but it's not commonly tested or enforced, so many types of decaf can be quite a bit higher. Several big cups of decaf can approach the caffeine content of one regular cup.
> Several big cups of decaf can approach the caffeine content of one regular cup Do you have a source for this? Because it doesn't sound right to me. And also, I live in a coffee producing company, work adjacent to the coffee industry, and had a long conversation with someone planning to set up a business exporting green beans to the US, and their beans were getting tested to an extreme degree and being rejected for…
Just Wikipedia. It cites two studies that found values of 8-13 mg and 3-32 mg per decaf cup, compared to regular which is 95-200. https://en.wikipedia.org/wiki/Decaffeination
Re: Nuclear receptor 4A1 linked to health effects of coffee: study
#93Here are more fascinating facts about caffeine and cancer. Caffeine affects the immune system via at least two opposing mechanisms. Mechanism 1: A2A receptor antagonism (immunostimulatory) Tumors and damaged tissues release adenosine, which engages the A2A receptor on immune cells and signals them to stand down. Caffeine antagonizes (i.e., blocks) this receptor. Mechanism 2: Raising intracellular cAMP (immunosuppress…
Would it be tenable to link caffeine as just asking your body (and heart) to work more, trading cancer for heart disease?
Re: Nuclear receptor 4A1 linked to health effects of coffee: study
#94I love coffee. It's good for you, it smells and tastes so good. It wakes you up, and prevents sleepiness after meals. Its stimulant nature is a plus, but not necessarily the main thing.
Unfortunately the most flavorful methods (espresso, french press, moka) also raise your cholesterol. So sadly, no, coffee is not universally "good for you". Filtered coffee methods are though, as the filter absorbs the oils.
The dose makes the poison.
Re: Nuclear receptor 4A1 linked to health effects of coffee: study
#95Here are more fascinating facts about caffeine and cancer. Caffeine affects the immune system via at least two opposing mechanisms. Mechanism 1: A2A receptor antagonism (immunostimulatory) Tumors and damaged tissues release adenosine, which engages the A2A receptor on immune cells and signals them to stand down. Caffeine antagonizes (i.e., blocks) this receptor. Mechanism 2: Raising intracellular cAMP (immunosuppress…
If we wanted to know chatgpt's opinion we'd ask it directly
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Re: Nuclear receptor 4A1 linked to health effects of coffee: study
#96Here are more fascinating facts about caffeine and cancer. Caffeine affects the immune system via at least two opposing mechanisms. Mechanism 1: A2A receptor antagonism (immunostimulatory) Tumors and damaged tissues release adenosine, which engages the A2A receptor on immune cells and signals them to stand down. Caffeine antagonizes (i.e., blocks) this receptor. Mechanism 2: Raising intracellular cAMP (immunosuppress…
On second thought, I will publish something regardless of interest. It will be an "Cancer for Engineers" framework, delivered via free, open-source Custom GPTs and Claude Skills. (Gemini gems are less reliable in our experience.) The goal: to ease engineers into cancer via AI personalized introductory curriculums with varying time commitments to enable deeper independent investigation or fast exits if interest wanes:…
For people questioning why to involve GPT and AI assistants:
GPT and AI assistants cannot be fully trusted, but they can personalize learning.
The chief challenge for the framework/handbook will be resolving how to personalize guidance into cancer research while grounding knowledge in trustworthy sources.
For instance, the framework will anchor abstract, dry biological concepts in personally meaningful tracks. Imagine someone you care about is battling lung cancer — the framework may orient learning around the molecular drivers and signaling pathways at play, or perhaps how to explore the treatment landscape while respecting established practices. If you're fortunate enough to not know someone affected by cancer, GPT can help find a personal angle.
The sheer depth of information is staggering. People devote entire careers to niche specialities, and these experts still don't know everything in their niche because our understanding of human biology and disease is constantly evolving. Adapting depth should also depend on the individual and can only be achieved via AI. Static curriculums do not maximize learning in 2026.
Re: Nuclear receptor 4A1 linked to health effects of coffee: study
#97Here are more fascinating facts about caffeine and cancer. Caffeine affects the immune system via at least two opposing mechanisms. Mechanism 1: A2A receptor antagonism (immunostimulatory) Tumors and damaged tissues release adenosine, which engages the A2A receptor on immune cells and signals them to stand down. Caffeine antagonizes (i.e., blocks) this receptor. Mechanism 2: Raising intracellular cAMP (immunosuppress…
Would it be tenable to link caffeine as just asking your body (and heart) to work more, trading cancer for heart disease?
From what I recall, caffeine is mostly a concern for folks with pre-existing cardiovascular conditions.
Most adults can build tolerance, and I believe some studies are showing potential links between caffeine consumption and positive outcomes.
Of course, things get a little weirder with higher doses, and I am a bit concerned about new methods like pre-workout powder.
Re: Nuclear receptor 4A1 linked to health effects of coffee: study
#98Earlier quoted context omitted.
Yes, I know the four main methods of decaffeination. The haters have gone down this road with me many times. Why can't people just let me drink my decaf? It's like they can't enjoy their caffeine unless everybody does. It's weirdly pushy.
My initial charitable reading -- as someone who sometimes dabbles in decaf -- is that decaffeination has the bad side effect of stripping flavors, and likely many of the other biologically active chemicals. I can see from their further posts that they were more interested in unscientific fear mongering instead. That said, I do think there is some truth that decaf is lacking (including via supercritical CO2) and I won…
> likely many of the other biologically active chemicals.
Do you reckon taking green coffee beans and roasting them til they’re brown right through has any detrimental effect on the biological compounds in the beans?
Re: Nuclear receptor 4A1 linked to health effects of coffee: study
#99Earlier quoted context omitted.
Hey, man, drink what you want. It doesn't change my life in any way, shape, or form. But I have to ask, have you seen the image describing where decaf coffee comes from? https://i.imgur.com/aDt06Lg.png I do find it amusing. But drink your decaf, brother, do what works for you.
What would be a healthy drink that tastes like a (sweet) coffee but without caffeine?
Perhaps try roasted fig coffee substitute? It's definitely not coffee but has enough of the same roasty flavor notes to be passable. With milk and sugar, I probably wouldn't notice it wasn't coffee if I wasn't paying attention.
Re: Nuclear receptor 4A1 linked to health effects of coffee: study
#100Here are more fascinating facts about caffeine and cancer. Caffeine affects the immune system via at least two opposing mechanisms. Mechanism 1: A2A receptor antagonism (immunostimulatory) Tumors and damaged tissues release adenosine, which engages the A2A receptor on immune cells and signals them to stand down. Caffeine antagonizes (i.e., blocks) this receptor. Mechanism 2: Raising intracellular cAMP (immunosuppress…
I'm always up for learning more about everything. Point me in the right direction?
I will aim to put together a Cancer 101 for engineers, not sure how to share. Maybe I'll post here or will post to our biomedical GitHub so it can evolve over time?