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Acetaminophen vs. ibuprofen

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Re: Acetaminophen vs. ibuprofen

#81
post #24

If you don't make a habit of taking either, what actually performs better?

For non-habitual pain relief, combinations outperform either in isolation. Studies show a significant effect, and anecdotally for me it's often the difference between dampening and outright curing a headache. Combo pills are widely available in most countries (branded as Advil Dual Action and Motrin Dual Action in the US), but they're pretty new so consumer awareness isn't yet super high.

Re: Acetaminophen vs. ibuprofen

#82

I lived with an ICU nurse for years and one of the things he emphasized was the risk of acetaminophen overdose. He's more than once treated the liver failure (and death) from it and by his words, it's one of the worse ways to go. The positive of it is it got me in the habit of logging whenever I take it, either in a note on my phone or just a sheet of paper I place on my dresser under the bottle. This helps make sure…

P.S. like someone mentioned in a comment below happened to them, be careful with NSAIDs over the long term. Until recently I took them daily for better part of 3 years. I was recently diagnosed with chronic kidney disease. Can't definitively say causation, but they definitely contributed. They're fine for short term use but can really f$%# you up with long term, daily use.

It is absolutely valid to warn about long term use, and NSAIDs in particular (I was lucky and had a gastroscopy before they'd done any serious damage, but they found significant erosion of my stomach lining due to NSAIDs), but acetaminophen/paracetamol isn't an NSAID (ibuprofen and aspirin, for example, are)

Re: Acetaminophen vs. ibuprofen

#83
For migraines, I take two CVS Migraine about every week to ten days. It's a cocktail of acetaminophen, aspirin and caffeine which tallies to 500 mg of acetaminophen, well under then 4g limit. It's good for four hours but you can only take two per day.

I didn't know about this acetaminophen risk. So I'll be looking for alternatives. Ibuprofen is for inflammation and not headaches. Naproxen is a candidate.

Re: Acetaminophen vs. ibuprofen

#85

I lived with an ICU nurse for years and one of the things he emphasized was the risk of acetaminophen overdose. He's more than once treated the liver failure (and death) from it and by his words, it's one of the worse ways to go. The positive of it is it got me in the habit of logging whenever I take it, either in a note on my phone or just a sheet of paper I place on my dresser under the bottle. This helps make sure…

I'm not disagreeing with you or trying to be disagreeable, but how do people accidentally exceed 3-4 grams daily? That's 6-8 pills!

People who are in a lot of pain and don’t know the risks.

Rationalizations like “they probably put the limit way lower than the real limit so idiots don’t OD themselves, so I can safely take a bit more” become very attractive when you’re in a lot of pain.

Re: Acetaminophen vs. ibuprofen

#86
post #52

Earlier quoted context omitted.

What does ingesting 10g of acetaminophen even look like? I've got to imagine the fatal dose is far, far, far lower with chronic usage. Finding out that people are ingesting grams is profoundly disturbing.

I have taken 4-5g in a day while suffering from intense pain before. There is a limit to the amount of opioids they will prescribe you, even if you are in mind shattering pain. For instance while attempting to get your dental insurance to actually cover a treatment you may find yourself between risking organ damage or risking $5000+ in ER visit bills only to have them refuse to give you anything but Tramadol.

It is mind boggling how statements like that are possible in the US.

I guess it is much better than the situation before that, where you paid $5000+ and they also gave you an opioid addiction.

Re: Acetaminophen vs. ibuprofen

#87
post #24

If you don't make a habit of taking either, what actually performs better?

> If you don't make a habit of taking either, what actually performs better? Tylenol/acetaminophen is good for fever which NSAIDs won't help. Otherwise, take both and alternate their dosing times for better pain coverage.

"Good for fever"? Only ignorant consumers would attempt to counteract the body's very own defenses against infection and disease.

A fever is not dangerous within normal parameters, except for being dangerous to the virus and bacteria that threaten the body. Your body runs a fever because it engages in a battle to the death with these microbes.

If you defeat the body's own defenses by lowering the fever, for example if you are a nervous mother who hates her baby's fussing, or if you're hospitalized and the nurses are laser-focused on "number go down" treatments, then you can expect to be ravaged by the contagion for much longer than expected.

Re: Acetaminophen vs. ibuprofen

#88

I lived with an ICU nurse for years and one of the things he emphasized was the risk of acetaminophen overdose. He's more than once treated the liver failure (and death) from it and by his words, it's one of the worse ways to go. The positive of it is it got me in the habit of logging whenever I take it, either in a note on my phone or just a sheet of paper I place on my dresser under the bottle. This helps make sure…

I'm not disagreeing with you or trying to be disagreeable, but how do people accidentally exceed 3-4 grams daily? That's 6-8 pills!

If you take 2 on average every 4 hours, you're at 12. If you're feverish or otherwise feeling ill enough and sleep deprived enough, forgetting when you took them last is easy. Personally I write down the time I took the last one.

Re: Acetaminophen vs. ibuprofen

#89
The right tool for the right job. When it comes to medication, in the right dosage.

I'm aware of acetaminophen's down sides, and yet recently I was taking it combined with 2 other medications at the time.

Why? Because all three medications are recommended for dealing with the issue I had. (Alone and in combination)

The moment it wasn't helping further? Done.

There is this broken idea, particularly apparent in North America, but in western society that more is better for many things. It's not.

More pain killers don't do anything if they max out the relief they can give you, overloading their mechanism doesn't reduce anything, but taxing your liver or your kidneys.

All medications are potentially toxic, your body wants to dispose of them. In appropriate dosages they will benefit you, but more isn't inherently better.

Even water can kill you in sufficient quantity.

We do the same with diet; where someone declares one ingredient in a meal healthier than another; it isn't. A single ingredient isn't better or worse for you in a meal. Your diet however can be good or bad; over time that matters.

Re: Acetaminophen vs. ibuprofen

#90

You can combine the two for better effect. 1g of Paracetamol with 400mg of Ibuprofen gives similar pain relief as 2mg of IV morphine.[1] [1] https://pubmed.ncbi.nlm.nih.gov/29017585/

Plus caffeine, for those who don't drink coffee. Quite standard combo for people suffering from migraine. I stick to 500mg+200mg and I find it suspicious adverts for painkillers somehow always show 2 pills while dosage recommend in leaflet is just one.
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