> HAR1A is active in the developing human brain between the 7th and 18th gestational weeks.
Anyone know of a resource that layouts the temporal activation patterns for all the genes for the life cycle of a human being?
Human Accelerated Region 1
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Re: Human Accelerated Region 1
#42> HAR1A is active in the developing human brain between the 7th and 18th gestational weeks. Anyone know of a resource that layouts the temporal activation patterns for all the genes for the life cycle of a human being?
This can't be done reliably but you may want to look at Tabula Sapiens which doe some of what you'd like. It's not an obvious problem in lots of ways.
Re: Human Accelerated Region 1
#43> HAR1A is active in the developing human brain between the 7th and 18th gestational weeks. Anyone know of a resource that layouts the temporal activation patterns for all the genes for the life cycle of a human being?
This can't be done reliably but you may want to look at Tabula Sapiens which doe some of what you'd like. It's not an obvious problem in lots of ways.
Thanks. Suprised no one has made a visualization (even if it has gaps).
> It's not an obvious problem in lots of ways.
Care to expand on this?
Link for others:
https://www.science.org/doi/10.1126/science.abl4896
https://maayanlab.cloud/Harmonizome/dataset/Tabula+Sapiens+G...
Re: Human Accelerated Region 1
#44> HAR1A is active in the developing human brain between the 7th and 18th gestational weeks. Anyone know of a resource that layouts the temporal activation patterns for all the genes for the life cycle of a human being?
Let's assume that you mean activation patterns at the level of single cells. Aside from the ethical issues which make it virtually impossible to obtain the full set of data, there is also the fact that the exact timing of expression is one of the major ways in which development produces variability in phenotype and so can vary wildly between individuals. The closest we have right now might be HUBMAP [0] or HCA [1], but I don't think that those had as objectives covering multiple developmental timepoints.
0. https://portal.hubmapconsortium.org/ 1. https://data.humancellatlas.org/
Re: Human Accelerated Region 1
#45Interesting. So, the human brain is the scaled-up monkey brain with significant architectural changes.
Of course it is, and you could say the same with regard to mammalian brains in general. However the divergence starts very early in development (seven weeks) so is very big and very significant. By the time a human is born the brain is very different from a monkey's.
Re: Human Accelerated Region 1
#46Earlier quoted context omitted.
The most successful at communicating their view that they are the most successful. Whether they are or not. But that means they are. By that metric. Has another animal proposed they are more successful by a different metric? Crickets?
Corn, albeit not an animal has been pretty successful in terms of number of individuals. Their bi-pedal underlings have cleared swathes of land and take meticulous care of their well-being so they can bask in the sun undisturbed.
Until they are cut down and bombarded with micro waves by the very same bi-pedal underlings.
Re: Human Accelerated Region 1
#47Re: Human Accelerated Region 1
#48Interesting. So, the human brain is the scaled-up monkey brain with significant architectural changes.
Implies intelligent design I think its rather some mutations that produced more reelin and created the most successful animal in earth's history
You're positing the existence of a far more advanced lifeform than merely a clever monkey with pretensions, which then somehow created said monkeys. That's like saying that it's easy to become a millionaire, just start with a billion dollars.
That's not an explanation, you just replaced a problem with another harder one.