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Makes me want to make sure my body is donated to science as a data point to help settle this.
The trouble is that they seem extremely expensive to make and sell, so they're not terribly viable as mass-market sugar replacements, and few people are even aware they exist.
There was a tagatose-based sweetener available called "tagatesse" which was unbelievably good, but it was withdrawn from the market about a decade ago. It resurfaced some time ago, but they changed the formula and it now contains a lot of sucralose...
Anyway, to the point, there's lots of evidence to suggest that tagatose and psicose are actively healthy. They inhibit alpha-glucosidase, stimulate the release of GLP-1, boost glycogen storage in the liver, and are highly fermentable by beneficial gut bacteria. Definitely healthier than sugar.
This slop is what passes for journalism nowadays?
This topic is the perpetual motion machine of journalism: every few months I see an article about how artificial sweeteners are bad and then another article that states the opposite. Makes me want to make sure my body is donated to science as a data point to help settle this.
What a terrible article! "Sugar substitutes are a mixed sachet. They include synthetic concoctions (such as aspartame, saccharin and sucralose) and substances derived from plants, including a family of carbohydrates known as sugar alcohols (such as erythritol, maltitol, sorbitol and xylitol) and stevia." So they're all completely different substances, with completely different effects on the human body. Surely the ar…
This slop is what passes for journalism nowadays?
Then again if such an idea were so widespread, there would be no market for weight loss drugs. People would just fast to desired weight as their willpower would be ironclad.
Emphatically, no. These are industrial experiments, in a similar vein to various Canola oils but much worse. You probably heard of aspartame but there are worse things. A chemical byproduct of sucralose known as sucralose-6-acetate has been identified as highly genotoxic, meaning it breaks down DNA and may increase cancer risks. Found in common sucralose-based sweeteners, it causes a "leaky gut" by damaging intestina…
Ah, a "seed oil" guy. This is the indication to everyone what level of discourse and scientific fact you're bringing to the table.
In fact, I'll just cite one single bit in your claim-
>Contrary to their purpose, some studies show artificial sweeteners may raise type 2 diabetes risk by up to 38%
This suffers from the same "aha!" nonsense as the garbage submission (and it is garbage). The "study" you are citing was an observational, epidemiological study. And wow, crazy and hard to believe, but it turns out that people with weight problems (and all that comes with that) are more likely to have partaken of "at least one" sugar substitute drink. This is similar to studying people who chew nicotine gum and for obvious reasons finding a higher rate of lung cancer, so then declare that nicotine gum causes lung cancer. It is so staggeringly stupid it belies belief, but it makes for a headline to fool some rubes.
Tangential, are there any sweeteners which are confirmed to not affect intermittent fasting? Would love to sweeten my black coffee.
Emphatically, no. These are industrial experiments, in a similar vein to various Canola oils but much worse. You probably heard of aspartame but there are worse things. A chemical byproduct of sucralose known as sucralose-6-acetate has been identified as highly genotoxic, meaning it breaks down DNA and may increase cancer risks. Found in common sucralose-based sweeteners, it causes a "leaky gut" by damaging intestina…
>These are industrial experiments, in a similar vein to various Canola oils but much worse. Ah, a "seed oil" guy. This is the indication to everyone what level of discourse and scientific fact you're bringing to the table. In fact, I'll just cite one single bit in your claim- >Contrary to their purpose, some studies show artificial sweeteners may raise type 2 diabetes risk by up to 38% This suffers from the same "aha…
2025: https://www.sciencedirect.com/science/article/pii/S126236362...
2023: https://pmc.ncbi.nlm.nih.gov/articles/PMC10465821/
To address your point: Potential for reverse causality cannot be eliminated; however, many sensitivity analyses were computed to limit this and other potential biases
2023: Clinical review https://pmc.ncbi.nlm.nih.gov/articles/PMC10822749/
multiple studies have shown various side effects associated with the use of these sweeteners. These side effects include gastrointestinal symptoms [9], neurologic [10] and taste perception changes [11], allergic reactions [12], insulin and metabolic effects [13], and cardiovascular effects [14]. In addition, ASs have been shown to affect the gut microbiota that may mediate certain side effects [15]. Most importantly, many researchers have assessed the potential effect of ASs on the cancer risk of people who consume these products [16,17].
and
Human studies performed by Suez et al. evaluated the impact of ASs on the human microbiome. A total of 381 individuals without diabetes who self-reported regular consumption of ASs, as determined by a food frequency questionnaire, were included. The study demonstrated a significant association between the consumption of ASs and the development of central obesity, elevated fasting blood glucose levels, increased hemoglobin A1c levels, impaired glucose tolerance, and elevated alanine aminotransferase levels. In addition, a subgroup analysis was conducted to compare those who consumed higher amounts of ASs with those who did not consume any ASs. The results of this analysis revealed a statistically significant elevation in hemoglobin A1c levels, even after controlling for body mass index.