Nobody can even come up with a coherent reason for any of these proposals to exist. Even the ISS is more of a political instrument than a real science thing. NASA likes to say its about studying how to help humans live in space, but those results were in decades ago: more than a few months in zero-g wrecks people. So why are we still trying to build old modular Salyut/Mir derivatives instead of trying to figure out t…
Extended space spays doesn't really wreck people, it's just that your body adjusts to the new environment so your strength decrease, your bone density decreases, your orientation mechanisms shift to 6 degrees of freedom, and so on. Of course when you get back to Earth you're body again has to go through a readjustment phase because those previous adjustments are now unfit for the new environment, but it's nothing bey…
However, the research done on mice on ISS suggests that the undesirable effects can be mitigated by creating an artificial gravity (i.e. rotation) lower than on Earth, e.g. of 2/3 of Earth's gravity.
The failure scenarios for rotating spacecraft need not be more severe than for non-rotating spacecraft. For instance if 2 or more spacecraft, which can be also used independently, are connected with cables to enable them to rotate around the common center of mass, if everything is designed carefully the failure of the coupling system should not have any other consequences than the loss of the artificial gravity and from then on the failure risks would be the same as for non-rotating spacecraft.