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Study finds no evidence cannabis helps anxiety, depression, or PTSD

sciencedaily.com

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Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#191

Earlier quoted context omitted.

As an aside, it is a well established fact that doctors, as a whole, take the the pain of black people much less seriously than the pain of non-black people.

> it is a well established fact [Citation Needed]

In emergency departments, Black patients are prescribed opioids for acute pain at a lower rate than White patients with matched chief concerns.4

Discrepancies in prescriptions for chronic pain therapies have also been identified in Veterans Administration and Medicaid payer databases, and several retrospective cohort studies have shown persistent underprescribing of analgesics to Black patients.6,7

White medical trainees, reflecting the general population, can have false beliefs about biologic differences between Black and White patients (eg, “Black patients feel less pain”), and this racial bias leads to inaccurate pain diagnoses and treatment recommendations.8

In anesthesiology and pain medicine, use of regional anesthesia for joint replacement surgery is applied less frequently in Black patients and the underinsured.9

This also holds true in the implantation of spinal cord stimulation for the treatment of postlaminectomy syndrome.10

Among patients with occupational low back injuries, Black patients incur lower treatment costs than their White counterparts and are provided fewer health care interventions, including surgery.11

Perceived discrimination results in psychological distress, and a US population–based study has demonstrated a dose-response relationship between psychological distress and chronic pain.

from the mayo link

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#194

Earlier quoted context omitted.

It's a meta-study and came to the conclusion that there isn't reliable evidence that it alleviates symptoms of a bunch of stuff: > There were no significant effects on outcomes associated with anxiety, anorexia nervosa, psychotic disorders, post-traumatic stress disorder, and opioid use disorder. There were insufficient data to meta-analyse studies of ADHD, bipolar disorder, obsessive-compulsive disorder, and tobacco…

They have some more useful figures in the paper, but for a lot of things they're essentially saying there is not enough evidence to support using cannabis yet . The strongest claim is the lack of significant effects for anxiety, ptsd etc. but it varies a bit whether that's because the effect is too small or because it is not studied enough. For anxiety for instance the effect they list in the paper is quite big but t…

I don't think I've ever heard that cannabis was a treatment for PTSD let alone a good one.

Is this paper trying to confuse people about psilocybin?

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#195

Earlier quoted context omitted.

> it is a well established fact [Citation Needed]

In emergency departments, Black patients are prescribed opioids for acute pain at a lower rate than White patients with matched chief concerns.4 Discrepancies in prescriptions for chronic pain therapies have also been identified in Veterans Administration and Medicaid payer databases, and several retrospective cohort studies have shown persistent underprescribing of analgesics to Black patients.6,7 White medical trai…

> White medical trainees, reflecting the general population, can have false beliefs about biologic differences between Black and White patients (eg, “Black patients feel less pain”), and this racial bias leads to inaccurate pain diagnoses and treatment recommendations.8

IMO, it's a little unfair to ascribe deliberate, knowing application of racist stereotypes. That kind of rhetoric by researchers can have unintended consequences, however well-intentioned, such as with the overcorrection wrt opioids, and is often used by interest groups to change policy in directions not otherwise warranted by well-founded evidence. (It's sometimes like people using "think of the children" as a way to stream roll more nuanced, narrowly focused debate.) There is material evidence that, broadly speaking, different ethnicities have different skin characteristics, including thickness (which is admittedly often used in an imprecise manner, but can defensibly include characteristics like elasticity). It figures prominently into aging, and generally considered part of the reason why "whites" (for lack of more precise categorization) tend to wrinkle more with age, particularly relative to Asians with similar skin tone. (Contra stereotypes, some research shows Asians have "thicker" skin than whites and blacks, at least in the sense of being less prone to wrinkle for similar phenotypic pigmentation.) Papers that make the claim of prima facie racism like https://jamanetwork.com/journals/jamadermatology/article-abs... say in the abstract the beliefs are unfounded, but in the full article only go so far as to admit the evidence is equivocal or that doctors draw unnecessary or unsupported implications.[1]

Nonetheless, it's fair to say non-specialists shouldn't be making treatment decisions based on such poor and otherwise collateral evidence. And I would agree the evidence for racially disparate pain management treatment generally is very compelling, just that the racism is more implicit and unconscious. All race-based distinguishers are highly suspect, IMO, even when they accurately reflect a group in context. But unless and until medical systems comprehensively adopt personalized genetic profiling (given various limitations in cost, time, and well-researched data, something still pretty far off for general medicine), doctors are kind of stuck wrestling with old epidemiologic classifiers.

[1] The abstract says, "Although race is a social construct, the biomedical sciences—including dermatological science—have been used to promote the false idea that race has a biological basis. The study of race-based differences in skin thickness is an example." But the full-text says: "Race-based differences in skin thickness remain an active area of investigation. A review of the literature (1977-2014) reporting differences in aging skin across race and/or ethnicity noted that Asian and Black skin had 'thicker and more compact dermis' than White skin, 'with the thickness being proportional to the degree of pigmentation."4 A 2022 meta-analysis of 133 studies concluded that any difference in epidermal thickness in healthy human skin was minor, calling into question the usefulness of distinguishing skin thickness among racial groups.5" Note that this summation is putting a gloss onto research that is itself equivocal, but then is cited in policy debates to make claims about what "the science" unequivocally says.

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#196
post #143

Earlier quoted context omitted.

Shouldn't that be up to bodily autonomy? If someone feels that cocane relieves their symptoms then who is the doctor to say that they don't. Perhaps releaving those symptoms even for a short period of time is worth the consequences.

That's just arguing for drug legalization with extra pseudoscience. I am all for people doing however much cocaine they feel they need. In broad daylight - let's just drag that into the light and let people go to the dispensary for cocaine hydrochloride, metered, measured and with warning labels. Because the war on drugs is a stupid waste of time and lives, but no doctor or medical professional has to justify your ow…

It’s also an argument for quackery and snake oil, as long as the salesman declares “some people said it works!”

“People should be allowed bodily autonomy to take whatever chemicals they want” easily and dangerously turns into “People should be able to advertise and sell miracle cures that don’t work as long as their victims are gullible.”

Every snake oil fraudster hides their fraud behind principles like bodily autonomy.

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#197

The entire point of the drug research is to make them palatable to authorities through plausible lies. American culture does not permit enjoyment for the sake of it. So you have to make up some stories and say “there is some evidence that psilocybin helps depression” or whatever and then slowly leak it towards legality. I mean if I told you I wanted to have fun you’d lose your mind. But if I told you I needed to heal…

To be fair, ever since I’ve started weekly psilocybin microdoses for depression I’ve been able to stop my regular anti-depressants which had some nasty side effects. And in those 3 years, I’ve had exactly zero depressive breakdowns like I used to have.

I don’t really enjoy the feeling of a normal dose of shrooms, but with a microdose below a noticeable effect (sometimes I overshoot a little and it gets a little warm and tingly), I have in fact had a huge quality of life increase.

I guess in some ways “not wanting to die regularly” could be seen as “having fun” by some people, and I’m sure that if a proper study was done the result would be inconclusive. I mostly think that the inconclusiveness in these depression studies has much to do with a lack of understanding of what depression even is and thus a lot of them have people with very different root causes of their pathology all being labeled “depression.”

But it works for me, and it works very well. (And 2g of shrooms per month is also dirt cheap compared to expensive anti-depressants.)

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#198

Earlier quoted context omitted.

”There’s a difference between intoxication and treating the chemical imbalance behind depression or anxiety.” There is no significant, rigorous evidence that depression or anxiety are caused by an inherent ”chemical imbalance”.

Am I an idiot or is it not glaringly obvious to everyone that the cause is our individualistic hyper competitive culture?

"Patient is chronically lonely" isn't really a diagnosis, even though it should be.

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#199

Earlier quoted context omitted.

It sounds to me like you didn't understand the paper at all, or are worse willfully misrepresenting. The paper says "insufficient data" for helpfulness for most positive categories (but leans more positive than negative just doesn't reach 95% confidence), but also insufficient data on most negative categories. It finds 5 conditions it's helpful for, and 3 it hurts for.

I'm directly quoting the portion of the abstract related to anxiety and depression, tell me how that's misrepresenting? > There was an absence of RCT evidence for the treatment of depression. > Meta-analysis revealed higher odds of all-cause adverse events (OR 1·75, 95% CI 1·25 to 2·46) among those using cannabis versus control group And my point was that the paper talks about absence of data about efficacy on treatm…

The abstract is not the full study. This is why people should have training in research methods before saying they know how to understand research papers

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#200
post #66

American media has really been shockingly pro weed/cannabis for the past 20 or so years. Really astounding to witness considering the well known downsides to human health and cognitive function. Main characters smoke weed as a cool disobedience, in sitcoms even. Wonder what is behind it, from my perspective it's quite remarkable.

I think there’s probably some adjacency to other things which make people feel good, but are ultimately bad for them. Gambling, alcohol, porn, infinite scroll social media. There are a few people making a ton of money on this stuff and the social costs aren’t something they care about.

Lol pornography is not fundamentally bad for people. This remains the weirdest widespread take on HN
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