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Study finds no evidence cannabis helps anxiety, depression, or PTSD

sciencedaily.com

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Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#161

Post by fdgfikgfv »

Aurornis wrote: post #12

This is a hard topic to communicate in depression treatment. It's easy to mistake substances that temporarily boost your mood or calm your nerves for effective treatments for an underlying condition. There was a brief period of time before the opioid prescribing backlash when some fringe psychiatrists were proposing weaker opioids as adjunctive treatments for treatment resistant depression. It's hard to fathom now, b…

Sadly, I have witnessed three of my friends who started THC product to deal with anxiety, developed paranoia. Two of them quit THC and got better but one got way worse and now is in process of divorce. His personality is completely different, he was pretty chill guy but now he is talking way too much, easily distracted, and always worried about macro events.

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#162

Post by Natsu »

johnisgood wrote: post #88
Aurornis wrote: post #74

Earlier quoted context omitted.

> The point Im making is this is true for a ton of psychiatric or even non psychatric treatments That point wasn't intended to be taken in isolation. I was making statements about how long-term treatment of an underlying condition is not the same as taking a drug which temporarily masks a problem or induces altered mood states. The fact that a drug has acute effects, good or bad, is separate from any conversation abo…

You keep ignoring the fact that what you just said applies to current medications used to treat depression and anxiety. They do not treat the underlying issue long-term, and if you stop them, you are worse off than before due to rebound effects, and even if those effects subdue, your depression and anxiety returns. And just to add to this for clarification, antidepressants may treat depression, but it does not cure i…

> You keep ignoring the fact that what you just said applies to current medications used to treat depression and anxiety. They do not treat the underlying issue long-term

Those do cause improvement in self-reported feelings long term, i.e. they lower the baseline levels over a long period of time, rather than just for a short period right after you take the drug.

But you'd be right to say that they're not very good, i.e. that doesn't help your life very much. If there's an actual underlying cause, like sleep apnea, treating that will help a lot more.

Ketamine is a harder case, it really does cause improvement, but it lasts about two weeks. It also can cause psychosis, which is very dangerous. The s-ketamine the FDA approved for use in treatments is also via an inhaler, so it's both purer and via a different route than other a lot of other ketamine usage and it was approved because it actually showed a measurable effect in studies.

But it's really awful to use and if you find out that, say, sleep apnea was actually causing the issues, treating that will do a lot more good than inhaling s-ketamine ever did.

As you may have inferred, I write this based on personal experience.

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#163

Post by briHass »

andoando wrote: post #152
thesmtsolver2 wrote: post #117

Earlier quoted context omitted.

Just like how Hydrogen peroxide is chemically no different than a low dose of dihydrogen monoxide?

No not just like it, because the only difference with methampathemines is that the added meth group makes it able to cross the blood barrier much quicker, hence why I said its equivalent to a lose dose of meth. The chemical/biological response on the body and brain are very similar, the difference is in potency

But onset of action is a very important distinction in medicine/pharmacology, as is dose.

Most abusers of methamphetamine are not taking it orally (slow route of administration) and are generally using much higher relative dosing than ADHD patients are using amphetamines. Potential for addiction and other physical harms are greatly affected by both of those things, so the comparison has some truth, but is obviously sensationalized.

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#164

Post by MaxfordAndSons »

econ wrote: post #98

Not entirely on topic: If pot is illegal people will grow extremely potent variaties. If it's normal you get very tasty variaties that give a mild buzz even if you smoke pure joints all day. It's like comparing a casual light beer with the 90% moonshine or 45% bathtub gin sold during prohibition.

Idk, you can still find outrageously potent weed in states where it's recreationally legal. But maybe it's just a residual from the fact that it was illegal not that long ago and binge consuming it is still quite normalized?

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#165

Post by SecretDreams »

Aurornis wrote: post #154
SecretDreams wrote: post #109

Earlier quoted context omitted.

> anyone who understands the scientific publishing landscape. Anyone genuinely familiar with the scientific publishing process probably holds the most skepticism around publications. I could probably get ANYTHING published if I wrote it well enough. IMO, publications are mostly useful if you're already a bit of an SME in the field so that you can parse snake oil from gold. Certain publishers and institutions also hol…

> Anyone genuinely familiar with the scientific publishing process probably holds the most skepticism around publications Healthy skepticism is a good idea The silly notion that being published means it should be dismissed or that we should assume the opposite is true is not healthy though. > The above view is independent of the current article. But it's embarrassing to see people praise the heck out of publications…

> I specifically said that not everything published in a journal is true!

Yes, but the undertone of your message was towards them being generally good and useful. Which my post disagrees with. This view hardens with every new year.

The entirety of your comment just now is predicated on this one point, which is treating your words at face value, rather than their implication. To act like I didn't understand your words, let alone read them, is an insult to the both of us - notably you. Because if you believed what you had typed, you would not expect a real response from you typing it, which would make you typing it pointless in the first place.

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#166

Post by lukan »

Aurornis wrote: post #12

This is a hard topic to communicate in depression treatment. It's easy to mistake substances that temporarily boost your mood or calm your nerves for effective treatments for an underlying condition. There was a brief period of time before the opioid prescribing backlash when some fringe psychiatrists were proposing weaker opioids as adjunctive treatments for treatment resistant depression. It's hard to fathom now, b…

"This wasn't helped by the decades of claims that claimed THC was basically free of dependency problems."

But did anyone professional made these claims?

I was pretty much told since a child, no physical dependency (unlike alcohol and nicotin) but potentially strong psychological withdraw symptoms.

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#167

Post by plurinshael »

Aurornis wrote: post #36
tannedNerd wrote: post #27

Earlier quoted context omitted.

Way to completely misunderstand and try in an underhanded way to the dismiss entourage effect. It’s not smoking 10 strains in a row it’s the fact that you need CBD THC and all the terpenes to get the effects. So the current growing trend of just getting the THC number higher tends to result in plants that don’t actually give people the full spectrum of effects, beneficial or not. So the correct way to do this would b…

> It’s not smoking 10 strains in a row I never said it was. I was saying you could run 10 different studies on 10 different strains with 10 different "entourage effect" profiles and even if all of them were negative, they would be dismissed as not having precisely the right entourage effect. If there are anti-depressant compounds in cannabis plants then they can be extracted and isolated, too. > So the correct way to…

Why would you not have to try each and every combination of features known to create a different effect on the outcome?

There are what, 500 different psycho-active chemicals in cannabis? And how many different kinds of neuro-chemicals can our brains create in synapses? And how do we even begin to organize the ways that that information is transmitted to the structure (topology) of the neural systems? And their firing action logic? And the behavior of the whole organism in question?

Seems like like multiple, multi-linear variable spaces composed within each other. None of which are understandable independently of the other. None of which are perfectly mapped or traverscible landscapes. Why wouldn’t you have to try each and every possible configuration of the system in order to understand how it works?

We are not even working with a strong philosophical foundation or definition of consciousness. We must explore every possibility, leave no stone unturned.

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#168

Post by Loughla »

XorNot wrote: post #158
mjmsmith wrote: post #124

Earlier quoted context omitted.

Students in the 90s had also lived their entire lives under the counter-productive and utterly racist War on Drugs. That might have colored their attitude more than the leftist indoctrination bogeyman.

The college indoctrination boogieman exists because it is coincidentally the first time in their lives a lot of people live away from their parents fulltime. How much your opinions change once you're not in that environment can be amazing to both yourself and to the people who think they understand you because you were financially dependent on them. New ideas or diversity or whatever: living by yourself 24/7 is a hug…

[dead]

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#169

Post by dns_snek »

andoando wrote: post #153
dns_snek wrote: post #125

Earlier quoted context omitted.

That's a terrible oversimplification. Stimulant treatments for ADHD are not supposed to produce pronounced mood-enhancing effects. Stimulant treatment has been shown to be effective indefinitely in majority of people without increasing the dosage over time. These days formulations like lisdexamfetamine and extended release methylphenidate are preferred because they have all-day efficacy with typical duration of actio…

extended release are just two doses of the drug where half the beads are delayed by ~4 hours. How is that different from taking two edibles a day and claiming full day efficacy?

That's not the case for lisdex nor Concerta methylphenidate. Some generics work that way and they're generally regarded as being worse than Concerta.

The benefit is that the medication automatically produces a smooth effects profile allowing you to live your life without timing medication to perfection.

A pronounced come-up and crash is a risk factor for abuse and addiction, so smoothing or removing the peaks and valleys is important.

Re: Study finds no evidence cannabis helps anxiety, depression, or PTSD

#170

Post by Loughla »

econ wrote: post #98

Not entirely on topic: If pot is illegal people will grow extremely potent variaties. If it's normal you get very tasty variaties that give a mild buzz even if you smoke pure joints all day. It's like comparing a casual light beer with the 90% moonshine or 45% bathtub gin sold during prohibition.

I have found the exact opposite of that. Illegal weed was mild buzz and fun. Legal weed is EXTREMELY potent. They want to pack as much THC into the legal limit as they can.
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