Live data from Hacker News

Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows

medicalxpress.com

171–175 of 175 posts

Re: Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows

#171

Earlier quoted context omitted.

Versus https://en.wikipedia.org/wiki/Argument_from_authority See also: https://www.science.org/content/article/potential-fabricatio... Amateur's asserting their opinions as facts isn't great, but epistemologically it's no worse (and systemically, like less harmful) than when the experts do it.

Experts, when given the chance, have a tendency to speak with nuance and describe the degree of confidence they have in different statements. Compare this with an amateur writing with certainty about a subject that subject matter experts continue to debate after decades of work. I know which one of the two I would rather bother listening to.

You just moved the goal post.

Saying that experts are less likely to do X doesn't say anything about the relative harm of their doing so. If some rando on the streets is shouting their opinion about what causes Alzheimer's and asserting it's God's Own Truth, it's going to cause less overall harm that a carefully worded (but equally wrong) statement from an expert. (And the fact that we tend to hold experts in higher regard is the reason we should be more concerned about them stating their opinions as facts than about amateurs doing the same.)

Re: Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows

#172
post #92

Earlier quoted context omitted.

While that is true, it doesn't change the sentiment behind “We have no cure. I don’t want to know.” if knowing the diagnosis doesn't help you personally. Sure you might have a sense of responsibility for mankind but you still know you can't do anything to save yourself. With that said, lifestyle changes can slow down the onset of Alzheimer's, so knowing the diagnosis isn't totally useless.

> We have no cure. I don’t want to know. This is an incredibly short sighted, fragile-ego protecting, selfish instinct. Making plans while you are cognizant is valuable, and the sooner you know, the longer and better plans you can make. Making plans with friends and family should be done sooner than later with these kinds of things. It absolutely helps to personally to know, but people avoid emotional pain like the p…

Maybe it is, and I'm not saying that's how I think. I would prefer to know the diagnosis. But that's not necessarily how everyone, or even most people, would act. So what if this is fragile ego and selfish? Are people not allowed to be weak, selfish?

Re: Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows

#173

For a disease which (to my knowledge) can’t be slowed down or reversed, I think it’s a fair question why we would want to detect Alzheimer’s. Maybe there are other reasons, but my suspicion is that we will be able to, and an easy detection method significantly widens the pool of subjects to study later on. If it turns out that driving a Prius on Tuesdays slows down Alzheimer’s, a larger pool of subjects would allow u…

To rule out Alzheimers when you wonder whether your recent episodes of forgetfulness have an underlying medical cause.

That aside, some moderately effective drugs have recently been approved that can slow down the disease in its early stages. And even if you are no candidate for these: you can start organising the life around you while you still can. Like moving to an assisted living facility.

Re: Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows

#174

Earlier quoted context omitted.

That's a hypothesis. If we knew that for certain, it would be really big news; and we could investigate to learn why , and then we could isolate the causative factors and perhaps find other ways of deploying them… If you know something the rest of us don't, prove it: show us the evidence, show us the specific hypotheses, describe a repeatable experiment, show us the results if such an experiment has been performed. I…

You do realize they already are investigating, right? Even looking into MS and parkinson. ALZHEIMER’S DISEASE (AD) and AD DEMENTIA Umbrella review (systematic reviews of SRs): https://www.nature.com/articles/s44400-025-00048-6 Systematic review + meta-analysis (basal microbiota; AD): https://alz-journals.onlinelibrary.wiley.com/doi/abs/10.1002... https://pmc.ncbi.nlm.nih.gov/articles/PMC11672027/ Replicated case-cont…

> You do realize they already are investigating, right?

Yes. I also realise they have not reached the conclusion of this investigation. (Imagine this attitude towards a police investigation: "They're investigating Roger Rabbit, therefore he must have dunnit!")

Re: Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows

#175
post #66

Earlier quoted context omitted.

> 94.5% in itself is suspicious No it's not, that's a reported mean, presumably with the right number of significant digits. If you want to criticize the variance/stddev, do so, but you picked the wrong metric if that's what you wanted to complain about.

How about this: def has_alzheimers(patient): return False What accuracy does this have?

High accuracy, actually, but non-existent sensitivity and high bias.

What you're looking for is called "signal detection theory".

Post reply on HN