Live data from Hacker News

Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows

medicalxpress.com

151–160 of 175 posts

Re: Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows

#151
post #51

“We have no cure. I don’t want to know.” If astronomers announced that a large asteroid might strike Earth in twenty years, and that we currently had no way to deflect it, nobody would respond by saying, “Come back when you already have the rocket.” We would immediately build better telescopes to track it precisely, refine its trajectory models, and begin developing propulsion systems capable of interception. You do…

This analogy has a rather fatal flaw, which is that we already know people who've gotten Alzheimer's , and we also know for a fact people will continue to fall victim to it, at a pretty predictable rate. i.e. the detection has already happened ! Anyone who was waiting for a potential victim to appear before researching the cure already has all the reasons they need to research it. Detecting whom exactly the next vict…

In a case like this, it is possible and even substantially likely that a "Cure" represents a treatment you can apply after an early, routine blood test but before clinically significant symptoms arise, to prevent damage from becoming significant enough to represent an illness.

Late-stage Alzheimers', if not every stage, is very likely going to involve microscopic-scale physical damage to brain tissue that is functionally irreversible.

Blowing up an asteroid after you can see it in the sky with your naked eye will not save you.

-------------

It is also possible that what we call "Alzheimers" is actually biochemically five different disorders with distinct etiologies that have the same endpoint, and that it turns out we can cure two of them. Differentiating conditions for a biomedical catch-all category would be essential; "How accurate you can get the tests" is inseparable from this process of definition.

Re: Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows

#152
post #51

“We have no cure. I don’t want to know.” If astronomers announced that a large asteroid might strike Earth in twenty years, and that we currently had no way to deflect it, nobody would respond by saying, “Come back when you already have the rocket.” We would immediately build better telescopes to track it precisely, refine its trajectory models, and begin developing propulsion systems capable of interception. You do…

This analogy has a rather fatal flaw, which is that we already know people who've gotten Alzheimer's , and we also know for a fact people will continue to fall victim to it, at a pretty predictable rate. i.e. the detection has already happened ! Anyone who was waiting for a potential victim to appear before researching the cure already has all the reasons they need to research it. Detecting whom exactly the next vict…

>Detecting whom exactly the next victim is going to be isn't really going to change anything

What if you found for example all the diagnoses happened shortly after an HSV-1 infection? The more information as to what's going on the better, for research at any rate.

Re: Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows

#153

PSA to those with family affected by dementia/Alzheimer's at a relatively early age (say Left untreated for a very long time (decade+), it spreads to the brain and causes dementia among other things. Older generations with stigmas, taboos, or from lower educational backgrounds seem (to me) less likely to get tested, so it seems plausible. Source: Have recently discovered this myself with a family member from their ne…

Yeah lots of infectious things are being found to be able to cause dementia https://www.theguardian.com/lifeandstyle/2024/dec/01/the-bra...

much of the medical profession seems a bit behind the curve on recent findings.

Re: Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows

#154
post #8

For a disease which (to my knowledge) can’t be slowed down or reversed, I think it’s a fair question why we would want to detect Alzheimer’s. Maybe there are other reasons, but my suspicion is that we will be able to, and an easy detection method significantly widens the pool of subjects to study later on. If it turns out that driving a Prius on Tuesdays slows down Alzheimer’s, a larger pool of subjects would allow u…

I would personally want to know as early as possible, so I could get my affairs in order and register my wishes around end of life care and euthanasia while I am still recognised as having full mental capacity. It's also better for people around the Alzheimer's patient, as it will let them understand why someone's personality and behaviours may be changing, and possibly let them be bit more forgiving of such changes.…

> I would personally want to know as early as possible, so I could get my affairs in order and register my wishes around end of life care and euthanasia while I am still recognised as having full mental capacity.

Everyone should assume that they could lose their full mental capacity at any moment. Strokes, brain injuries, etc. can occur at any age with no warning.

My wife and I finally went through the entire estate planning process several years ago. It was comforting to know that we had a plan for a myriad of scenarios (including the incredibly depressing decision of where our assets would go if our entire family—us and our kids—was gone at the same time).

Re: Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows

#155
post #51

“We have no cure. I don’t want to know.” If astronomers announced that a large asteroid might strike Earth in twenty years, and that we currently had no way to deflect it, nobody would respond by saying, “Come back when you already have the rocket.” We would immediately build better telescopes to track it precisely, refine its trajectory models, and begin developing propulsion systems capable of interception. You do…

>”We have no cure. I don’t want to know.”

Is this a response to another comment or did I miss the quote in the article? Otherwise it’s just a straw man.

Re: Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows

#156
post #51

“We have no cure. I don’t want to know.” If astronomers announced that a large asteroid might strike Earth in twenty years, and that we currently had no way to deflect it, nobody would respond by saying, “Come back when you already have the rocket.” We would immediately build better telescopes to track it precisely, refine its trajectory models, and begin developing propulsion systems capable of interception. You do…

Your gut bacteria is the prevention and the cure.

Re: Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows

#157

Earlier quoted context omitted.

After spending years tracking through the genetics, conditions, lab work, research papers and seeing individuals years into the condition, this model is the best I have and explains everything I currently know. Why the cluster of conditions result in the same outcome, why some treatments help some folks, but not others. But that is sort of the point of science, you take all the evidence you have and create a hypothes…

You forming a personal opinion after years of interest in the subject is fine. You asserting that opinion as a fact is the problem. It is a tale as old as time. See the story behind the term. ultracrepidarian: https://en.wiktionary.org/wiki/ultracrepidarian#English

Versus https://en.wikipedia.org/wiki/Argument_from_authority

See also: https://www.science.org/content/article/potential-fabricatio...

Amateur's asserting their opinions as facts isn't great, but epistemologically it's no worse (and systemically, like less harmful) than when the experts do it.

Re: Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows

#158
post #51

“We have no cure. I don’t want to know.” If astronomers announced that a large asteroid might strike Earth in twenty years, and that we currently had no way to deflect it, nobody would respond by saying, “Come back when you already have the rocket.” We would immediately build better telescopes to track it precisely, refine its trajectory models, and begin developing propulsion systems capable of interception. You do…

Your gut bacteria is the prevention and the cure.

That's a hypothesis. If we knew that for certain, it would be really big news; and we could investigate to learn why, and then we could isolate the causative factors and perhaps find other ways of deploying them… If you know something the rest of us don't, prove it: show us the evidence, show us the specific hypotheses, describe a repeatable experiment, show us the results if such an experiment has been performed.

If you don't know something the rest of us don't, don't be so arrogant about your pet theories. Such arrogance costs lives.

Re: Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows

#159
post #51

“We have no cure. I don’t want to know.” If astronomers announced that a large asteroid might strike Earth in twenty years, and that we currently had no way to deflect it, nobody would respond by saying, “Come back when you already have the rocket.” We would immediately build better telescopes to track it precisely, refine its trajectory models, and begin developing propulsion systems capable of interception. You do…

>Refusing to improve early, probabilistic diagnosis because today’s treatments are modest confuses sequence with outcome.

While you're right from the perspective of humanity taking the steps of gathering data then tackling the disease, most developed countries have single payer healthcare systems that require some level of cost-benefit analysis to approve covering new diagnostic systems.

Alzheimer's disease progression doesn't seem to have any notable preventative indications other than 'eat well, exercise and stay mentally active', all of which are standard recommendations.

Recall that this isn't an issue deciding between funding and non-funding. It's an issue deciding between funding Alzheimer's diagnostics, new GMP agonists, new screening options for highly preventable cancers, etc. Building out a dataset is nice but unless that's surplus money redirected from other programs it's going to come at a real flesh and blood cost.

Re: Blood test boosts Alzheimer's diagnosis accuracy to 94.5%, clinical study shows

#160
post #143

Earlier quoted context omitted.

Sir this hackernews please provide sources

https://news.mit.edu/2025/study-suggests-40hz-sensory-stimul...

n=5, success rate 60%, not blinded; but it does appear that they already had reason to test the treatment, so it's not a green jellybeans situation.
Post reply on HN