This kind of thing always makes me nervous, because you end with a mix of methods where you can (supposedly) pass arbitrary user input to them and they'll safely handle it, and methods where you can't do that without introducing vulnerabilities - but it's not at all clear which is which from the names. Ideally you design that in from the state, so any dangerous functions are very clearly dangerous from the name. But…
They do link the default configuration for "safe": https://wicg.github.io/sanitizer-api/#built-in-safe-default-...
But I agree, my default approach has usually been to only use innerText if it has untrusted content:
So if their demo is this:
container.SetHTML(`Hello, {name}`);
let greetingHeader = container.CreateElement("h1");
greetingHeader.innerText = `Hello, {name}`;