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> Osteoarthritis occurs when a joint is stressed by aging, injury or obesity. The chondrocytes begin to release pro-inflammatory molecules and to break down collagen, which is the primary structural protein of cartilage. When collagen is lost, the cartilage thins and softens; the accompanying inflammation causes the joint swelling and pain that are hallmarks of the disease. Collagen synthesis in the human body can be…
Paper: https://www.science.org/doi/10.1126/science.adx6649
https://www.science.org/action/downloadSupplement?doi=10.112...
It identifies the compound used as SW033291. Searching for it on clinicaltrials.gov gives no hits.
Earlier quoted context omitted.
The joint at the base of my thumb started telling me it's 60 years old. I stopped being able to open jars easily last year and would like to get my grip strength back.
> The joint at the base of my thumb started telling me it's 60 years old This is my biggest apprehension. I've become quite a good guitarist, and I know that can't last forever. Getting my accomplishments in while I can.
5+ years ago when I was looking for another injection, my PCP said "Well, time for a hip replacement." Now, for reasons I don't understand I think he was being way premature on that (everyone I'd talked to prior to that had said I should wait as long as I can, and it'd been 2+ years since my last shot).
But I'd pretty much accepted that hip pain was just a part of my life, (especially in the morning) picking something off the floor was painful, just walking and in particular walking stairs was just a little painful.
A few weeks ago I tried some stretches I saw on Youtube shorts. Like a minute a day. It's like I've got new hips.
I've never been a very "compliant patient" when it comes to stretching, but that was mostly because I saw no benefits from it. But this one stretch was like a miracle!
Knee replacement surgeons should be worried. Both my father and FIL had their knees replaced.
Does anyone have any idea if you have arthritis what you can do to manage the symptoms? I figure there are some people here that researched it relatively well.
Everyone with it I've ever talked to said staying moving is important: "motion is lotion."
My elderly family use lots of anti-inflammatory drugs (NSAIDS) and one of them is on Prednisone.
Two of my friends with rheumatoid arthritis (only in their 30's) are on an injectable immunotherapies (DMARDs) that have been life changing for them.
Disclaimer: not a doctor, just have lots of sore friends/family and an interest in this stuff since I have a torn ACL and fear the future.