oh, what a time to be a mouse!
Anti-aging injection regrows knee cartilage and prevents arthritis
11–20 of 185 posts
Re: Anti-aging injection regrows knee cartilage and prevents arthritis
#12As I've gotten older, my knees have been the main signal letting me know. I tore my meniscus years ago. This is exciting news for people like me.
The joint at the base of my thumb started telling me it's 60 years old. I stopped being able to open jars easily last year and would like to get my grip strength back.
> The joint at the base of my thumb started telling me it's 60 years old
This is my biggest apprehension. I've become quite a good guitarist, and I know that can't last forever. Getting my accomplishments in while I can.
Re: Anti-aging injection regrows knee cartilage and prevents arthritis
#13They don't say what is injected, calling it only a "gerozyme inhibitor". Original article appears to be:
https://www.science.org/doi/10.1126/science.adx6649
Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration Mamta Singla https://orcid.org/0000-0002-6408-1167, Yu Xin Wang https://orcid.org/0000-0001-8440-9388, Elena Monti https://orcid.org/0000-0002-3767-0855, Yudhishtar Bedi https://orcid.org/0000-0002-1213-4116, [...] , and Nidhi Bhutani https://orcid.org/0000-0002-7494-5870
FTFA: "Both systemic and local inhibition of 15-PGDH with a small molecule inhibitor (PGDHi) led to regeneration of articular cartilage and reduction in OA-associated pain."
"PGDHi" is a name for both the process "15-hydroxyprostaglandin dehydrogenase inhibition" and any inhibitor.
This link(a PDF file) shows PGDHi's are powerful stuff:
https://www.biorxiv.org/content/biorxiv/early/2025/04/17/202...
"PGDHi" could be prostaglandin-E2 (dinoprostone):
https://en.wikipedia.org/wiki/Prostaglandin_E2
which was used in:
https://med.stanford.edu/news/all-news/2025/06/muscle-aging....
Re: Anti-aging injection regrows knee cartilage and prevents arthritis
#14Hold your humans: in mice!
At this rate we're going to have mice outliving humans by 2100
Re: Anti-aging injection regrows knee cartilage and prevents arthritis
#15JAK-STAT inhibitors also downregulate 15PGDH, and in humans
they are just insanely expensive in the USA because of drug patents
Re: Anti-aging injection regrows knee cartilage and prevents arthritis
#16As I've gotten older, my knees have been the main signal letting me know. I tore my meniscus years ago. This is exciting news for people like me.
The joint at the base of my thumb started telling me it's 60 years old. I stopped being able to open jars easily last year and would like to get my grip strength back.
Broke this one in a motorcycle accident and I'm really, really not looking forward to the late life implications of it.
Re: Anti-aging injection regrows knee cartilage and prevents arthritis
#17Hold your humans: in mice!
“A pill-based version of the same therapy is already being tested in clinical trials aimed at treating muscle weakness associated with aging.”
Re: Anti-aging injection regrows knee cartilage and prevents arthritis
#18Knee replacement surgeons should be worried. Both my father and FIL had their knees replaced.
Re: Anti-aging injection regrows knee cartilage and prevents arthritis
#19Re: Anti-aging injection regrows knee cartilage and prevents arthritis
#20Knee replacement surgeons should be worried. Both my father and FIL had their knees replaced.
afaik surgeons are able to perform quite a few types of surgeries, obviously the ones working on brains more advanced than ones working on knees it's probably only a few years to transition to a different type of category.