This piece argues that antimatter could be feasible for space propulsion and we could start developing it now: https://news.ycombinator.com/item?id=46073414
What's the key point regarding how we would get a bajillion times more anti-matter than we can now generate, and without expending all the energy we now expend on getting it?
Also he proposes a few ways that antimatter could be practically used for propulsion, including as a catalyst for fission which seems interesting.