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From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

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Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#71

Post by yieldcrv »

doctoboggan wrote: post #29
neom wrote: post #4

Is there any good consensus on what the deal is with this drug yet? I don't know how to think about GLP-1. In the headlines it seems like every month it's a miracle cure for something new, yet we don't really understand it? But it seems like just generally...everyone, including me, would benefit from being on it...? The whole thing makes me uneasy but I'm not exactly sure why outside of it seems weird to have one dru…

I had just assumed that all these new things this is a cure for are just down stream affects of being overweight, and losing the weight also reduces the incidence of these other issues as well.

so its a cure for the body positivity movement and all of the proponents reverted back to default understanding of health

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#72

Post by jorvi »

philipkglass wrote: post #68
jorvi wrote: post #58

Earlier quoted context omitted.

The Alzheimer """cure""" claim was already disproven by another study. Aside from that, the people who stop taking GLP, 75% gain 50-75% of their bodyweight back and lose all concomitant cardiovascular, cancer etc. risk benefits. No research out on, say, alcoholism yet, but I'd hazard a guess the results are the same. This is not a cravings loss drug but largely a cravings management drug. Which is still pretty great…

This is not a cravings loss drug but largely a cravings management drug. Which is still pretty great but it saddles healthcare funding systems with an enormous burden for the next 20 years. Semaglutide goes off-patent in 2032 in the US, and in 2026 in Canada and China: https://journals.library.columbia.edu/index.php/stlr/blog/vi... https://www.ncbi.nlm.nih.gov/books/NBK602920/table/t03/

Wait, what? I thought these were extremely new drugs, only approved for a couple of years now.

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#73

Post by mattgreenrocks »

cjbgkagh wrote: post #57
mattgreenrocks wrote: post #55

Earlier quoted context omitted.

GLP-1s seem to induce/mimic gastroparesis, which also can occur with hEDS. Has that been an issue? Also, do you have MCAS? (Also have hEDS.)

Yeah, that's one of the reasons I waited for usage data is that I was pretty sure people with hEDS would have an overly strong reaction, and that did happen in my case and appears to have happened with other with hEDS. I started at 0.025mg (1/20th the 0.5mg starting dose at the time) and still got temporary gastroparesis which was indeed very uncomfortable. I had done long term fasting prior to semaglutide so I had t…

Wow. Glad it panned out for you.

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#74

Post by didibus »

neom wrote: post #4

Is there any good consensus on what the deal is with this drug yet? I don't know how to think about GLP-1. In the headlines it seems like every month it's a miracle cure for something new, yet we don't really understand it? But it seems like just generally...everyone, including me, would benefit from being on it...? The whole thing makes me uneasy but I'm not exactly sure why outside of it seems weird to have one dru…

It's too soon to really know the downsides. Statins for example only recently are better understood and there's a lot more downsides we know about now.

It's likely going to be true for GLP-1 as well.

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#75

Post by hammock »

neom wrote: post #4

Is there any good consensus on what the deal is with this drug yet? I don't know how to think about GLP-1. In the headlines it seems like every month it's a miracle cure for something new, yet we don't really understand it? But it seems like just generally...everyone, including me, would benefit from being on it...? The whole thing makes me uneasy but I'm not exactly sure why outside of it seems weird to have one dru…

Anything dealing with the signaling systems of the body (GLP-1 agonists, DP-XX binders like Keytruda, IL-XX binders like Humira, etc and even HRT) all fall under this bucket. We have a great understanding of some effects of some signaling systems and we use that understanding to our advantage. But the fact is these signaling molecules and receptors do a lot, more than we know, and in overlapping and complex ways, that we are always finding “new indications” and “new side effects” with roughly equal frequency.

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#77

Post by totallykvothe »

Night_Thastus wrote: post #51

Oh man, I'd love for a reduction in that. I sort-of deal with it. As a kid I had nearly daily migraines - go into a very dark quiet room and be happy when I fell asleep, since I knew the migraine wouldn't be there when I woke up. These days it's just headaches, 99% sure it's muscle tension in my neck. Kinda doubt GLP-1 could do anything for that, but I'd be pleasantly surprised....

I had very similar issues, both as a kid and an adult. I now take 500mg of Magnesium (Malate or Glycinate. NOT Citrate, as that is a laxative) nearly every night, and my headaches are almost completely gone now. I still get one every once in a while, but it's infrequent enough that I no longer worry about my use of Ibuprofen to manage it.

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#78

Post by apple4ever »

borski wrote: post #15
mikhailt wrote: post #11

Earlier quoted context omitted.

Nobody understands why it all helps, they just noticed it does work for something, quickly pushed it to the market first to get patents and get all the profits from it before generics + derivatives hit their pockets. Now, everyone is studying it because there's all new funding coming in for it and finding other versions of it that they can profit off it. Nobody knows what migraine really is, so this isn't a surprise…

> Keep in mind that a lot of the benefits go away once patients come off GLP-1 and we have not seen any studies yet on what happens to people who come off it for long term effects. Not if they increase muscle mass and change their lifestyle, like every physician (and the FDA/pharma companies) recommend. > It may in fact make things even worse and for a lot of people, they may have to stay on it for the rest of their…

> You know what’s worse than taking a GLP-1 forever? Obesity or metabolic syndrome killing you before you get to “forever.”

Bingo. Being obese has so many downstream effects. Anything that helps that is tremendous.

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#79

Post by apple4ever »

jorvi wrote: post #58
neom wrote: post #4

Is there any good consensus on what the deal is with this drug yet? I don't know how to think about GLP-1. In the headlines it seems like every month it's a miracle cure for something new, yet we don't really understand it? But it seems like just generally...everyone, including me, would benefit from being on it...? The whole thing makes me uneasy but I'm not exactly sure why outside of it seems weird to have one dru…

The Alzheimer """cure""" claim was already disproven by another study. Aside from that, the people who stop taking GLP, 75% gain 50-75% of their bodyweight back and lose all concomitant cardiovascular, cancer etc. risk benefits. No research out on, say, alcoholism yet, but I'd hazard a guess the results are the same. This is not a cravings loss drug but largely a cravings management drug. Which is still pretty great…

> the people who stop taking GLP, 75% gain 50-75% of their bodyweight back and lose all concomitant cardiovascular, cancer etc. risk benefits.

I don't think that framing is right, from another study:

* 17.5% maintained 75+% of their weight loss

* 25% maintained 50-75% of their weight loss

* 23% maintained 25-50% of their weight loss

* 24% maintained 0-25% of their weight loss

At least 75% (possibly more!) maintained some form of weight loss 25% to 75%+. That is tremendous. And 43% maintained 50%+! For reducing being overweight, that is just amazing.

> I hate that our solution to obesity is not the way Iceland treated it's youth drinking problem: reduce access to the harmful thing, give people money and support to do the healthy thing. Stick with it instead of cancelling the program if it doesn't show results in 4 years.

I don't think it's possible to "reduce access to the harmful thing" when that thing is "food".

Many people show long term results even stopping it. I don't understand this desire to say "people should suffer!" instead of taking something that helped them.

Plenty of people have tried (me included) but if it was easy to lose weight, nobody would be long term overweight.

Re: From blood sugar to brain relief: GLP-1 therapy slashes migraine frequency

#80

Post by apple4ever »

didibus wrote: post #74
neom wrote: post #4

Is there any good consensus on what the deal is with this drug yet? I don't know how to think about GLP-1. In the headlines it seems like every month it's a miracle cure for something new, yet we don't really understand it? But it seems like just generally...everyone, including me, would benefit from being on it...? The whole thing makes me uneasy but I'm not exactly sure why outside of it seems weird to have one dru…

It's too soon to really know the downsides. Statins for example only recently are better understood and there's a lot more downsides we know about now. It's likely going to be true for GLP-1 as well.

I don't know if it will. These drugs have been on the market for decades.
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