There may not be a safe off-ramp for some taking GLP-1 drugs, study suggests
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Re: There may not be a safe off-ramp for some taking GLP-1 drugs, study suggests
#2"Generally, the more weight people regained, the more their cardiovascular and metabolic health improvements reversed."
You don't say ;-) I lost 50 lbs and have kept it off for the past year while maintaining great BP. But I'm under no illusions GLP-1 medications don't have dangers and cause problems for many. It should be handled on an individual basis like any serious medication.
That said, is someone losing a lot of weight then gaining half of it back worse than them just staying where they were? I don't know the answer to that one.
Re: There may not be a safe off-ramp for some taking GLP-1 drugs, study suggests
#3There doesn’t need to be an off-ramp they just have to take it for life. Why would someone think they would keep the weight off? If they could they would have before Ozempic.
Re: There may not be a safe off-ramp for some taking GLP-1 drugs, study suggests
#4Interesting. Saying, "there may not be a safe off-ramp," doesn’t feel quite right. The article describes people losing weight while on the drugs and then regaining weight after stopping them. That's not ideal, but it does imply an off-ramp, just with regressions.
Compare that to something with no real off-ramp: testosterone replacement therapy. Once you're on TRT, you can permanently suppress your body's own testosterone production, and many men won't produce enough on their own afterward.
Re: There may not be a safe off-ramp for some taking GLP-1 drugs, study suggests
#5There doesn’t need to be an off-ramp they just have to take it for life. Why would someone think they would keep the weight off? If they could they would have before Ozempic.
> take it for life
That's literally the implication of these findings.
But one can always hope for a miracle drug that you can take for a bit, then stop, and have its effects last. Now we know that Ozempic is not that drug.
Re: There may not be a safe off-ramp for some taking GLP-1 drugs, study suggests
#6> regained significant amounts of the weight they had lost on the drug [...] blood pressure went back up, as did their cholesterol, hemoglobin A1c [...] fasting insulin
These symptoms will be familiar for anyone who has lost weight dieting and then returned to eating junk food.
Re: There may not be a safe off-ramp for some taking GLP-1 drugs, study suggests
#7The headline doesn't seem to match the article? 20% of participants did keep the weight off and 40% kept half the weight off after stopping.
So there appears to be an off-ramp, we just don't know what it is.
Re: There may not be a safe off-ramp for some taking GLP-1 drugs, study suggests
#8There doesn’t need to be an off-ramp they just have to take it for life. Why would someone think they would keep the weight off? If they could they would have before Ozempic.
I imagine the idea for some is "if I can just get myself healthier, I can then stay motivated to maintain the healthier lifestyle required to stay skinny without the drugs"
Re: There may not be a safe off-ramp for some taking GLP-1 drugs, study suggests
#9There doesn’t need to be an off-ramp they just have to take it for life. Why would someone think they would keep the weight off? If they could they would have before Ozempic.
> Why would someone think they would keep the weight off? If they could they would have before Ozempic.
I think the intuition many people have--which I am not at all defending as correct, but it certainly isn't so obviously wrong that we should scoff at someone for thinking it works this way--is more like "if my weight was stable before I did this intervention, I just need to lose the weight and then my weight will once again be stable after it"; in this mental model, one would assume you only need lots of willpower to lose weight: after, you only will need as much willpower as you already know you have to not gain it back, as it isn't as if you are gaining weight currently.
Re: There may not be a safe off-ramp for some taking GLP-1 drugs, study suggests
#10Or an alternative title: "36 months of tirzepatide permanently treated obesity in 17.5% of patients."
I think that it is quite unsurprising that without the drug a large amount of people revert to their previous behavior and with that will revert to their previous weight.