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GLP-1 drugs linked to lower death rates in colon cancer patients

today.ucsd.edu

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Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#71

Post by zemvpferreira »

richwater wrote: post #67
surfsvammel wrote: post #59

I am on GLP-1 (very low dose), and I’ve found that it seems to help me moderate my alcohol consumption as well. Maybe some thing like that could also be contributing to the effect.

Is there evidence for addiction tendencies in general? Or is it something specific to alcohol?

I’m about to go to the cinema so I can’t find you references, but there’s a lot of anecdotal evidence at least of glp1’s curbing all sorts of addictive behaviour. I personally started Mounjaro last week and my coffee cravings have gone way, way down for the first time in my adult life.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#72

Post by zemvpferreira »

JumpCrisscross wrote: post #48
bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

> I'm waiting for the other shoe to drop when it comes to GLP-1s We know there are downsides. They’re just irrelevant compared to being obese. (Or alcoholic. Or, potentially, overweight.) It might be a vitamin, where there literally aren’t any downsides. I’m sceptical of that. But to the degree there is mass cognitive bias in respect of GLP-1s, it’s against them. (I suspect these are sour grapes due to the drugs bein…

GLP-1’s should make you less concerned in that case, they’re poised to become extremely affordable very soon. Ending the obesity epidemic will do more to bridge the class divide than anything I can practically imagine. Not to mention the other compulsions these drugs help moderate - alcohol, tobacco, gambling etc. It’s my best hope for worldwide quality of life improvement in the next 10 years.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#73

Post by AndrewDucker »

ilikecakeandpie wrote: post #54
gwbas1c wrote: post #7

Earlier quoted context omitted.

Some people stop using it due to personality changes.

Yeah I stopped because I didn't like the way it made me feel. I needed it because my blood sugar was way too high and it helped me drop close to 60 pounds in 6-8 months, but I did not like how it made me feel and I lost more muscle than I was happy with. I've gained about 15-20 pounds back, but I'm now much healthier overall. I like how my brain works and I didn't like something affecting or changing that because I c…

I'd be interested to know how it changed you.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#74

Post by kube-system »

k_roy wrote: post #66
exabrial wrote: post #21

Earlier quoted context omitted.

Private people invested a lot of money to develop this and get it through testing. Allowing them to reap the benefits from their investment for a limited time is just fine. It's not people couldn't also: Diet, exercise, choose veggies, eat more fiber, etc

Protecting it before generic is fine, but the pricing doesn't make sense. If it's $1000 per month cost per person when it's the name brand, how many people are on it? At this point just the diabetics and people with really good insurance? Wouldn't they make a hell of a lot more money selling it for $100 during their protected period to 1000x the people.

They have direct discount programs where they sell at ~ half price.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#76

Post by andy_ppp »

pedalpete wrote: post #65
andy_ppp wrote: post #56

If you eat less your stomach/whole body gets time to relax and repair?

My understanding is that it slows the digestive process, so there isn't more "empty time to repair or relax". But my thinking there may be naive.

I just know someone who skips breakfast and lunch on the jabs… maybe he eats dinner I’ve not checked.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#77

Post by SoftTalker »

richwater wrote: post #67
surfsvammel wrote: post #59

I am on GLP-1 (very low dose), and I’ve found that it seems to help me moderate my alcohol consumption as well. Maybe some thing like that could also be contributing to the effect.

Is there evidence for addiction tendencies in general? Or is it something specific to alcohol?

I believe there is, I don't recall the source but have read that these drugs work by reducing cravings. So they have shown at least hints that they can work on any addictive behavior, not just overeating.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#78

Post by 45764986 »

bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

These drugs have been around for more than 10 years. If there were significant downsides, we probably would have seen them already.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#79

Post by bossyTeacher »

bicx wrote: post #2

Maybe I'm just an aging cynic, but I'm waiting for the other shoe to drop when it comes to GLP-1s. There have been so many claims of positive benefits that it almost seems too good to be true. With them being so expensive, the producers have every incentive to upsell using any study they can get their hands or money on. If it's all upside, then I'm happy to be wrong.

Given all the potential money, if they are issues, I expect it to go down like tobacco companies back in the days actively suppressing undesirable research by harassing researchers, influencing peer review journals or/and funding research casting doubt on the benefits of this drug. Chances are that any negative effects won't be obvious until it's too late. Look at microplastics, they have been around for just over a century and it's only now that we are starting to realize that they have several negative effects.

Re: GLP-1 drugs linked to lower death rates in colon cancer patients

#80

Post by exabrial »

cess11 wrote: post #64
exabrial wrote: post #21

Earlier quoted context omitted.

Private people invested a lot of money to develop this and get it through testing. Allowing them to reap the benefits from their investment for a limited time is just fine. It's not people couldn't also: Diet, exercise, choose veggies, eat more fiber, etc

Kind of weird to assume other people think it's fine to exchange human lives for money. Is it ethical for me to pay someone to murder you? Does it matter if it costs me a large amount of money or not?

This is a great example of a straw-man attack.
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