Choosing us-east-1 as your primary region is good, because when you're down, everybody's down, too. You don't get this luxury with other US regions!
Is us-east-1 equally unstable to the other regions? My impression was that Amazon deployed changes to us-east-1 first so it's the most unstable region.
But there are some people on Reddit who think we are all wrong but won't say anything more. So... whatever.
Nothing in the outage history really stands out as "this is the first time we tried this and oops" except for us-east-1.
It's always possible for things to succeed at a smaller scale and fail at full scale, but again none of them really stand out as that to me. Or at least, not any in the last ten years. I'm allowing that anything older than that is on the far side of substantial process changes and isn't representative anymore.