I enjoyed the talk, and I agree with some of what he says. My real problem with the talk is that isn't testable - it makes an observation, then goes back into the facts to justify it. I'm not seeing enough of the hypothesis-testing approach that is the cornerstone of real science.
I don't want to seem like I'm being too hard on the guy. After all, some questions just can't be approached this way. We can measure the effectiveness of a new drug on blood pressure through hypothesis and testing, but it would be very difficult, maybe impossible, to use this approach to determine why the first world war was fought. Sometimes you just have to go back through the facts and construct a plausable case. But it isn't science anymore.
Aside from that, I agree (for what it's worth) with much of what he has to say, but I still think he has understated the degree of exclusion women have experienced from male networks. It's really damaging.
Suppose that it's true, as the author stated, that men are more likely than women to be wired for risk. Sounds reasonable enough. But that might still mean that for every 5 people with the ability and inclination do do something risky (say, found a startup), 4 are male and one is female. But the way males form networks often excludes the women - even in the modern day. I don't think it's on purpose, and there's rarely any malice, but it's just as damaging.
You generally pick friends for your startup. The people you get drunk with, stay up all night completing the compiler class with, cram into a hotel room in vegas with... and you tend to do these things with close friends who are almost always other guys. If 4/5 are guys, then the odds that a man will find like-minded buddies is much higher than it is for women.
I double majored in Math and English. It was a trip. I'd count the ratio of men to women in each class, and it was usuall between 5:1 and 10:1. And in the math class (sorry to say it), many of the women were planning on becoming math teachers.
This means that the women with the ability and inclination to do startups have to break into the boys club or they'll be left in the cold. So far, they're usually left in the cold. If this weren't the case, I have no doubt we'd see far more women in fields that require a high degree of risk, creativity, and collaboration.