71–80 of 95 posts
No legal slop, just email address of runpod/prime-intelect/x-gpu provider account and deposit directly $5000 there. let them waste it.
You can easily filter who's worth receiving by they github and huggingface history.
Here is the original study published in nature microbiology. https://www.nature.com/articles/s41564-025-02142-0 Wanted to share what I thought the interesting parts. From the university press release. "To date, AI has been leveraged as a tool for predicting which molecules might have therapeutic potential, but this study used it to describe what researchers call “mechanism of action” (MOA) — or how drugs attack disea…
What???? We knew that LolCDE was a vulnerability to e coli since well before 2016 and knew inhibitors of the complex, globomycin being one of them, which they knew about since 1978 https://journals.asm.org/doi/full/10.1128/jb.00502-16 https://pubmed.ncbi.nlm.nih.gov/353012/ Is enterololin just another from of globomycin? Is AI smart or are scientists just getting dumber?
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That's only if there are experts there. The average college is not really what you're thinking it is.
The Reverse Gell-Mann Amnesia Effect-- one vastly underestimates the work it took to reach a conclusion in a book they haven't finished reading. Then, without reading another page, they assume everything in the entire bookshelf is at the same shallow level as their own misapprehension of the book they didn't finish. I rankly speculate: for the set of low-effort comments on HN, there are more Reverse Gell-Manns than t…
Here is the original study published in nature microbiology. https://www.nature.com/articles/s41564-025-02142-0 Wanted to share what I thought the interesting parts. From the university press release. "To date, AI has been leveraged as a tool for predicting which molecules might have therapeutic potential, but this study used it to describe what researchers call “mechanism of action” (MOA) — or how drugs attack disea…
What???? We knew that LolCDE was a vulnerability to e coli since well before 2016 and knew inhibitors of the complex, globomycin being one of them, which they knew about since 1978 https://journals.asm.org/doi/full/10.1128/jb.00502-16 https://pubmed.ncbi.nlm.nih.gov/353012/ Is enterololin just another from of globomycin? Is AI smart or are scientists just getting dumber?
To be clear, what the researchers & AI here have discovered is not a treatment for IBD per se. Rather, the gut of some people, especially people with IBD and people who have received broad spectrum antibiotics, can be colonized by enterobacter species. These are bacteria (including some kinds of E. Coli) that are resistant to broad spectrum antibiotics, and this overgrowth is not good for gut health. The researchers…
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Sounds like you first decimated the bacteria with antibiotics, and then made it heavily disadvantaged by eating something that preferentially feeds other gut bacteria. What was the food, out of curiosity?
Actually when I medicated it, it was with mesalamine, not an antibiotic. I didn't do anything to attack the bacteria. The meal consisted of well-boiled meat (pork/beef/chicken together, slow cooked, overnight), and carrots, zucchini, and butternut squash cooked in its juice until it mostly wasn't soup anymore.
To be clear, what the researchers & AI here have discovered is not a treatment for IBD per se. Rather, the gut of some people, especially people with IBD and people who have received broad spectrum antibiotics, can be colonized by enterobacter species. These are bacteria (including some kinds of E. Coli) that are resistant to broad spectrum antibiotics, and this overgrowth is not good for gut health. The researchers…
It’s long been theorized (not proven) that fully balancing the microbiome in IBD patients might interrupt the disease cycle and lead to remission.
https://www.gastroenterologyadvisor.com/news/escherichia-col...
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We don't know. It's probably a combo of genetic factors and bacteria. It's at the very least complicated and multifaceted, because you can't just take a culture or biopsy of inflamed skin and say "A ha! This is clearly different!" All the most effective treatments try to turn off parts of the immune system, and even though have minor success with some patients going through multiple different immunosuppressants to fi…
It's also the case that there is a bewildering variety of things that get sort of lumped together as "IBD." Crohn's and ulcerative colitis are two of them, but there's no particular reason to assume inflammatory bowel diseases all have the same set of causes. Pretty much all of them are made worse by an e. coli infection, though, so a drug that can target just those bacteria is helpful! During my own IBD journey, I'v…
I am a FUT2 non-secretor who suffered with IBS-D for years. I had to cure myself as well. Very strict diet and high seaweed (it contains fucose (not fructose)). Not one doctor cares. I tell you, it is a mental disorder.
Earlier quoted context omitted.
Actually when I medicated it, it was with mesalamine, not an antibiotic. I didn't do anything to attack the bacteria. The meal consisted of well-boiled meat (pork/beef/chicken together, slow cooked, overnight), and carrots, zucchini, and butternut squash cooked in its juice until it mostly wasn't soup anymore.
It's possible it still had some antibiotic properties, lots of commonly used drugs interact with our gut bacteria in varying ways. And indeed a quick search suggests that this might be the case: https://pmc.ncbi.nlm.nih.gov/articles/PMC5514548/