61–70 of 80 posts
Exposure to radiation up-regulates genes involved in DNA repair pathways, genes associated with antioxidant defense (notably those downstream of the Nrf2 transcription factor) and autophagy-related genes (which are crucial for the degradation and recycling of cellular components). Fasting does all those things, too -- without introducing random errors into one's DNA. Basically everyone under 40 should do regular fast…
This might be one of those cures that works like the old T-Gel shampoo (ie: carcinogenic coal tar that turned out to be immune-suppressing enough to prevent dandruff eventually caused cancer). Though, at the ages when Osteoarthritis shows up, it might be better to take on a smaller risk of monitor-able extremity cancer than the pretty large QoL reduction of severe arthritis.
Wow! I've actually used T-Gel because I used to get dandruff really bad as a teen and it was pretty effective. It's horrifying to know what it really was.
Earlier quoted context omitted.
There is a theory (theory! very theoretical) that the risk from radiation does not scale linearly and that low doses of radiation might actually be protective. See https://en.m.wikipedia.org/wiki/Radiation_hormesis
The residential radon mitigation industry does not like this.
In no way is UV caused DNA damage good for a person in any dose. The effectiveness of this treatment has nothing to do with vitamin D generation or hormonal changes as far as I know. You have to damage your skin to somehow reset the immune system and get the result. It is a bargain with the devil as I think are many radiation based therapies. That doesn't mean they aren't useful.
I'd much more prefer allogeneic stem cell treatment for osteoarthitis. It's a shame it's not available in all those countries where millions of dollars are made by companies making knee joint replacement prosthesis. What a coincidence.
https://physicians.dukehealth.org/articles/stem-cell-therapy... Which countries is it a available/approved in?
Earlier quoted context omitted.
There is a theory (theory! very theoretical) that the risk from radiation does not scale linearly and that low doses of radiation might actually be protective. See https://en.m.wikipedia.org/wiki/Radiation_hormesis
There is the alternative observation that sometimes the effect of harmful things is based on the frequency and length of exposure, not so much its magnitude. Compare with the CTE, where a few bone-crushing traumas do not seem to cause it, but chronic long-term low grade impacts is more likely to cause it. Another example, I probably could eat a massive amount of processed meat a few times without much ill effect, but…
This might be one of those cures that works like the old T-Gel shampoo (ie: carcinogenic coal tar that turned out to be immune-suppressing enough to prevent dandruff eventually caused cancer). Though, at the ages when Osteoarthritis shows up, it might be better to take on a smaller risk of monitor-able extremity cancer than the pretty large QoL reduction of severe arthritis.
Coal tar is technically carcinogenic, yes, but no study has found any association with cancer when used topically in low doses [1].
Coal tar's mechanism of action is thought to be carbazole, an aryl hydrocarbon. It is assumed to work through binding to the aryl hydrocarbon receptor, a relatively newly discovered immune cell regulator. Tapinarof (Vtama) is a new medication that also works on ArH and is really effective at reducing inflammation.
Coal tar was also used together with UVA light and psoralen (a light-sensitizing medication) to treat skin diseases like psoriasis, a protocol called Goeckerman therapy that's no longer commonly practiced. This combination does carry the risk of cancer, but it's probably due to the UVA and not the coal tar.
[1] https://www.sciencedirect.com/science/article/pii/S0022202X1...
This might be one of those cures that works like the old T-Gel shampoo (ie: carcinogenic coal tar that turned out to be immune-suppressing enough to prevent dandruff eventually caused cancer). Though, at the ages when Osteoarthritis shows up, it might be better to take on a smaller risk of monitor-able extremity cancer than the pretty large QoL reduction of severe arthritis.
Wow! I've actually used T-Gel because I used to get dandruff really bad as a teen and it was pretty effective. It's horrifying to know what it really was.
Glad to see this! We need better treatments for OA short of a joint replacement. I'm not too surprised that this treatment works. It's essentially like localized steroids to just the joint- killing off the immune cells causing inflammation. Good features is that it's localized (so no systemic immunosuppression) and the risk of cancer is low since you rarely get radiation-induced cancer in joints because there's not e…
> It's essentially like localized steroids to just the joint- killing off the immune cells causing inflammation. Are you confusing osteoarthritis with rheumatoid arthritis? I didn't think the pain of osteoarthritis had anything to do with the immune response. You've literally got bone rubbing against bone. It's not going to feel good.