Earlier quoted context omitted.
Can you say where the scariest and most ambitious convincing pitch was on the following scale? 1) We're going to build the next Facebook! 2) We're going to found the next Apple! 3) Our product will create sweeping political change! This will produce a major economic revolution in at least one country! (Seasteading would be change on this level if it worked; creating a new country successfully is around the same level…
I don't think this scale applies so well in the healthcare vertical. Any major healthcare breakthrough is going to hit the latter half of 6 at least a bit, but I'm not sure that those all induce changes that scale above 5.
For that, you'd have to think seriously big - doubling our expected lifespan is important, but it wouldn't bring that much of a change in our planet. A significantly improved homo sapiens species may qualify. Or a way to keep us going on forever - permanently fixing or replacing our bodies. Or a way to "upload" skills to brains, matrix-style.
6 is not making the current condition slightly more bearable - it's transferring us to a radically different state.