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Review of Anti-Aging Drugs

scienceblog.com

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Re: Review of Anti-Aging Drugs

#21

Post by rscho »

cactusplant7374 wrote: post #14
YZF wrote: post #9

Earlier quoted context omitted.

The dosage for longevity is supposed to be low enough that this risk is minimized. Lots of things you do modulate your immune system (including e.g. exercise). It's a risk/reward thing, every time you get into your car you're also taking a longevity risk. I think there are some proper human trials happening but the jury is still out.

> I think there are some proper human trials happening but the jury is still out. That's exactly my point. No one really knows the risk that they are taking.

Surprisingly, many people seem to think that pushing a few random pills into a machine optimized over some million years of evolution will tune it so it works better. Go figure...

Re: Review of Anti-Aging Drugs

#22

Post by andoando »

pama wrote: post #15

Be careful when reading such blogs: > Note that the dosage in the mouse experiments is quite high — 0.1% of the body weight every day, meaning about 2 ounces a day for me (70 kg). Mouse and human metabolism are very different. A better starting estimate would be 5g/day, not 57g/day. I hope people dont accidentally overdose themselves because of lack of a pharmacology background.

I just learned this the other day, but its called allometric scaling. Definitely far off linear.

Re: Review of Anti-Aging Drugs

#23

Post by bluGill »

catigula wrote: post #19

A lot of people in the comments are talking about the "problem" of death and approaches to take, but really, the only thing you can do is philosophically make your peace. Anything else at this point is yelling into infinity.

Realistically you can maybe get another couple year from what I can tell. Is it worth it?

I'd focus more on qulalitiy of your life. not everyone will die of something all these can help with, the obese person I used to know enjoyed eating - and we can now say in hindsight that diet changes would not have helped him live longer.

Re: Review of Anti-Aging Drugs

#24

Post by cm2012 »

cj wrote: post #2

From the conclusion paragraph: > Your primary life extension program is diet and exercise. Choose a diet that works for you. Stay slim. Considering heart disease is the #1 killer, doing whatever you can to not die from heart disease is the best place for most people to start. Even in 2025, diet and exercise are still king.

Your overall mortality is actually best when you are overweight but not obese.

Life expectancy at overweight bmi > standard bmi > obese bmi > underweight bmi.

A few extra pounds when you are older helps you survive illness.

The data is really really clear and replicated on this.

Re: Review of Anti-Aging Drugs

#26

Post by Etheryte »

rscho wrote: post #21
cactusplant7374 wrote: post #14

Earlier quoted context omitted.

> I think there are some proper human trials happening but the jury is still out. That's exactly my point. No one really knows the risk that they are taking.

Surprisingly, many people seem to think that pushing a few random pills into a machine optimized over some million years of evolution will tune it so it works better. Go figure...

It works for the majority of modern medicine, so it's not all that black and white.

Re: Review of Anti-Aging Drugs

#28

Post by untrust »

cj wrote: post #2

From the conclusion paragraph: > Your primary life extension program is diet and exercise. Choose a diet that works for you. Stay slim. Considering heart disease is the #1 killer, doing whatever you can to not die from heart disease is the best place for most people to start. Even in 2025, diet and exercise are still king.

And sleep

Re: Review of Anti-Aging Drugs

#30

Post by lokrian »

cactusplant7374 wrote: post #14
YZF wrote: post #9

Earlier quoted context omitted.

The dosage for longevity is supposed to be low enough that this risk is minimized. Lots of things you do modulate your immune system (including e.g. exercise). It's a risk/reward thing, every time you get into your car you're also taking a longevity risk. I think there are some proper human trials happening but the jury is still out.

> I think there are some proper human trials happening but the jury is still out. That's exactly my point. No one really knows the risk that they are taking.

People are still getting nerve damage from too much vitamin B6 in energy drinks and vitamin supplements, and that's a well known and widely taken vitamin. The idea that you can take experimental drugs your entire life at little risk is optimistic.
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