I doubt the human psyche is capable of such a voyage while being awake the whole time. Even with all the toys and biomes, life will get boring and pointless fast, producing unfulfilled needs, disorder, conflict and revolt. People can't be ants in a colony working for such a narrowly defined goal through a lifetime, especially not multi-generationally. Our existence is based on constant questioning and revolutions. A…
I suspect it’ll be easier to adapt the human species to be compatible with long-duration travel than to design spaceships to accommodate humans as-is.
Like do you really care how long it takes to get somewhere if it subjectively happens in the blink of an eye? Would you even necessarily be likely to lose your own peer group if you all spent significant time in hibernation travel between meetings?