I wonder is this why creatine gives me more energy?
Sleep all comes down to the mitochondria
191–200 of 325 posts
Re: Sleep all comes down to the mitochondria
#192the powerhouse of the cell
Re: Sleep all comes down to the mitochondria
#193Earlier quoted context omitted.
Plants breathe out oxygen, like we breathe out the other one.
That's true for photosynthesis but don't they still have oxygen respiration (i.e. oxidizing sugar for energy?)
They need oxygen for the mitochondrial electron transport chain to produce ATP. The vast majority of multicellular organisms need oxygen for that reason, and I can count the exceptions on one or two hands (i.e. Pogonophoran tube worms, some anaerobic sponges, a few parasitic helminths).
Re: Sleep all comes down to the mitochondria
#194Earlier quoted context omitted.
Workaholism is always just manifesting underlying psychical issues, be it some form of OCD, deep unhappiness with one's life and escapism from emptiness or similar. Such state manifests in many destructive behaviors, which then like in case of sleep create their own forces of destruction. One can't escape psychology, one thing no school taught me (and they should have since we all deal with this in some way! plus its…
Maybe some people just enjoy working.
Being addicted to workahol means they aren't able to enjoy other things. Your comment is like saying "maybe alcoholics just enjoy drinking".
Re: Sleep all comes down to the mitochondria
#195So the ancient mystery of why we need sleep might have just been answered. The paper shows that cell‑autonomous mild uncoupling in Drosophila sleep‑inducing neurons -- via Ucp4A/Ucp4C -- keeps the flies awake by lowering mitochondrial Δp and therefore electron leak. This suggests a biochemical rationale for sleep -- which is postponed by the uncoupler. That form of pharmacological manipulation is also a very local in…
Does it explain why we need sleep? My read was it explains why we get sleepy.
Iirc it is adenosine build up that makes us sleepy
Re: Sleep all comes down to the mitochondria
#196So the ancient mystery of why we need sleep might have just been answered. The paper shows that cell‑autonomous mild uncoupling in Drosophila sleep‑inducing neurons -- via Ucp4A/Ucp4C -- keeps the flies awake by lowering mitochondrial Δp and therefore electron leak. This suggests a biochemical rationale for sleep -- which is postponed by the uncoupler. That form of pharmacological manipulation is also a very local in…
> So the ancient mystery of why we need sleep might have just been answered.
No, science doesn't work that way. The ancient mystery of why we need sleep has a new theory [1].
[1] I am assuming it is new. It might actually be old. I don't know.
Re: Sleep all comes down to the mitochondria
#197Earlier quoted context omitted.
That's a bizarre coincidence. For the past few days I've run across a bunch of accounts of people taking more creatine than suggested (10-20g a day). They seem to all talk about how it makes them work better during sleep deprivation. So the answer seems like it helps.
Do you have any links? This is interesting
I’ve seen some social media posts in the last week by Rhonda Patrick discussing 20g/day for cognitive benefits.
Can’t find that post, but here is a breakdown of claims from an interview she conducted a few months ago: https://www.reddit.com/r/Supplements/comments/1jo8pk8/my_top...
Re: Sleep all comes down to the mitochondria
#198So the ancient mystery of why we need sleep might have just been answered. The paper shows that cell‑autonomous mild uncoupling in Drosophila sleep‑inducing neurons -- via Ucp4A/Ucp4C -- keeps the flies awake by lowering mitochondrial Δp and therefore electron leak. This suggests a biochemical rationale for sleep -- which is postponed by the uncoupler. That form of pharmacological manipulation is also a very local in…
> So the ancient mystery of why we need sleep might have just been answered. No, science doesn't work that way. The ancient mystery of why we need sleep has a new theory [1]. [1] I am assuming it is new. It might actually be old. I don't know.
a completely unnecessary interjection
"might have been answered" is absolutely valid: the correct theory might have been produced
Re: Sleep all comes down to the mitochondria
#199Earlier quoted context omitted.
yes, at night they breath oxygen. Maybe they sleep during the day.
But their cells still consume oxygen during the day, don't they? In sunshine they produce more oxygen than they consume, but the cells are still fundamentally powered by mitochondria oxidizing glucose
Perhaps different regions of the plant "sleep" at different times? The plant has no need for high response synchronized behavior at all.
Re: Sleep all comes down to the mitochondria
#200Earlier quoted context omitted.
It’s not clear to me CFS is really a thing. To me it’s a catch all BS diagnosis that basically says “we don’t know what this is, so we’re calling it CFS”.
It is definitely a thing. It all fits with the mitochondria theory: after physical or mental exhaustion (increased metabolic turnover provided by mitochondria) the recovery time (sleep) for ME/CFS patients is increased to such a degree that normal daily tasks gets them into a energy low they can't recover from anymore.
Except there isn't any evidence of mitochondria problems in ME/CFS, even though a lot of studies have looked at them.