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Bill Atkinson's psychedelic user interface

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Re: Bill Atkinson's psychedelic user interface

#261

Post by gavinray »

sneak wrote: post #234
firtoz wrote: post #20

Earlier quoted context omitted.

There are some decent communities in Discord, for both research oriented but also hobby oriented communities of psychedelics.

I can’t imagine discussing use and possession of Schedule 1 substances on a non-e2ee, logged-in-cleartext-forever platform. You’re opening yourself up to blackmail by hundreds of different parties. It is blatantly irresponsible to host such communities on Discord. Possession and use are federal felonies .

Well, don't join any of those discords lest your imagination be disappointed I suppose.

Most of the world is not so paranoid. Particularly psychedelic users who don't see the substances as a problem.

Re: Bill Atkinson's psychedelic user interface

#262

Post by gavinray »

zapzupnz wrote: post #224
diggan wrote: post #9

Earlier quoted context omitted.

> Ok, where is this psychedelic community found? Bit like asking where all the beer drinkers are! People who are into psychedelics come from all walks of life and we're everywhere :) Start talking about fringe stuff with people and eventually you'll stumble upon others.

I mean, it's not the same is it, because I can tell you where I can at least find beer drinkers … down the pub, at the bar. If your bubble has people in it who have access to psychedelics, then great. If one's people doesn't have that, "just talk to people" is profoundly unhelpful. That's a very odd and specific conversation to bring up within some circles.

You want to find psychedelic users?

Go hang out on TripSit IRC. Go to music shows that draw that sort of crowd, like Phish and Co or EDM shows.

Check out any of the psychedelics subreddits.

Some cities have public psychedelics meetups. This was huge in the Denver/Boulder area of Colorado.

There are lots of places if you try looking a little.

Re: Bill Atkinson's psychedelic user interface

#263

Post by gavinray »

notpushkin wrote: post #229
mosburger wrote: post #133

Earlier quoted context omitted.

Last year I underwent treatments for my treatment-resistant major depression using Ketamine. It was a clinical setting, where you'd get wired up to blood pressure, pulse-ox, and other monitors while you were monitored by an RN via video camera. This was IV Ketamine, so not the inhalants that are available now. According to the clinic, the inhalants (which they also offered) are also generally less effective than IV,…

> being able to "shut it off" was a good thing - you can turn an IV off, but once you inhale, you're on your own How does it work? Is the half-life of it shorter when administered IV?

I had a Ketamine infusion done at a clinic in Miami.

It was $600 (discounted) for the first infusion.

You go through a pre-evaluation with the doctor, where they determine a dosage for you based on prior experience and bodyweight.

My clinic also offered to co-administer IV benzos to prevent panic attacks or negative experiences, which was a HUGE plus for me.

During the experience you're given a button, which you can press to call them and have the drip turned off or turned down.

If it wasn't so expensive or covered by my insurance, I would've certainly repeated it.

Highly recommend.

Re: Bill Atkinson's psychedelic user interface

#264

Post by gavinray »

sneak wrote: post #236
mosburger wrote: post #133

Earlier quoted context omitted.

Last year I underwent treatments for my treatment-resistant major depression using Ketamine. It was a clinical setting, where you'd get wired up to blood pressure, pulse-ox, and other monitors while you were monitored by an RN via video camera. This was IV Ketamine, so not the inhalants that are available now. According to the clinic, the inhalants (which they also offered) are also generally less effective than IV,…

Fun fact: the cost of the ketamine in that $2000 treatment is about $1. Even factoring in trained staff to monitor, you’re up to a few hundred bucks for the hour. It’s mostly just the failings of the US medical establishment, and, of course, arbitrarily constrained supply that results in gouging. Just go buy $100 in street ketamine (still marked up 100x, fwiw, also because laws) from someone reputable, test it for fe…

You're much safer and cheaper buying Ketamine from the darknet via a reputable vendor.

You get to decide whether you want racemic or S-Ketamine, and your money is held in escrow until you've got the product and release the funds to the vendor.

Re: Bill Atkinson's psychedelic user interface

#265

Post by gavinray »

fnord77 wrote: post #209
_fat_santa wrote: post #30

We need to push to make this stuff legal. I wouldn't go so far as to say lets sell it OTC vape pens at gas stations but a middle ground where you can go to a doctor to have this treatment performed. I personally have never taken DMT though from everything I've read and heard on podcasts it's not something to be taken lightly. I think having a sort of "DMT Clinic" that you can go to would be the best middle ground of…

5-Meo is kind of nasty because it has a non-linear pharmacology. the normal dose is 5-10mg, but LD50 in sheep is about 100mg, it might be as low as 30mg in humans. It absolutely should not be legal, at least to anyone. Perhaps require training in dealing with drugs with a low therapeutic index

Tell me you never studied basic med chem or pharmacology without telling me...

You can't use animal models for dose, you have to convert to hED (Human-Equivalent Dosage). You can estimate this generally with allometric scaling:

https://drughunter.com/practical-pk-calculators

Also, animal physiology varies.

Beta-adrenergic agonists like clenbuterol make mice wildly muscular, which unfortunately is not the case in humans, for example.

Re: Bill Atkinson's psychedelic user interface

#266

Post by gavinray »

OldfieldFund wrote: post #230
fnord77 wrote: post #209

Earlier quoted context omitted.

5-Meo is kind of nasty because it has a non-linear pharmacology. the normal dose is 5-10mg, but LD50 in sheep is about 100mg, it might be as low as 30mg in humans. It absolutely should not be legal, at least to anyone. Perhaps require training in dealing with drugs with a low therapeutic index

LD50 in sheep: 1–5 mg/kg IV 1–2 mg/kg SC 85 mg/kg O In mice: 75–115 mg/kg IP 48 mg/kg IV 113 mg/kg SC 278 mg/kg O They were administering over 30mg to humans in trials. (Metzner (2013); Shulgin and Shulgin (1997); Ott (2001); Davis et al. (2018); Uthaug et al. (2020a)) Sheep are susceptible to toxicity from certain tryptamine alkaloids because of their physiology. These alkaloids, especially those that are N,N-dimeth…

The Human-Equivalent Dose for IV administration is roughly ~300mg for a 100kg human.

Re: Bill Atkinson's psychedelic user interface

#267

Post by gavinray »

colecut wrote: post #155
Bnichs wrote: post #153

Earlier quoted context omitted.

Can you explain how it changed after being a father?

I tripped a lot in my early 20s, a whole lot, and never had a bad time. Well, I had some uncomfortable experiences, but not what I can now call a bad trip. One of my first times after, in my experience, I literally went to hell. I was convinced I was on the outskirts, all the people at the party around me were demons, I was about to be tortured forever, and I was never going to see my son again and he was going to gr…

I've had remarkably similar bad trips, unfortunately I didn't make it out as unscathed.

I tell people: I had both the best day of my life, and the worst day of my life on psychedelics.

Re: Bill Atkinson's psychedelic user interface

#268

Post by gavinray »

Etheryte wrote: post #228
512 wrote: post #21

Earlier quoted context omitted.

> I know they will before that I'm curious in what demographic/location context you're in to say that. As a teen I wasn't aware of anyone in my social circles experimenting with drugs and would estimate usage to be <10% and from very particular kinds of people.

In general, interpolating statistics based on your personal world view is often misguided. Almost fifty percent of all Americans have tried drugs at least once in their lives [0], you simply won't know about it because most won't speak about it openly. Statistically you're unknowingly acquaintances with a number of people who fall into that category. To quote [1]: > By the time they’re in 12th grade, 46.6% of teens h…

I'd done multiple hard drugs well before I had sex for the first time, in the USA.

I guess that speaks a bit to the culture and availability of both things here in the States.

Re: Bill Atkinson's psychedelic user interface

#269

Post by notpushkin »

gavinray wrote: post #263
notpushkin wrote: post #229

Earlier quoted context omitted.

> being able to "shut it off" was a good thing - you can turn an IV off, but once you inhale, you're on your own How does it work? Is the half-life of it shorter when administered IV?

I had a Ketamine infusion done at a clinic in Miami. It was $600 (discounted) for the first infusion. You go through a pre-evaluation with the doctor, where they determine a dosage for you based on prior experience and bodyweight. My clinic also offered to co-administer IV benzos to prevent panic attacks or negative experiences, which was a HUGE plus for me. During the experience you're given a button, which you can…

Very interesting, thanks for sharing! I’ve read that you can get your hands on a solution for Ketamine injections (or, if you have pure Ketamine, just prepare one yourself). Most go for intra-muscular injections instead (~70% bioavailability compared to IV, still great compared to ~10% when snorted). The reason they give is, when administered IV it wears off way too quickly – I guess drip solves this one!

This is, of course, way more risky and pretty much illegal I guess, but it should probably be cheaper?

Re: Bill Atkinson's psychedelic user interface

#270

Post by gavinray »

notpushkin wrote: post #269
gavinray wrote: post #263

Earlier quoted context omitted.

I had a Ketamine infusion done at a clinic in Miami. It was $600 (discounted) for the first infusion. You go through a pre-evaluation with the doctor, where they determine a dosage for you based on prior experience and bodyweight. My clinic also offered to co-administer IV benzos to prevent panic attacks or negative experiences, which was a HUGE plus for me. During the experience you're given a button, which you can…

Very interesting, thanks for sharing! I’ve read that you can get your hands on a solution for Ketamine injections (or, if you have pure Ketamine, just prepare one yourself). Most go for intra-muscular injections instead (~70% bioavailability compared to IV, still great compared to ~10% when snorted). The reason they give is, when administered IV it wears off way too quickly – I guess drip solves this one! This is, of…

It'll be significantly cheaper, and assuming you purchase the Ketamine from a reputable source/vendor and use a test kit on it, the risk is comparatively "minimal".

Not necessarily "condoning" the behavior, so much as sharing harm-minimization info here:

For safe/sterile injection, you need three things, all cheaply + easily available on the internet.

1) Bacteriostatic water - https://www.amazon.com/bacteriostatic-water/s?k=bacteriostat...

2) Sealed, sterile vials for preparation of the solution - https://www.amazon.com/Sterile-Vial/s?k=Sterile+Vial

3) Insulin syringes. 29g 0.5" work well. https://www.amazon.com/s?k=29g+1cc+1%2F2+inch+insulin+syring...

See my comment in this thread about IM administration of 4-AcO-DMT for more info:

https://news.ycombinator.com/item?id=44535690

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