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Schizophrenia is the price we pay for minds poised near the edge of a cliff

psychiatrymargins.com

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Re: Schizophrenia is the price we pay for minds poised near the edge of a cliff

#21

Post by Throwaway42754 »

I have schizoaffective disorder, induced by a bad trip from marijuana. It was like the 3rd time I had tried weed, and I naively took too much.

For me psychosis feels like pattern matching going on extreme overdrive, while at the same time memory goes to shit. It's truly an awful illness, and what's worse is that the current medical treatments are bad. I've been fortunate enough where I can get by on a low dose olanzapine, but for many people they simply don't work at all.

Even though I'm doing well enough to function normally and hold down a good, well paying job, it's impossible to find a partner. If I were to have kids, I would have to go through one of the embryo prescreening services. I am strongly in support of these screening services - the disease is truly horrible.

There has been little progress on treatments for schizophrenia, the mechanism of action of these drugs has remained the same for decades. The side effects are almost as bad as the disease, which is why so many schizophrenic stop taking them. The only novel medication recently released is Cobenfy, which I have not tried yet.

Personally I am holding out hope that schizophrenia has some basis as an autoimmune disease. There was a cancer patient who had a bone marrow transplant and ended up being cured: https://www.nytimes.com/2018/09/29/opinion/sunday/schizophre...

Re: Schizophrenia is the price we pay for minds poised near the edge of a cliff

#22

Post by [deleted] »

JamesBarney wrote: post #5

If genes that increase schizophrenic risk increases cognitive abilities you should find people who have high polygenic scores for schizophrenia without having schizophrenia test well on these cognitive abilities. I'm not aware of any of data that shows this in a convincing matter. I think I've seen a few small studies but nothing that replicated this on a large scale. And most of the studies show they score worse on…

[deleted]

Re: Schizophrenia is the price we pay for minds poised near the edge of a cliff

#24

Post by cjbgkagh »

PaulHoule wrote: post #14
cjbgkagh wrote: post #7

I think people should study the RCCX gene cluster and link to giftedness more, I have TNXB SNPs which results in hEDS, but C4 SNPs have a similar effect and is likely to result in Schizophrenia. There are some cross over symptoms such as dopamine dysregulation and flat affect. I think dysautonomia and auto-immune plays a big part. Our lifestyles are very different than they used to be and this could be exacerbating a…

Is there some puzzling chronic condition that isn’t on this list? https://me-pedia.org/wiki/RCCX_Genetic_Module_Theory

Of course there are. I'm guessing you're insinuating two things, it's highly improbable that individuals can have this many simultaneous issues, and it's impossible for medical researchers to miss such an anomaly. The Ehlers Danlos subset is shorter but still covers a huge amount of issues (https://ohtwist.com/about-eds/comorbidities).

Well there is a reason why doctors kept telling me I am a hypochondriac, but I do have a whole zoo of conditions simultaneously, and this is a pretty common state for people with hEDS and I'm on the extreme end of it. So while milder versions of it are ~2% of the population the extreme versions of it are And yeah, medical researchers are in fact in the aggregate really bad at their jobs. Look how long it took to convince surgeons to wash their hands. But a lot of the genetic stuff relies on Linear Regression for GWAS which assumes independents of SNPs, otherwise you get multicollinearity problems, this is not a safe assumption and they've confused their results as confirming their assumptions. Instead of listing everything they get wrong a much shorter list is what they get right, Dr Jessica Eccles (https://x.com/BendyBrain) does great research into Long Covid and Generalized Joint Hypermobility which should put to bed the theory that GJH is benign - still good luck trying to talk a doctor out of that train of thought.

If you find someone who has hEDS the odds are they have a very large number of those things and most of them don't even know the names of most of the conditions, just one or two that bother them the most. The RCCX / hEDS list is a distinct subset of all possible things, the list of all medical maladies is far longer. It becomes highly improbable that a set of people have the same set of maladies - doctors tend to chalk this up to social contagion but that doesn't bear out. Genetic and behavioral causes have distinct diffusion patterns.

It's confirmable with WGS which I've done and I've encouraged many others to do and it turns out that you can indeed predict with a great deal of reliability if someone has TNXB / CYP21A2 SNPs. Unfortunately it's harder to find people who have C4 since they're likely to have schizophrenia.

Re: Schizophrenia is the price we pay for minds poised near the edge of a cliff

#25

Post by PaulHoule »

amanaplanacanal wrote: post #20
PaulHoule wrote: post #11

Earlier quoted context omitted.

Dangerous to the autism-industrial complex and as well as the addictive stimulant industry.

Is this supposed to be some kind of diss for adhd stimulant therapy?

Gotta a friend who’s 52 and has all his teeth rot out 10 years ago. He goes to Wegmans every month and comes back with a pill bottle the size of a small trashcan. He says he could get nothing done without out but I don’t see him getting anything done. Wouldn’t be surprised if will fall and break his hip 20 years early.

I’ve seen plenty of those pills get diverted with outcomes like somebody stays up for 4 days and gets hospitalized so, yeah, I want to diss ADHD medication. It is clear it helps in the short term, not so clear if it helps in the long term.

Re: Schizophrenia is the price we pay for minds poised near the edge of a cliff

#26

Post by DiscourseFan »

PaulHoule wrote: post #10
bad_haircut72 wrote: post #4

Earlier quoted context omitted.

I've never ever had any symptoms of schizophrenia but the idea of trying to consciously encourage myself hearing voices is terrifying, Im sure I could send myself truly insane with probably not much effort.

My belief about is that the core of schizotypy and schizophrenia is https://en.wikipedia.org/wiki/Thought_disorder as did Eugen Bleuler. I have a friend who is schizophrenic whose speech hardly makes sense and she is always calling people on the phone and carrying on nonsensical conversations. Somehow the general public is hung up on ‘hearing voices’ but I have never once heard a voice but under stress I (schizotypal…

It's like gang-stalking--its not that there's something being introduced, but rather that the subject sees relations that are not objective relations (like, for instance, the relation between temperature, pressure, and state change). Typically, however (and I can't imagine a case where this didn't happen), the relations are social in character--and since social relations are subjective to the extent that all the social world is not expressly a fact, it can be difficult to differentiate between an illusion and a reality: people imagine their partners are cheating on them, whether or not its true. And there are many things we do not know about the social world around us; but, statistically speaking, nobody has ever actually been gang-stalked.

Re: Schizophrenia is the price we pay for minds poised near the edge of a cliff

#27

Post by ChrisMarshallNY »

Throwaway42754 wrote: post #21

I have schizoaffective disorder, induced by a bad trip from marijuana. It was like the 3rd time I had tried weed, and I naively took too much. For me psychosis feels like pattern matching going on extreme overdrive, while at the same time memory goes to shit. It's truly an awful illness, and what's worse is that the current medical treatments are bad. I've been fortunate enough where I can get by on a low dose olanza…

I have family with that.

The most striking thing, is the absolute certainty of the thinking. They feel as if their thinking is crystal-clear, and that they are the only one that "sees the patterns."

Currently, they're doing well. I know of others, that are not so fortunate.

It seems that pot is about the worst thing that a schizoaffective/schizophrenic person can use. They are better off chewing tabs of acid. I've not used it in about 45 years, and I've heard that today's pot is a heck of a lot stronger than what I remember.

Re: Schizophrenia is the price we pay for minds poised near the edge of a cliff

#29

Post by fragmede »

PaulHoule wrote: post #25
amanaplanacanal wrote: post #20

Earlier quoted context omitted.

Is this supposed to be some kind of diss for adhd stimulant therapy?

Gotta a friend who’s 52 and has all his teeth rot out 10 years ago. He goes to Wegmans every month and comes back with a pill bottle the size of a small trashcan. He says he could get nothing done without out but I don’t see him getting anything done. Wouldn’t be surprised if will fall and break his hip 20 years early. I’ve seen plenty of those pills get diverted with outcomes like somebody stays up for 4 days and ge…

How scientific.

Re: Schizophrenia is the price we pay for minds poised near the edge of a cliff

#30

Post by gfody »

PaulHoule wrote: post #2

Why does no-one dare say "schizotypy?" https://en.wikipedia.org/wiki/Schizotypy

many people hear voices and experience symptoms of schizophrenia while managing to keep their cool and thrive amongst the nerts. hearing-voices.org is a support network for such people
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