Having said that, ketorolac is a very potent pain inhibitor, can be prescribed for 6 days, causes no dependence issues. Pretty sure can be prescribed more. Cheap, out of patent protection. Took it when broke my hand, it was a miracle of painkiller.
The first non-opoid painkiller
191–200 of 235 posts
Re: The first non-opoid painkiller
#192Earlier quoted context omitted.
I avoid it at all costs because of the possibility of liver damage. Ibuprofen seems to have the same effect without potentially serious side effects.
Ibuprofen is anti inflammatory which paracetamol isn't. IIRC this means ibuprofen can hide infections. I had a doctor friend who avoided its use as generic pain relief for that reason.
Re: The first non-opoid painkiller
#193I think the medical community needs to take more seriously that different people have different pain tolerances. My wife, daughter and I are very pain tolerant. Out of curiosity, I've turned down freezing for fillings and I even turned down some of pain meds before abdominal surgery. I've never taken the post op opioids, including when I had my impacted wisdom teeth removed. My other kid, on the other hand, is a whim…
wow I'm envious. I remember how much pimples hurt and I was astounded nobody warned me. This now makes me curious what the low pain tolerance to anxiety correlation is.
Re: The first non-opoid painkiller
#194Earlier quoted context omitted.
Given how common accidental paracetamol overdose is I think it’s perfectly reasonable.
Many very simple things can badly hurt or kill someone who doesn't take a few minutes to not be stupid about using them properly. Legislating with absurdities applied to all anything that possibly leads to completely individual harm because a few people can't take normal responsibility for themselves emphatically isn't reasonable.
Fifty thousand hospital visits per year
> isn’t reasonable
Fortunately this is not a popular opinion
Re: The first non-opoid painkiller
#195I think the medical community needs to take more seriously that different people have different pain tolerances. My wife, daughter and I are very pain tolerant. Out of curiosity, I've turned down freezing for fillings and I even turned down some of pain meds before abdominal surgery. I've never taken the post op opioids, including when I had my impacted wisdom teeth removed. My other kid, on the other hand, is a whim…
read some books on parenting
Re: The first non-opoid painkiller
#196Re: The first non-opoid painkiller
#197Earlier quoted context omitted.
You were born with innate high pain tolerance, but your daughter is a whimp because she didn’t win genetic lottery like you?
I think they're using it hyperbolically. As a parent (who also maybe has a high pain tolerance but I am a guy and we are famous for both thinking that and for not being pain tolerant) my daughter is currently like this including the earrings thing. It's more of a frustration but I know she will grow out of it as she's already gotten a lot better. I would imagine OP is in the same boat and is just letting off a little…
You'd think my comment's thesis that folks with lower tolerances should be respected and treated differently would have given the rhetorical device away.
Re: The first non-opoid painkiller
#198Earlier quoted context omitted.
The FDA interfering with informed consent between doctor and patient isn't something I find a source of complex feelings. The agency bears zero responsibility for the pain and suffering its caused by overcaution.
> The FDA interfering with informed consent between doctor and patient isn't something I find a source of complex feelings. Thalidomide. Patients (and often doctors) really don't have the skills or information to make an informed decision. They can however have 'feelings'. This is not the same thing.
Re: The first non-opoid painkiller
#199Earlier quoted context omitted.
Some people pratice self-mutilation to relief their depression. 20 something years ago I frequented a girl who was full of scars under her clothes, she was pretty good at finding plausible excuses for the scars (plausible to a 20yr old ignorant about that practice), one day she confessed that she did this to herself and that she was unable to stop... It's not a memory I tought I would revisit but your question made m…
20 something years ago I frequented a girl LOL, this thread just keeps on delivering.
Re: The first non-opoid painkiller
#200Earlier quoted context omitted.
I’ve never heard of this particular overdose. In the US it’s completely unmonitored and I’ve never heard of an overdose. I’m genuinely surprised.
“A study of cases of acute liver failure between November 2000 and October 2004 by the Centers for Disease Control and Prevention in the US found that paracetamol was the cause of 41% of all cases” from https://en.m.wikipedia.org/wiki/Paracetamol_poisoning
> In adults, single doses above 10 grams or 200 mg/kg of bodyweight, whichever is lower, have a reasonable likelihood of causing toxicity.
10g is 20 pills of the highest strength you'll find in a regular store. Excedrin brand "Extra Strength" is half of that, you'd have to be eating 40+ pills in 24 hours, or 20+ pills per day on multiple consecutive days. Most acetaminophen pills have 100-200 mg of the active ingredient.
You're missing the context:
> Intentional overdosing (self-poisoning, with suicidal intent) is frequently implicated in paracetamol toxicity.[25] In a 2006 review, paracetamol was the most frequently ingested compound in intentional overdosing.[26]
So, it's not that acetaminophen will kill that easily. It's just that of the easily available ways to kill yourself, it's distinctly the one that destroys the liver quick.