Live data from Hacker News

The first non-opoid painkiller

worksinprogress.news

181–190 of 235 posts

Re: The first non-opoid painkiller

#181
post #42

Earlier quoted context omitted.

Well, pain exists for a reason for animals to pay attention to things that are harming the body. If you remove the flag (pain), harm will continue.

That's a very real concern. A friend of mine has a higher than normal threshold for pain and have permanent injuries as a result. Among other things has walked around on a broken foot for months and failed to register a back injury. All of this then escalated to the point where she feels the pain, but the injuries have become permanent.

A rheumatologist explained to me that in people with chronic pain from things like arthritis, the brain's pain perception can become permanently altered to register pain that no longer "exists". She explained that the brain itself is really the source of the sensation of pain, and you don't necessarily need a "real" source producing a signal. So one should at least not ignore pain if one can avoid it.

Re: The first non-opoid painkiller

#183
post #113

Earlier quoted context omitted.

Off topic complaint: I am guessing an absolutely massive amount of (admittedly minor in each instance) grief has been caused by the most widely deployed simple, inexpensive, useful and familiar drug unnecessarily having two different names acetaminophen / paracetamol. Finally figured this out this year (aged 64) after previously being confused why I couldn't find any damn paracetamol in pharmacies on my occasional vi…

There was no grief in my case. I was recently in Italy with my mother. With a picture of a Tylenol bottle, before I could even utter sto cercando... , the pharmacist quickly gave her a box of something. I think it was called panadol.

Panadol is a household staple in Australia as well

Re: The first non-opoid painkiller

#184
post #124

Earlier quoted context omitted.

My wife and I got colds while vacationing in Edinburgh and had a heck of a time before realizing to ask for paracetamol rather than acetaminophen. Also, the rules the UK has for limiting paracetamol purchases to small amount per day are so fantastically stupid.

Given how common accidental paracetamol overdose is I think it’s perfectly reasonable.

Many very simple things can badly hurt or kill someone who doesn't take a few minutes to not be stupid about using them properly. Legislating with absurdities applied to all anything that possibly leads to completely individual harm because a few people can't take normal responsibility for themselves emphatically isn't reasonable.

Re: The first non-opoid painkiller

#185
post #2

Colloquially acetaminophen/paracetamol and ibuprofen are "painkillers" but this is in a different class, it's amazing to have something which performs like the opioid pain relief but without at least some of the side effects. It's the first non opioid painkiller applicable for situations like post operative use. I'd have loved this after my hernia op, the last thing you need with that is opioid induced constipation.

What kind of hernia ? In the US it seems like they prescribe opioids like candy. I've never heard of opioids post hernia surgery in Europe.

Right Side inguinal fixed with mesh. Yummy post op Opioids, bad constipation advice.

Re: The first non-opoid painkiller

#186

Earlier quoted context omitted.

I don't feel the title is misleading, but it may be a cultural language difference. The term 'painkiller' is reserved for strong pain relief, and wouldn't include things like ibuprofen. That made me think immediately of a non-opioid pain blocker not just a pain reliever.

> The term 'painkiller' is reserved for strong pain relief, In which dialect of English do you think this is true?

New England style American English

Re: The first non-opoid painkiller

#187
post #36
post #27

Earlier quoted context omitted.

What is this thread? Sticking a knife through your skin to the bone kills pain and is addictive?

Some people pratice self-mutilation to relief their depression. 20 something years ago I frequented a girl who was full of scars under her clothes, she was pretty good at finding plausible excuses for the scars (plausible to a 20yr old ignorant about that practice), one day she confessed that she did this to herself and that she was unable to stop... It's not a memory I tought I would revisit but your question made m…

20 something years ago I frequented a girl

LOL, this thread just keeps on delivering.

Re: The first non-opoid painkiller

#188
post #69
post #6

The title... Confuses me. Especially with a handful on non-opiod painkillers sitting in my history. Gabapentin? Heck, ibuprofen? Especially when the article itself compares it to ibuprofen: > If paracetamol and ibuprofen are inadequate for pain relief, Journavx can now be prescribed as the next alternative treatment, instead of mild- to moderate-strength opioids. "suitable for treating post-surgery pain" isn't someth…

Gabapentin is an anticonvulsants. Ibuprofen and paracetamol are anti-inflammatory. While they are effective at reducing pain, they are technically not "pain killers". The title is therefore correct.

Redescribing NSAIDs as "not technically painkillers", when that's one of their primary use cases, seems... Disingenuous at best.

Re: The first non-opoid painkiller

#189
post #124

Earlier quoted context omitted.

Given how common accidental paracetamol overdose is I think it’s perfectly reasonable.

Many very simple things can badly hurt or kill someone who doesn't take a few minutes to not be stupid about using them properly. Legislating with absurdities applied to all anything that possibly leads to completely individual harm because a few people can't take normal responsibility for themselves emphatically isn't reasonable.

It’s not theoretical. On one side of the ledger we have people dying horrible deaths, on the other side we have people who can’t have vast quantities of paracetamol on hand for no particular reason. If you do in fact need vast quantities of paracetamol for some reason, it can be prescribed.
Post reply on HN