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The first non-opoid painkiller

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Re: The first non-opoid painkiller

#151
post #114

Earlier quoted context omitted.

What parts of the US use paracetamol? I’ve lived on both coasts and the Midwest and haven’t ever seen anything but acetaminophen.

Wikipedia has it's acetaminophen in United States, Canada, Japan, South Korea, Colombia and Venezuela

Can confirm it is called acetaminophen in Canada

Re: The first non-opoid painkiller

#152
post #2

Colloquially acetaminophen/paracetamol and ibuprofen are "painkillers" but this is in a different class, it's amazing to have something which performs like the opioid pain relief but without at least some of the side effects. It's the first non opioid painkiller applicable for situations like post operative use. I'd have loved this after my hernia op, the last thing you need with that is opioid induced constipation.

Off topic complaint: I am guessing an absolutely massive amount of (admittedly minor in each instance) grief has been caused by the most widely deployed simple, inexpensive, useful and familiar drug unnecessarily having two different names acetaminophen / paracetamol. Finally figured this out this year (aged 64) after previously being confused why I couldn't find any damn paracetamol in pharmacies on my occasional vi…

I had a really bad first few days visiting the US the first time because of this

Re: The first non-opoid painkiller

#153

Earlier quoted context omitted.

My wife and I got colds while vacationing in Edinburgh and had a heck of a time before realizing to ask for paracetamol rather than acetaminophen. Also, the rules the UK has for limiting paracetamol purchases to small amount per day are so fantastically stupid.

As annoying as it is (and I agree it is fantastically annoying) much to my surprise admissions for paracetamol overdose to UK hospitals absolutely plummeted after purchasing restrictions were introduced. Score one for the nanny state.

Not sure what "plummeted" quantifies to in this context, but the US saw meaningful reductions in overdose treatments and calls to the poison control line after changing the labeling rules and a public education campaign. The cited study was even conducted before the full labeling rules change came into effect.

Teach a man why not to over-fish fish vs giving him a smaller amount of fish... or something.

https://pmc.ncbi.nlm.nih.gov/articles/PMC5676300/

Re: The first non-opoid painkiller

#154

Earlier quoted context omitted.

Off topic complaint: I am guessing an absolutely massive amount of (admittedly minor in each instance) grief has been caused by the most widely deployed simple, inexpensive, useful and familiar drug unnecessarily having two different names acetaminophen / paracetamol. Finally figured this out this year (aged 64) after previously being confused why I couldn't find any damn paracetamol in pharmacies on my occasional vi…

My wife and I got colds while vacationing in Edinburgh and had a heck of a time before realizing to ask for paracetamol rather than acetaminophen. Also, the rules the UK has for limiting paracetamol purchases to small amount per day are so fantastically stupid.

> Also, the rules the UK has for limiting paracetamol purchases to small amount per day are so fantastically stupid.

Its introduction pretty effectively reduced the incidence of suicide attempts by overdose resulting in death or hospitalisation.

https://pubmed.ncbi.nlm.nih.gov/23393081/

(The tl;dr conclusion: it worked, consider going further.)

Re: The first non-opoid painkiller

#155

I think the medical community needs to take more seriously that different people have different pain tolerances. My wife, daughter and I are very pain tolerant. Out of curiosity, I've turned down freezing for fillings and I even turned down some of pain meds before abdominal surgery. I've never taken the post op opioids, including when I had my impacted wisdom teeth removed. My other kid, on the other hand, is a whim…

You were born with innate high pain tolerance, but your daughter is a whimp because she didn’t win genetic lottery like you?

I think they're using it hyperbolically. As a parent (who also maybe has a high pain tolerance but I am a guy and we are famous for both thinking that and for not being pain tolerant) my daughter is currently like this including the earrings thing. It's more of a frustration but I know she will grow out of it as she's already gotten a lot better. I would imagine OP is in the same boat and is just letting off a little rhetorical steam.

Re: The first non-opoid painkiller

#156

I think the medical community needs to take more seriously that different people have different pain tolerances. My wife, daughter and I are very pain tolerant. Out of curiosity, I've turned down freezing for fillings and I even turned down some of pain meds before abdominal surgery. I've never taken the post op opioids, including when I had my impacted wisdom teeth removed. My other kid, on the other hand, is a whim…

read some books on parenting

Which ones worked for you?

Re: The first non-opoid painkiller

#157
post #6

The title... Confuses me. Especially with a handful on non-opiod painkillers sitting in my history. Gabapentin? Heck, ibuprofen? Especially when the article itself compares it to ibuprofen: > If paracetamol and ibuprofen are inadequate for pain relief, Journavx can now be prescribed as the next alternative treatment, instead of mild- to moderate-strength opioids. "suitable for treating post-surgery pain" isn't someth…

I found this New Yorker article to explain it well. https://www.newyorker.com/magazine/2025/06/02/the-radical-de...

Re: The first non-opoid painkiller

#159

I think the medical community needs to take more seriously that different people have different pain tolerances. My wife, daughter and I are very pain tolerant. Out of curiosity, I've turned down freezing for fillings and I even turned down some of pain meds before abdominal surgery. I've never taken the post op opioids, including when I had my impacted wisdom teeth removed. My other kid, on the other hand, is a whim…

wow I'm envious. I remember how much pimples hurt and I was astounded nobody warned me. This now makes me curious what the low pain tolerance to anxiety correlation is.

Re: The first non-opoid painkiller

#160

I'm always surprised that Kratom ( https://en.wikipedia.org/wiki/Mitragyna_speciosa ) doesn't come up more in these conversations. In addition to being a powerful painkiller, it helps manage opioid withdrawals. I believe it's still somewhat legal for consumption in the U.S., though other countries have been moving to ban it to varying degrees, since it can be used recreationally, though it isn't known to produce the…

Because it's an opioid?

It's not though
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