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The first non-opoid painkiller

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Re: The first non-opoid painkiller

#141

Post by pasc1878 »

zdragnar wrote: post #130
tim333 wrote: post #109

Earlier quoted context omitted.

Tylenol also. Virtually all drugs and chemical products go under a bunch of somewhat confusing names. I guess for marketing?

Tylenol is slightly different in this case, as it is merely a brand name widely associated with their most commonly sold medicine. Tylenol does also make other medications, but the majority of it contains acetaminophen/paracetamol. Acetaminophen and paracetamol are two names for the same generic chemical composition drug, which is why it is especially confusing. You can ask for aspirin or ibuprofen in any English spe…

I don't think that is correct re football. Football is an English invention. It then split into Association Football and Rugby football.

From Association Football we get soccer. So Football was first then soccer.

e.g. The Football Association was formed in 1863 and the first international match in 1872 was billed as International Foot-ball Match and then in small writing (Association Rules) before the term soccer was used.

Re: The first non-opoid painkiller

#142

Post by fifticon »

Marazan wrote: post #136
theoreticalmal wrote: post #82

Earlier quoted context omitted.

My wife and I got colds while vacationing in Edinburgh and had a heck of a time before realizing to ask for paracetamol rather than acetaminophen. Also, the rules the UK has for limiting paracetamol purchases to small amount per day are so fantastically stupid.

As annoying as it is (and I agree it is fantastically annoying) much to my surprise admissions for paracetamol overdose to UK hospitals absolutely plummeted after purchasing restrictions were introduced. Score one for the nanny state.

denmark has same rule, for same purpose and effect

Re: The first non-opoid painkiller

#143

Post by wiseowise »

mousethatroared wrote: post #126

I think the medical community needs to take more seriously that different people have different pain tolerances. My wife, daughter and I are very pain tolerant. Out of curiosity, I've turned down freezing for fillings and I even turned down some of pain meds before abdominal surgery. I've never taken the post op opioids, including when I had my impacted wisdom teeth removed. My other kid, on the other hand, is a whim…

You were born with innate high pain tolerance, but your daughter is a whimp because she didn’t win genetic lottery like you?

Re: The first non-opoid painkiller

#144

Post by StochasticLi »

mousethatroared wrote: post #126

I think the medical community needs to take more seriously that different people have different pain tolerances. My wife, daughter and I are very pain tolerant. Out of curiosity, I've turned down freezing for fillings and I even turned down some of pain meds before abdominal surgery. I've never taken the post op opioids, including when I had my impacted wisdom teeth removed. My other kid, on the other hand, is a whim…

read some books on parenting

Re: The first non-opoid painkiller

#145

Post by blangk »

Traubenfuchs wrote: post #106
ck2 wrote: post #68

Earlier quoted context omitted.

Oh ambroxol is very interesting! And a cheap generic Really appreciate you mentioning it https://pmc.ncbi.nlm.nih.gov/articles/PMC6494067/

Ambroxol has many interesting fringe applications. It potentiates antibiotic effect in lung infections, including tuberculosis, treats painful hyperacusis, trigeminal neuralgia, neuropathic pain, parkinson, gaucher disease... ...and what's this? We have a surprise guest! Ambroxol significantly reduces snoring and thus suddenly becomes a candidate for a medication half the population should take! https://www.researchg…

Too bad its generic I guess. The cynic in me says that's why it doesn't get the interest it deserves

Re: The first non-opoid painkiller

#146

Post by ChrisMarshallNY »

hallway_monitor wrote: post #102
bigfudge wrote: post #100

Earlier quoted context omitted.

You don't need to take that much. LD50 is surprisingly close to the normal dose, and possible to do if you don't realise that cold remedies contain it (or that aminocetophen and paracetamol are the same thing!)

I avoid it at all costs because of the possibility of liver damage. Ibuprofen seems to have the same effect without potentially serious side effects.

I know folks that got ulcers; from both ibuprofen, and Aleve.

I take acetaminophen, but only occasionally.

Re: The first non-opoid painkiller

#147

Post by StochasticLi »

hinkley wrote: post #139

No. Not even the 100th. Wikipedia: > At least 100 distinct phytocannabinoids have been isolated from cannabis, although only four (i.e., THCA, CBDA, CBCA and their common precursor CBGA) have been demonstrated to have a biogenetic origin.[6] It was reported in 2020 that phytocannabinoids can be found in other plants such as rhododendron, licorice and liverwort,[7] and earlier in Echinacea. Cannibinoid receptors are s…

They give me massive anxiety.

Re: The first non-opoid painkiller

#148

Post by StochasticLi »

pcthrowaway wrote: post #76

I'm always surprised that Kratom ( https://en.wikipedia.org/wiki/Mitragyna_speciosa ) doesn't come up more in these conversations. In addition to being a powerful painkiller, it helps manage opioid withdrawals. I believe it's still somewhat legal for consumption in the U.S., though other countries have been moving to ban it to varying degrees, since it can be used recreationally, though it isn't known to produce the…

Because it's an opioid?

Re: The first non-opoid painkiller

#149

Post by lq9AJ8yrfs »

ocrow wrote: post #121
hallway_monitor wrote: post #102

Earlier quoted context omitted.

I avoid it at all costs because of the possibility of liver damage. Ibuprofen seems to have the same effect without potentially serious side effects.

The drawback of Ibuprofen is that it tends to cause damage to stomach and intestinal linings. That's why you are advised to take with food and/or lots of water. You don't want it absorbing all in one place. Long term use exacerbates the effect, making it more likely to cause ulcers and eventually internal bleeding. My partner ended up in the hospital with a serious internal bleed caused by taking Ibuprofen daily for…

Ibuprofen is possibly worse than that, it seems that it may interfere with sex hormones. [1]

This 2017 study I found in 30s of searching is seemingly underpowered at n=30 or so, but the (preliminary) implication is awful enough that I won't give my boys ibuprofen at all. Out of abundance of caution.

They can have naproxen or acetaminophen instead -- we keep those out of reach and teach our children not to touch them without adults.

Perhaps there is some more recent research?

[1] https://www.pnas.org/doi/abs/10.1073/pnas.1715035115

Re: The first non-opoid painkiller

#150

Post by dghlsakjg »

xnorswap wrote: post #122
dspillett wrote: post #108

Earlier quoted context omitted.

> the rules the UK has for limiting paracetamol purchases to small amount per day are so fantastically stupid Worse than that: it is effectively per day per shop. In a very short space of time I can buy two packs in Boots, two in Tesco, two in Sainsbury, ooh look another small Tesco I'll get two there as well, two from Savers, two from SuperDrug, …

And yet the policy appears to have been effective in reducing overdoses.

Overdoses declined in the US, as well, where there are no limits on quantity, but there has been a campaign to educate and create better labeling practices for medication containing acetaminophen.

I think it's important to recognize that overdoses can be intentional or unintentional, and it isn't clear which ones will be affected by the policy of limiting purchase quantity per transaction.

https://pmc.ncbi.nlm.nih.gov/articles/PMC5676300/

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