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The first non-opoid painkiller

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Re: The first non-opoid painkiller

#21

Post by bheadmaster »

spwa4 wrote: post #17
ggm wrote: post #2

Colloquially acetaminophen/paracetamol and ibuprofen are "painkillers" but this is in a different class, it's amazing to have something which performs like the opioid pain relief but without at least some of the side effects. It's the first non opioid painkiller applicable for situations like post operative use. I'd have loved this after my hernia op, the last thing you need with that is opioid induced constipation.

It will have different side effects. Plus don't forget: even the "pain relief" provided by sticking a knife through your skin to the bone is addictive. So the side effect of addiction isn't going to go away.

> even the "pain relief" provided by sticking a knife through your skin to the bone is addictive

> the side effect of addiction isn't going to go away

While I agree with your conclusion itself, I disagree that the premise implies the conclusion. The main difference between suzetrigine and opioids, as explained in the article:

    Crucially, opioids don’t just kill pain: they also incite pleasure.
    When the mu opioid receptors present in the reward center of the
    brain are activated, this reduces the secretion of a neurotransmitter
    called GABA, which works to inhibit dopamine-producing neurons. As GABA
    release declines, dopamine spikes, lighting up the reward center and
    inducing pleasure.
The "pain relief" provided by sticking a knife though your skin to the bone is caused by endorphine, which functions similarly to opioids, and that's why it's addictive.

Since suzetrigine doesn't affect mu receptors in the brain, this mechanism doesn't apply.

But I'm almost sure it will have some other unintended side effects. Morphine had them, heroin had them, methadon had them... And each time the inventors were sure they didn't.

Re: The first non-opoid painkiller

#22

Post by reliablereason »

dwroberts wrote: post #19
reliablereason wrote: post #15

According to our psychological theories any sufficiently fast acting and strong painkiller will be addictive as long as it removes or reduces any type of pain. Seams strange if this one truly will not have "drug abuse" connected to it.

The impression I got from Wikipedia reading about this (suzetrigine) is that it’s not addictive because it acts on peripheral nerves and not directly in your brain

Given how scared people are of "addiction" the seller certainly would like that narrative and it might make sense from a withdrawal perspective. Which in turn has an effect on how addictive a drug is to a very large degree.

Re: The first non-opoid painkiller

#23

Post by aaron695 »

ggm wrote: post #2

Colloquially acetaminophen/paracetamol and ibuprofen are "painkillers" but this is in a different class, it's amazing to have something which performs like the opioid pain relief but without at least some of the side effects. It's the first non opioid painkiller applicable for situations like post operative use. I'd have loved this after my hernia op, the last thing you need with that is opioid induced constipation.

[dead]

Re: The first non-opoid painkiller

#24

Post by arethuza »

ggm wrote: post #2

Colloquially acetaminophen/paracetamol and ibuprofen are "painkillers" but this is in a different class, it's amazing to have something which performs like the opioid pain relief but without at least some of the side effects. It's the first non opioid painkiller applicable for situations like post operative use. I'd have loved this after my hernia op, the last thing you need with that is opioid induced constipation.

I broke a tooth because of kidney stones...

I had kidney stones last year, by far the most painful thing I have experienced, and got opioid based painkillers which made me constipated. To try and fix that I was eating some stoned prunes and it turns out one of them wasn't stoned and I damaged a tooth (it was weak anyway and needed replacement with an implant).

Re: The first non-opoid painkiller

#25

Post by szszrk »

OJFord wrote: post #9

I think a better title here than: > The first non-opoid [sic] painkiller might be: > The first non-opioid nociceptive pain-killer Nociceptive pain being that by actual damage to tissue, as opposed to neuropathic pain like a headache or inflammation that you might take a (non-opioid!) NSAID for. https://www.iasp-pain.org/resources/terminology/

Will that terminology explanation be a subtitle? :)

Re: The first non-opoid painkiller

#26

Post by api »

If you read the parts about the discovery, and how the trail went, you'll see how basic research into all kinds of things feed into innovations like this.

Which is why some bean counter or ideologue cutting this stuff will halt progress all over the place.

Re: The first non-opoid painkiller

#27

Post by skerit »

bheadmaster wrote: post #21
spwa4 wrote: post #17

Earlier quoted context omitted.

It will have different side effects. Plus don't forget: even the "pain relief" provided by sticking a knife through your skin to the bone is addictive. So the side effect of addiction isn't going to go away.

> even the "pain relief" provided by sticking a knife through your skin to the bone is addictive > the side effect of addiction isn't going to go away While I agree with your conclusion itself, I disagree that the premise implies the conclusion. The main difference between suzetrigine and opioids, as explained in the article: Crucially, opioids don’t just kill pain: they also incite pleasure. When the mu opioid recep…

What is this thread? Sticking a knife through your skin to the bone kills pain and is addictive?

Re: The first non-opoid painkiller

#28

Post by OJFord »

szszrk wrote: post #25
OJFord wrote: post #9

I think a better title here than: > The first non-opoid [sic] painkiller might be: > The first non-opioid nociceptive pain-killer Nociceptive pain being that by actual damage to tissue, as opposed to neuropathic pain like a headache or inflammation that you might take a (non-opioid!) NSAID for. https://www.iasp-pain.org/resources/terminology/

Will that terminology explanation be a subtitle? :)

Well my comment will still be here, and at least having the qualifier in the title is a pointer to look it up if needed, or to hint 'oh right ok it doesn't mean of all things, I guess paracetamol does not kill nociceptive pain, whatever that is'.

Re: The first non-opoid painkiller

#29

Post by bravesoul2 »

ggm wrote: post #2

Colloquially acetaminophen/paracetamol and ibuprofen are "painkillers" but this is in a different class, it's amazing to have something which performs like the opioid pain relief but without at least some of the side effects. It's the first non opioid painkiller applicable for situations like post operative use. I'd have loved this after my hernia op, the last thing you need with that is opioid induced constipation.

I also thought about epidural. Is that a non addictive way to give pain relief (extreme yes)

Re: The first non-opoid painkiller

#30

Post by biofox »

OJFord wrote: post #9

I think a better title here than: > The first non-opoid [sic] painkiller might be: > The first non-opioid nociceptive pain-killer Nociceptive pain being that by actual damage to tissue, as opposed to neuropathic pain like a headache or inflammation that you might take a (non-opioid!) NSAID for. https://www.iasp-pain.org/resources/terminology/

I'm a neuroscientist by training, and that doesn't match my understanding (although the definitions might have changed).

Inflammation would be an instance of nociceptive pain, and an NSAID would alleviate it by reducing the inflammation; and most tissue damage will result in inflammation.

Neuropathic pain, on the other hand, would be due to damage of the nerves themselves, and NSAIDs are completely useless here (ask anyone with sciatica or other nerve entrapment)

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