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Administering immunotherapy in the morning seems to matter. Why?

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Re: Administering immunotherapy in the morning seems to matter. Why?

#121

Post by vidarh »

vkou wrote: post #55
sixo wrote: post #50

Earlier quoted context omitted.

Amazing. And shameful (for them.)

> And shameful (for them.) 1. A single positive outcome with N=1 should generally not be the basis for making a medical recommendation. 2. It takes a mountain of research work to go from that to a study that you can draw meaningful conclusions from. 3. The hospital is not in the business of doing research, it's in the business of treating patients.

Given the scheduling was clearly not based on a medical recommendation in the first place given they were prepared to change it, then even a single datapoint suggesting it might have an impact should be reason to do at least minimal investigation into whether #3 might be better served by altering the schedule.

Since they clearly could alter the schedule, offering a limited number of later slots and comparing results would seem like the prudent response.

Re: Administering immunotherapy in the morning seems to matter. Why?

#122

Post by bloqs »

raylad wrote: post #48

My father was on chemotherapy with fludarabine, a dna base analog. The way it functions is that it is used in DNA replication, but then doesn’t work, and the daughter cells die. Typically, patients who get this drug experience a lot of adverse effects, including a highly suppressed immune system and risk of serious infections. I researched whether there was a circadian rhythm in replication of either the cancer cells…

As a younger person what are the best habits to get into to maintain optimal long term immune health?

Re: Administering immunotherapy in the morning seems to matter. Why?

#123

Post by darkwater »

dotancohen wrote: post #112
vlovich123 wrote: post #93

Earlier quoted context omitted.

If a study like this needs a complicated IRB approval or extra data collection vs what’s already being collected for health records, you’re doing it wrong and the process has become more important than the problem you’re trying to solve.

> the process has become more important than the problem you’re trying to solve. This holds true in almost every professional field for which life is on the line. Medicine, class 3 electronics, aviation. We have a word for this, which roughly translates to "rule of paperwork". Bureaucracy.

And I think there is a reason why the bureaucracy exists in these cases. "Move fast and break things" doesn't work very well there.

Re: Administering immunotherapy in the morning seems to matter. Why?

#124

Post by darkwater »

echelon wrote: post #111
cannonpr wrote: post #88

Earlier quoted context omitted.

You might be surprised at how little of the body still functions without brain function, well, some bits of the brain, including basic homeostasis and immune system function.

We're not at all trying. If you toss out the old rule book and provide unlimited funding, it can be made to work.

Yeah, sure. There are probably going to be only a few tens of thousands "unknown unknowns" side-effects but hey, who cares? We will figure them out, we are out of the stone age cave now!

Re: Administering immunotherapy in the morning seems to matter. Why?

#125

Post by Noelia- »

A while back, a colleague told me his doctor always scheduled his immunotherapy infusions for the morning, saying it would be more effective. I thought it was just something they said, but seeing all this new data, I’m realizing there’s actually real science behind it.

Re: Administering immunotherapy in the morning seems to matter. Why?

#126

Post by aitchnyu »

rendaw wrote: post #6

I'm doing CedarCure. You're required to not exercise or bath/shower for 2h after taking, which is fairly difficult in the morning, so I asked the doc if I could do it in the evening instead (despite explicit instructions to do it in the morning). The doc said it was fine, confirmed by the pharmacist. I should know better by now than to trust doctors to act based on research and not gut feeling, but I hope this doesn'…

From a lazy search, the measures are to trigger a reaction, but not intense enough send you to hospital. Fasted state (first thing in morning) can enhance absorption and avoid interference with food. (hot) showers cause vasodilation and exercise causes increased heart rate, both which increase allergen absorption enough trigger adverse reaction. If you have taken it for a year, your doctor may probably not worry about a too-intense reaction.

I'm also taking dust mite immunotherapy and assumed this article applies to me.

Re: Administering immunotherapy in the morning seems to matter. Why?

#127

Post by [deleted] »

echelon wrote: post #110
nothrabannosir wrote: post #102

Earlier quoted context omitted.

This comment, more than any other, has sold me on the value of red tape in medical research.

Our genome is a machine, from the nucleotides to the packing, to the enzyme activity, to the metabolic flux. Our bodies are bigger machines made of lots of little machines. Our minds or conscious egos or "souls" are the neurotransmitter and activation activity of the connectome and all of its cells and synaptic weights and metabolic activity. They're our lived experiences for as long as our brains can function. Minds…

[deleted]

Re: Administering immunotherapy in the morning seems to matter. Why?

#129

Post by ReptileMan »

bloqs wrote: post #122
raylad wrote: post #48

My father was on chemotherapy with fludarabine, a dna base analog. The way it functions is that it is used in DNA replication, but then doesn’t work, and the daughter cells die. Typically, patients who get this drug experience a lot of adverse effects, including a highly suppressed immune system and risk of serious infections. I researched whether there was a circadian rhythm in replication of either the cancer cells…

As a younger person what are the best habits to get into to maintain optimal long term immune health?

Normal weight and enough sleep.

Re: Administering immunotherapy in the morning seems to matter. Why?

#130

Post by short_sells_poo »

_qua wrote: post #89
xvector wrote: post #87

Earlier quoted context omitted.

I am close with a few folks in medical research and the broken nature of the system and sheer amount of red tape has broken their dreams. It is impossible to get anything done. There is a difference between "reasonable guardrails" and suffocating progress until it's nearly impossible barring Herculean efforts by multibillion dollar entities. It cannot be understated how badly the current bureaucracy has destroyed med…

I don’t disagree but the guy below you wants to grow human shells and try head transplants.

This is why we can't have nice things. I don't (mostly) doubt that poster's good intentions, but it takes only a few people with undirected ideas and flexible morals or empathy to necessitate strict rules around medical research.
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