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Administering immunotherapy in the morning seems to matter. Why?

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Re: Administering immunotherapy in the morning seems to matter. Why?

#11

Post by kelnos »

tines wrote: post #4
vhanda wrote: post #3

Earlier quoted context omitted.

From the article - > this paper was not a retrospective study of electronic health records, it was a randomized clinical trial, which is the gold standard. This means that we’ll be forced to immediately throw away our list of other obvious complaints against this paper. Yes, healthier patients may come in the morning more often, but randomization fixes that. Yes, patients with better support systems may come in the m…

What does randomization mean in this context, and why does it fix those problems?

Patients in the study are randomly assigned to the early group or the late group. They don't get to schedule their own appointments for whatever time of day they want.

Re: Administering immunotherapy in the morning seems to matter. Why?

#12

Post by detourdog »

rendaw wrote: post #6

I'm doing CedarCure. You're required to not exercise or bath/shower for 2h after taking, which is fairly difficult in the morning, so I asked the doc if I could do it in the evening instead (despite explicit instructions to do it in the morning). The doc said it was fine, confirmed by the pharmacist. I should know better by now than to trust doctors to act based on research and not gut feeling, but I hope this doesn'…

I looked up CedarCure and what I found is that it is a pesticide. What is the treatment about?

Re: Administering immunotherapy in the morning seems to matter. Why?

#13

Post by detourdog »

majormajor wrote: post #8
zevets wrote: post #2

This is bad science. Patients schedule when they go to immunotherapy appointments. People who go in the morning are still working/doing things, where once you get _really_ sick, you end up scheduling mid-day, because its such a hassle to do anything at all.

I always have seen mid-day appointments as also a luxury for those doing well (at least professionally/financially). If you have to go first thing in the morning, it's often because your boss wants you in relatively early and won't let you take time mid-day. If you're in a position where you can go in at 2PM and not have to sacrifice sleep to do so, that feels healthier. Given the highly-evident strong circular natur…

I can schedule appointments whenever I want. I'm an early riser and prefer my appointments first thing in the morning.

Re: Administering immunotherapy in the morning seems to matter. Why?

#14

Post by tines »

ajkjk wrote: post #10
tines wrote: post #4

Earlier quoted context omitted.

What does randomization mean in this context, and why does it fix those problems?

https://en.wikipedia.org/wiki/Randomized_controlled_trial The same thing it means in every context: that (with enough samples) you can control for confounders.

Supposing that patients did better in the morning because, say, the nurses were more alert, no matter how many samples you take you'll find the patients do better in the morning. How does "more samples" help control for confounders rather than just confirm a bias?

Re: Administering immunotherapy in the morning seems to matter. Why?

#15

Post by [deleted] »

vhanda wrote: post #3
zevets wrote: post #2

This is bad science. Patients schedule when they go to immunotherapy appointments. People who go in the morning are still working/doing things, where once you get _really_ sick, you end up scheduling mid-day, because its such a hassle to do anything at all.

From the article - > this paper was not a retrospective study of electronic health records, it was a randomized clinical trial, which is the gold standard. This means that we’ll be forced to immediately throw away our list of other obvious complaints against this paper. Yes, healthier patients may come in the morning more often, but randomization fixes that. Yes, patients with better support systems may come in the m…

[deleted]

Re: Administering immunotherapy in the morning seems to matter. Why?

#16

Post by tines »

kelnos wrote: post #11
tines wrote: post #4

Earlier quoted context omitted.

What does randomization mean in this context, and why does it fix those problems?

Patients in the study are randomly assigned to the early group or the late group. They don't get to schedule their own appointments for whatever time of day they want.

How does this control for the "alert nurses" variable? In that case, patients would do better in the morning, regardless of the patient.

Re: Administering immunotherapy in the morning seems to matter. Why?

#17

Post by justsomehnguy »

rendaw wrote: post #6

I'm doing CedarCure. You're required to not exercise or bath/shower for 2h after taking, which is fairly difficult in the morning, so I asked the doc if I could do it in the evening instead (despite explicit instructions to do it in the morning). The doc said it was fine, confirmed by the pharmacist. I should know better by now than to trust doctors to act based on research and not gut feeling, but I hope this doesn'…

There is always an option what taking it in the evening is magnitudes better than not taking it in the morning at all because you skipped it because you need a shower.

Always remember what you are just an another patient with your own quirks.

Re: Administering immunotherapy in the morning seems to matter. Why?

#18

Post by rendaw »

detourdog wrote: post #12
rendaw wrote: post #6

I'm doing CedarCure. You're required to not exercise or bath/shower for 2h after taking, which is fairly difficult in the morning, so I asked the doc if I could do it in the evening instead (despite explicit instructions to do it in the morning). The doc said it was fine, confirmed by the pharmacist. I should know better by now than to trust doctors to act based on research and not gut feeling, but I hope this doesn'…

I looked up CedarCure and what I found is that it is a pesticide. What is the treatment about?

It's an immunotherapy drug for cedar pollen allergy.

Re: Administering immunotherapy in the morning seems to matter. Why?

#19

Post by iamtheworstdev »

detourdog wrote: post #12
rendaw wrote: post #6

I'm doing CedarCure. You're required to not exercise or bath/shower for 2h after taking, which is fairly difficult in the morning, so I asked the doc if I could do it in the evening instead (despite explicit instructions to do it in the morning). The doc said it was fine, confirmed by the pharmacist. I should know better by now than to trust doctors to act based on research and not gut feeling, but I hope this doesn'…

I looked up CedarCure and what I found is that it is a pesticide. What is the treatment about?

looks like a sublingual immunotherapy treatment for allergies to japanese cedar pollen.

Re: Administering immunotherapy in the morning seems to matter. Why?

#20

Post by tines »

detourdog wrote: post #12
rendaw wrote: post #6

I'm doing CedarCure. You're required to not exercise or bath/shower for 2h after taking, which is fairly difficult in the morning, so I asked the doc if I could do it in the evening instead (despite explicit instructions to do it in the morning). The doc said it was fine, confirmed by the pharmacist. I should know better by now than to trust doctors to act based on research and not gut feeling, but I hope this doesn'…

I looked up CedarCure and what I found is that it is a pesticide. What is the treatment about?

OP is an insect going in for assisted suicide.
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