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Japanese scientists develop artificial blood compatible with all blood types

tokyoweekender.com

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Re: Japanese scientists develop artificial blood compatible with all blood types

#41

Post by ConradKilroy »

rockfishroll wrote: post #7

Biopure was a company doing something similar in the US. They imploded in the early 2000s, but they had created an "oxygen therapeutic" (blood substitute) by isolating hemoglobin based oxygen carrying molecules FROM COW BLOOD! The fact that they weren't using whole red blood cells meant the product was typeless, room temp stable, and better at perfusing around arterial blockages and into tissue since the molecules we…

I fondly remember trying to angel invest in BioPure, thank you for the flashback!

Re: Japanese scientists develop artificial blood compatible with all blood types

#42

Post by Nursie »

rockfishroll wrote: post #7

Biopure was a company doing something similar in the US. They imploded in the early 2000s, but they had created an "oxygen therapeutic" (blood substitute) by isolating hemoglobin based oxygen carrying molecules FROM COW BLOOD! The fact that they weren't using whole red blood cells meant the product was typeless, room temp stable, and better at perfusing around arterial blockages and into tissue since the molecules we…

How well did that one work?

There was another one in the US called "PolyHeme" which did not go well - https://en.wikipedia.org/?title=PolyHeme

The controversy around that one was not only that it did not work as well as it could (more patients had heart attacks than with saline), but that it was trialled on trauma patients without their explicit consent - implied consent was used, and people in trial areas could opt-out by requesting a bracelet. Problematic to say the least...

Re: Japanese scientists develop artificial blood compatible with all blood types

#43

Post by londons_explore »

Semaphor wrote: post #33
MobiusHorizons wrote: post #22

Earlier quoted context omitted.

I would imagine the IP was sold, especially if there was bankruptcy.

I think the question was why whoever picked it up didn’t do anything with it, which points towards it not just being an issue of incompetence, but maybe an underlying issue of the technology.

It's super common for UP to be sold for $1 to someone who has no intention to use it, just to have a larger defensive IP portfolio.

Re: Japanese scientists develop artificial blood compatible with all blood types

#44

Post by graynk »

k_sze wrote: post #24

It's odd. It seems like this is not the first Japanese team to have developped artificial blood. I did a quick search and it seems there was another team at least as early as 2019 ( https://web.archive.org/web/20201111233217/http://www.asahi.... ) So what's different this time? (Upon further examination, the 2019 team at the National Defense Medical College also had Dr Hiromi Sakai. So why is this news now?)

In your link they have only done tests on rabbits.

In this post they have already done some tests on humans and are now increasing the dosage since March.

> Small-scale studies began in 2022. Three groups of four healthy male volunteers aged 20 to 50 received a single intravenous injection of hemoglobin vesicles — artificial oxygen carriers that mimic the structure of red blood cells — in increasing amounts, up to 100 milliliters. While some participants experienced mild side effects, there were no significant changes in vital signs, including blood pressure. Building on that success, Sakai announced that his team was accelerating the process last July. In March, it started administering between 100 and 400 milliliters of the artificial blood cell solution to volunteers.

> If no side effects are confirmed, the trial will shift to examining the treatment’s efficacy and safety. It aims to put the artificial red blood cells into practical use by around 2030.

Re: Japanese scientists develop artificial blood compatible with all blood types

#45

Post by b112 »

derefr wrote: post #13
0cf8612b2e1e wrote: post #5

The artificial blood is created by extracting hemoglobin — a protein containing iron that facilitates the transportation of oxygen in red blood cells — from expired donor blood. It is then encased in a protective shell to create stable, virus-free artificial red blood cells. As these artificial cells have no blood type, there is no need for compatibility testing. Blood-derived synthetic. Still cool, but continues to…

Apparently their first target is soon-to-expire donor blood erythrocytes — which makes this essentially a (pretty major) scalability improvement in how far existing donor blood goes. However, that being said: hemoglobin’s just a protein. Recombinant hemoglobin isn’t overly challenging to produce — we do it already. (Currently mostly animal hemoglobin, for vegan meat — but it’s no different to produce human hemoglobin…

Soon to expire, eh?

I wonder if the recently dead qualify.

Re: Japanese scientists develop artificial blood compatible with all blood types

#46

Post by b112 »

voidUpdate wrote: post #40
az09mugen wrote: post #37

Earlier quoted context omitted.

"PFC solutions can carry oxygen so well that mammals, including humans, can survive breathing liquid PFC solution, called liquid breathing."

Liquid breathing has always sounded horrible to me, wouldn't it feel like you're drowning constantly?

For the first time in my life, I now have an apt analogy for having systemd on my servers.

Re: Japanese scientists develop artificial blood compatible with all blood types

#47

Post by jnovacho »

b112 wrote: post #45
derefr wrote: post #13

Earlier quoted context omitted.

Apparently their first target is soon-to-expire donor blood erythrocytes — which makes this essentially a (pretty major) scalability improvement in how far existing donor blood goes. However, that being said: hemoglobin’s just a protein. Recombinant hemoglobin isn’t overly challenging to produce — we do it already. (Currently mostly animal hemoglobin, for vegan meat — but it’s no different to produce human hemoglobin…

Soon to expire, eh? I wonder if the recently dead qualify.

Donated blood has a limited shelf life. So this is about the stocks the donation centers have. This tech can use the almost expired stocks to "recycle" the donations, instead of destroying it.

Re: Japanese scientists develop artificial blood compatible with all blood types

#50

Post by b112 »

jnovacho wrote: post #47
b112 wrote: post #45

Earlier quoted context omitted.

Soon to expire, eh? I wonder if the recently dead qualify.

Donated blood has a limited shelf life. So this is about the stocks the donation centers have. This tech can use the almost expired stocks to "recycle" the donations, instead of destroying it.

Yes, but what makes that life on the shelf, limited?

Would cavader blood still be viable, harvested an hour post death?

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