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Japanese scientists develop artificial blood compatible with all blood types

tokyoweekender.com

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Re: Japanese scientists develop artificial blood compatible with all blood types

#21

Post by HappyJoy »

rockfishroll wrote: post #7

Biopure was a company doing something similar in the US. They imploded in the early 2000s, but they had created an "oxygen therapeutic" (blood substitute) by isolating hemoglobin based oxygen carrying molecules FROM COW BLOOD! The fact that they weren't using whole red blood cells meant the product was typeless, room temp stable, and better at perfusing around arterial blockages and into tissue since the molecules we…

What happens to the IP when this happens? If the product works but wasn't supported by the right company how does it not get picked up by someone more competent?

Re: Japanese scientists develop artificial blood compatible with all blood types

#22

Post by MobiusHorizons »

HappyJoy wrote: post #21
rockfishroll wrote: post #7

Biopure was a company doing something similar in the US. They imploded in the early 2000s, but they had created an "oxygen therapeutic" (blood substitute) by isolating hemoglobin based oxygen carrying molecules FROM COW BLOOD! The fact that they weren't using whole red blood cells meant the product was typeless, room temp stable, and better at perfusing around arterial blockages and into tissue since the molecules we…

What happens to the IP when this happens? If the product works but wasn't supported by the right company how does it not get picked up by someone more competent?

I would imagine the IP was sold, especially if there was bankruptcy.

Re: Japanese scientists develop artificial blood compatible with all blood types

#23

Post by kylehotchkiss »

rockfishroll wrote: post #7

Biopure was a company doing something similar in the US. They imploded in the early 2000s, but they had created an "oxygen therapeutic" (blood substitute) by isolating hemoglobin based oxygen carrying molecules FROM COW BLOOD! The fact that they weren't using whole red blood cells meant the product was typeless, room temp stable, and better at perfusing around arterial blockages and into tissue since the molecules we…

They just pumped like straight hemoglobin in the blood and it worked? No antibody response? They didn’t just like fall apart? Creative. I like it.

Re: Japanese scientists develop artificial blood compatible with all blood types

#24

Post by k_sze »

It's odd. It seems like this is not the first Japanese team to have developped artificial blood. I did a quick search and it seems there was another team at least as early as 2019 (https://web.archive.org/web/20201111233217/http://www.asahi....)

So what's different this time?

(Upon further examination, the 2019 team at the National Defense Medical College also had Dr Hiromi Sakai. So why is this news now?)

Re: Japanese scientists develop artificial blood compatible with all blood types

#26

Post by KnuthIsGod »

"Three groups of four healthy male volunteers aged 20 to 50 received a single intravenous injection "

Tested in 12 people, once. Hmm...

"The artificial blood is created by extracting hemoglobin — a protein containing iron that facilitates the transportation of oxygen in red blood cells — from donor blood"

So needs blood as a raw material.

Re: Japanese scientists develop artificial blood compatible with all blood types

#28

Post by awinter-py »

guessing it's this liposome tech (same lead author, sakai): https://pubmed.ncbi.nlm.nih.gov/33845721/

more on what I assume is their hemoglobin prep process: https://pubmed.ncbi.nlm.nih.gov/30715862/

and if you want to make your own liposomes, instructions here https://pmc.ncbi.nlm.nih.gov/articles/PMC8234105/

Re: Japanese scientists develop artificial blood compatible with all blood types

#30

Post by elboru »

0cf8612b2e1e wrote: post #5

The artificial blood is created by extracting hemoglobin — a protein containing iron that facilitates the transportation of oxygen in red blood cells — from expired donor blood. It is then encased in a protective shell to create stable, virus-free artificial red blood cells. As these artificial cells have no blood type, there is no need for compatibility testing. Blood-derived synthetic. Still cool, but continues to…

“No need for compatibility testing” – I think that’s a really important feature. Not everyone can accept all types of blood. It becomes a real challenge when a person requires constant transfusions and can only accept one specific blood type.
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