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Sleep apnea pill shows striking success in large clinical trial

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Re: Sleep apnea pill shows striking success in large clinical trial

#121

Post by TremendousJudge »

polishdude20 wrote: post #110
Citizen8396 wrote: post #56

Earlier quoted context omitted.

Fluticasone can be especially helpful for people with allergies and/or OSA. "Intranasal fluticasone treatment may be useful for patients with nasal obstruction-related obstructive sleep apnea to improve sleep quality and limit daytime dysfunction." https://pubmed.ncbi.nlm.nih.gov/31521518/ "Intranasal steroids and montelukast did not decrease AHI; however, total sleep time and percent of stage R sleep significantly i…

I find the most effective nasal sprays also give me terrible withdrawal symptoms. Like, I'd use them for a few days at night, alternating nostrils and then when I stop, my nose is closed shut for the next few days.

Some nasal sprays have salt in them in addition to whatever drug they have, which unblocks the nose immediately but is extremely addictive. The ones that have just the drug don't have this issue in my experience

Re: Sleep apnea pill shows striking success in large clinical trial

#123

Post by robterrell »

sfink wrote: post #104

One thing that I've found very helpful, and wish my doctor had mentioned: when putting on the CPAP (nasal pillows in my case), time turning it one with your breathing such that the machine first kicks in during an inhale. That's it. It sounds trivial. But my biggest problem[1] with the CPAP is that it feels like it's smothering me. I can get more air in, faster, without the CPAP, and I still vividly remember the init…

I got a travel CPAP and it's been a huge unlock for me for international flights. Last flight I took to Europe I picked a 9 pm flight and had 6 hours of actual good sleep on the plane.

Re: Sleep apnea pill shows striking success in large clinical trial

#124

Post by cmrdporcupine »

petesergeant wrote: post #116
jonmagic wrote: post #107

After nearly 14 years of using a cpap ( https://theprogrammingbutler.com/blog/archives/2014/02/13/sl... ) and then bipap religiously I was able to switch away recently. All I do now is use now is a piece of kinesthetic tape to make sure my mouth stays closed and that somehow works. I’d just done another sleep study to see if I had options other than the bipap because it’s been filling me with air since I was intubate…

A similar fix for me was a nasal steroid taken every night. Got me off the CPAP

Any long term side-effects from that?

Re: Sleep apnea pill shows striking success in large clinical trial

#125

Post by ProllyInfamous »

I am a fattie (BMI 36.5). I also have sleep apnea. Wearing a CPAP, I couldn't ever get any sleep (toss&turner).

Things that've helped:

1) Using body pillows to force sleeping on side, which straightens the neck (versus face-down) — also lessens low-back pain

2) DENTAL GUARD (a 3D-printed plastic insert which form-fits my teeth, slightly opening jaw-angle/mouth)

3) Losing weight — YES, sleep apnea is worsened by excess weight

4) Pseudoephedrine (an hour before sleep) — but be careful cause too much and you won't ever sleep

YMMV; I am not a doctor (just fat guy with apnea).

Re: Sleep apnea pill shows striking success in large clinical trial

#126

Post by 13_9_7_7_5_18 »

dsego wrote: post #101
Citizen8396 wrote: post #40

Earlier quoted context omitted.

Simple solutions to complex problems often aren't solutions at all.

I didn't intend it like that, it's a lighthearted comment on a forum where people exchange ideas. Just wanted to share something that helped me with snoring and closing of the airways. Does every comment need to be a carefully calculated response that provides complex insights? Edit: It also occurs to me that a sleep apnea pill sounds like a simple solution to a complex problem if it actually works. And as I read it,…

[dead]

Re: Sleep apnea pill shows striking success in large clinical trial

#127

Post by err4nt »

ProllyInfamous wrote: post #125

I am a fattie (BMI 36.5). I also have sleep apnea. Wearing a CPAP, I couldn't ever get any sleep (toss&turner). Things that've helped: 1) Using body pillows to force sleeping on side, which straightens the neck (versus face-down) — also lessens low-back pain 2) DENTAL GUARD (a 3D-printed plastic insert which form-fits my teeth, slightly opening jaw-angle/mouth) 3) Losing weight — YES, sleep apnea is worsened by exces…

Thanks for sharing, I'll try some of these out!

Re: Sleep apnea pill shows striking success in large clinical trial

#128

Post by ProllyInfamous »

err4nt wrote: post #127
ProllyInfamous wrote: post #125

I am a fattie (BMI 36.5). I also have sleep apnea. Wearing a CPAP, I couldn't ever get any sleep (toss&turner). Things that've helped: 1) Using body pillows to force sleeping on side, which straightens the neck (versus face-down) — also lessens low-back pain 2) DENTAL GUARD (a 3D-printed plastic insert which form-fits my teeth, slightly opening jaw-angle/mouth) 3) Losing weight — YES, sleep apnea is worsened by exces…

Thanks for sharing, I'll try some of these out!

If you attempt body pillows, get TWO (so when you roll to other side you don't have to wake up in order to swap pillow placement). But the dental guard ($$$ — worth it, IMHO) is the best solution on my list (I'm sure CPAP is ideal, but if I ever even could fall asleep, I'd wake up de-masked).

Best of luck!

Re: Sleep apnea pill shows striking success in large clinical trial

#129

Post by conception »

aziaziazi wrote: post #46
bryanlarsen wrote: post #21

Earlier quoted context omitted.

My CPAP provides 3 massive life changing benefits: - a proper night's sleep - moisture that ensures I don't wake up with a massive sinus headache that destroys my morning - letting my partner have a proper night's sleep Any one of the 3 would be worth the minor inconveniences of a CPAP.

> letting my partner have a proper night's sleep I’m interested in this: how’s the CPAP noise perceived by the partners? I don’t snore and usually wake up quickly when doing the "apnea noise", stopping before waking her up. In the meantime I read that CPAP produce a a constant sound + an inconstant sound from the air coming in and out. She needs quietness to sleep and disturbing her sleep refrained me to try it out.…

Different ones have different sound profiles. Even the quietest isn’t my favorite so I use a https://getsnooz.com which are pricey but easily the best white noise machines I’ve used. The noise machine even on very quiet is enough to mask the inconsistent breathing sound. That’d be my best advice on it.

Re: Sleep apnea pill shows striking success in large clinical trial

#130

Post by garyclarke27 »

Llamamoe wrote: post #98
elric wrote: post #7

I swear CPAP wouldn't get such a bad rep if the media would stop using pictures of men with obscenely large full face masks. The most commonly used CPAP mask is probably the minimalist Resmed P10 [1]. It looks a lot less intimidating than a bulky full face mask. And in most cases, full face masks aren't needed (no sources to cite, but titrating to the correct pressure allows most people to breathe through their noses…

The problem with CPAP is that 40% of patients don't tolerate it even for the 4h/night defined as treatment compliance, while most of the rest use it less than the full duration of the night, with studies demonstrating that treatment compliance depends on efficacy. And this is for traditional OSA in men - people with Upper Airway Resistance Syndrome(mostly identical mechanism as OSA, less oxygen desaturation, more aro…

I never had a problem with adopting CPAP. It's been transformative for me, sleep quality is literally 10 times better than without, I wake up feeling awful if I have a nap without it. Why would someone keep a mask on for 4 hours, then take it off? does not make sense to me.
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