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Sleep apnea pill shows striking success in large clinical trial

science.org

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Re: Sleep apnea pill shows striking success in large clinical trial

#72

Earlier quoted context omitted.

I've been using CPAP for 10 years, and it's pretty much the best thing that ever happened to me! The morning after my first real sleep in ~5 years was an unreal improvement. It felt like I was snatched from my death bed and back to normal. I use the nostril mask, and it doesn't really bother me. The full face mask experience is a lot worse. PS Technically, it blows!

I started with full face -- I thought I needed to because I was a mouth breather at night. But with the nostril mask I breathe through my nose.

It's a common issue. If you breathe through your mouth at night, it's often because you can't get enough air because your airway is compromised. Once you add PAP, that problem goes away, and many people can revert to nasal breathing.

There is an adjustment period, turbinates can swell up from the extra airflow, and it might be uncomfortable for a while. And some people have such awful septum deviations that they're breathing through a straw. But most people are fine.

Re: Sleep apnea pill shows striking success in large clinical trial

#73
post #7

I swear CPAP wouldn't get such a bad rep if the media would stop using pictures of men with obscenely large full face masks. The most commonly used CPAP mask is probably the minimalist Resmed P10 [1]. It looks a lot less intimidating than a bulky full face mask. And in most cases, full face masks aren't needed (no sources to cite, but titrating to the correct pressure allows most people to breathe through their noses…

I’m almost totally unfamiliar with CPAP, and the mask you linked looks like something I’d never want to be stuck wearing every night. Now, I wouldn’t let appearances drive my use of a medical device, and I’d use it if a doctor said I should, but I doubt people’s opinions are being driven by the exact type of mask they see.

Re: Sleep apnea pill shows striking success in large clinical trial

#74
post #72

Earlier quoted context omitted.

I started with full face -- I thought I needed to because I was a mouth breather at night. But with the nostril mask I breathe through my nose.

It's a common issue. If you breathe through your mouth at night, it's often because you can't get enough air because your airway is compromised. Once you add PAP, that problem goes away, and many people can revert to nasal breathing. There is an adjustment period, turbinates can swell up from the extra airflow, and it might be uncomfortable for a while. And some people have such awful septum deviations that they're b…

I assumed that my need for CPAP was mostly because I'm old and overweight. But I've always been a mouth breather even when I wasn't overweight, so it seems it could be more than my weight issues.

Re: Sleep apnea pill shows striking success in large clinical trial

#76

Has anyone tried the "hostage tape" or similar to force breathing through your nose like Essential Craftsman discussed in his series of videos https://youtu.be/g8JzXEoT9LI?si=rVuZRoMrE_fwL0qv

I have been doing something like this, every day, for several years now. I started with a more gentle kind of tape that doesn't go over your lips. But after trying different kinds of tape, I just stick a small piece of medical tape over my lips now.

I don't have sleep apnea but had a tendency to breath through my mouth at night. It worked almost immediately for me. And what's more, after my body got used to it, I could have a stuffy nose before sleeping, stick on the tape, and when I lie down, my nose would clear up, like it was conditioned to do that.

10/10 would recommend

Re: Sleep apnea pill shows striking success in large clinical trial

#77

Earlier quoted context omitted.

There are already nasal and throat sprays that help. I use throat spray and it helps a lot for getting better sleep for me and wife.

Call me curious. Where do these sprays fall between homeopathy and verifiable? I used to use a CPAP but now use an approved dental appliance (fancy word for an expensive mouth guard that readjusts your jaw). I would incorporate a spray that actually helps, if only just a little.

It's verifiable. They act on your uvula by stiffening it. Nasal spray acts on this too, but it also decongests your nose. It's not helping for all reasons of snoring, but for me it helps a lot. Unfortunately, if I spray at 22, it typically works only until about 5 in the morning and next application is not that good, but it's much better than full night of snoring.

Re: Sleep apnea pill shows striking success in large clinical trial

#78
post #71

Zepbound is actually FDA approved for the treatment of sleep apnea. It’s helped me sleep much better after losing 60 pounds due to this drug.

These peptides are actually a cure because they treat the underlying disease upstream to many of these pathologies.

Re: Sleep apnea pill shows striking success in large clinical trial

#79
post #11

Earlier quoted context omitted.

Virtually any pill you have to take for life has negative side effects. Medicine made serious progress in all kind of ways but we don't have magic pills yet, even simple things like fixing a broken bone "only" has a 90-95% success rate without complications. Stay in shape, eat clean an exercise, once it's gone it's gone for good

Many people have high blood pressure in spite of being in the top percentage of health and fitness. It gets tiring seeing people blame it on lack of exercise. Genetics is a thing.

Sure, that being said 75% of the west is overweight or obese... which aggravates basically any illness you can think of. Statistically speaking the extreme vast majority of people with high blood pressure, or anything else for that matter, aren't in the top percentage of anything positive health or fitness related

Re: Sleep apnea pill shows striking success in large clinical trial

#80
“Atomoxetine also increases heart rate and diastolic blood pressure a little bit,”

This reminds me of some studies I read about weird uses for nicotine. Trials have been run where people with sleep apnea wore nicotine patches with a reduction in episodes. The theory is it keeps the brain stimulated allowing, paradoxically, people to get better sleep. Things like this: https://pubmed.ncbi.nlm.nih.gov/3965253/

Doctors have no desire in getting people hooked on nicotine though, even if there's a net benefit, so it's great if they're finding other medications for the task.

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