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Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

societyforscience.org

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Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#91
post #53
post #37

Earlier quoted context omitted.

They aren't doing it on their own. Most of these kids are working with established researchers who give them the shape of the project, as well as the tools and the expertise to accomplish it. More recently the US scientific funding bodies have had summer programs for kids who wouldn't otherwise get that kind of access, but it's still the exception. It takes more than a summer to do this kind of work. Edit: quick sear…

>these kinds of science fairs are fundamentally about access. Completely agree there, which kind of brings me to a related thought: One thing I do wonder is, if you look at a few hundred years ago a lot of the inventors in math, physics, engineering, were a tiny group of people with access to resources and education. You're always reading the same names. It seems if we as a society could decide that science is more i…

> if we gave more access, time and incentives to people we should be able to increase the amount of scientific results exponentially.

That's how ML research is - all you need is sufficient compute and some torrented training data. It gives rise to a new problem of drowning in the literature. I think we simply don't have the tooling and institutions to integrate simultaneous scientific advancements from any significant portion of the population.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#92

Earlier quoted context omitted.

It's for this reason in the UK paracetamol (as we call acetaminophen) is only ever manufactured to 500mg tablets. I don't know if that is global.

Do you guys have liquid forms, especially for children where the dosage is, obviously, entirely up to you? One memory I have of visiting our U.S. head office with a bunch of UK people was the “we have to get to Target because they sell Tylenol in ungodly quantities.” And I thought bottles of 200 pills felt ridiculous up here in Canada.

Yeah, you can get lower doses. It turns out I was wrong and you can get 1g, but my understanding is it's not used in routine healthcare (for obvious reasons). https://bnf.nice.org.uk/drugs/paracetamol/medicinal-forms/#o...

I'd be interested to know if I'm wrong though.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#93

Earlier quoted context omitted.

Do you guys have liquid forms, especially for children where the dosage is, obviously, entirely up to you? One memory I have of visiting our U.S. head office with a bunch of UK people was the “we have to get to Target because they sell Tylenol in ungodly quantities.” And I thought bottles of 200 pills felt ridiculous up here in Canada.

Yeah, you can get lower doses. It turns out I was wrong and you can get 1g, but my understanding is it's not used in routine healthcare (for obvious reasons). https://bnf.nice.org.uk/drugs/paracetamol/medicinal-forms/#o... I'd be interested to know if I'm wrong though.

It feels like it’s quite simply a sensible approach to normalize as much as possible.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#94

Earlier quoted context omitted.

It’s unfortunate that it doesn’t work for you. Personally, I’ve never experienced a pharmaceutical that worked so reliably and predictably. It would bring a fever down in my kids when they were young without fail in about 25 minutes. To be fair though I really haven’t been involved with more than a handful of medications. I’m sure there’s many that work very crisply.

Similar to you it is incredible at bringing down fever in my kid. I've seen my kid go from whimpering looking like death, to be crawling about playing happily again in half an hour. With the behaviour change tracking with her temperature coming down. As an adult using it as a pain killer it has been ineffective.

For me I’ve found it works incredibly well at killing a headache or outright stopping a scintillating migraine (especially when combined with caffeine). But for body aches and pains I also find it doesn’t do a whole lot, especially compared to ibuprofen.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#95
post #59
post #53

Earlier quoted context omitted.

>these kinds of science fairs are fundamentally about access. Completely agree there, which kind of brings me to a related thought: One thing I do wonder is, if you look at a few hundred years ago a lot of the inventors in math, physics, engineering, were a tiny group of people with access to resources and education. You're always reading the same names. It seems if we as a society could decide that science is more i…

Meh. While I think the broad theme is fine (more access to education is generally good -- particularly when it comes to scientific literacy amongst the general public!), I think trying to encourage "research" in this way is largely pushing on a string. I can never figure out if this whole phenomenon of "science fairs" is just Kabuki theater for everyone involved, or if there's a core group of deeply deluded organizer…

Eh. Even if 1 in 10000000 of the kids that do "science fairs" end up in "science research" with at least one "scientific innovation", and the rest of them make $$$ in industry, that's them working. This comment is asinine on too many levels to fully rebut.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#96
post #66

Earlier quoted context omitted.

You die from liver failure. Which is a horrible way to die. You’re bleeding and clotting at the same time. Your abdomen swells with fluid. Then your legs and your whole body. Your skin turns yellow and you’re itching constantly. You become increasingly confused and violent. Infections start brewing in that pool of fluid in your abdomen.

I am going to cancel my internet subscription...

You should sign up for Nautilus. Monthly compact discs mailed to your door containing 650MB of assorted interactive multimedia. It was the original broadband (with very large packet size.)

(You might need a Time Machine first)

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#97
post #59

Earlier quoted context omitted.

Meh. While I think the broad theme is fine (more access to education is generally good -- particularly when it comes to scientific literacy amongst the general public!), I think trying to encourage "research" in this way is largely pushing on a string. I can never figure out if this whole phenomenon of "science fairs" is just Kabuki theater for everyone involved, or if there's a core group of deeply deluded organizer…

Eh. Even if 1 in 10000000 of the kids that do "science fairs" end up in "science research" with at least one "scientific innovation", and the rest of them make $$$ in industry, that's them working. This comment is asinine on too many levels to fully rebut.

Agreed, I don't believe the science fair will push research, but we need to lay the groundwork to build a society of researchers instead one of office drones, going through JIRA tickets.

The comment above yours is a really poor strawmanning attempt.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#98
post #59

Earlier quoted context omitted.

Meh. While I think the broad theme is fine (more access to education is generally good -- particularly when it comes to scientific literacy amongst the general public!), I think trying to encourage "research" in this way is largely pushing on a string. I can never figure out if this whole phenomenon of "science fairs" is just Kabuki theater for everyone involved, or if there's a core group of deeply deluded organizer…

> not due to inequity, but because only someone well-off could devote their lives to something so erratic. Aren't those effectively the same thing? At least in the given context where society doesn't have the resources available for everyone to live like that.

[deleted]

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#99

Earlier quoted context omitted.

It's for this reason in the UK paracetamol (as we call acetaminophen) is only ever manufactured to 500mg tablets. I don't know if that is global.

You can get 1000mg tablets but only if prescribed by a doctor

My doc wouldn't prescribe 1000s for me. I took two 600s (severe pain was kept at bay).
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