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Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

societyforscience.org

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Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#71

Post by 14 »

Glyptodon wrote: post #33
14 wrote: post #32

Earlier quoted context omitted.

Seeing articles like this is almost hard to read. My kids are very smart but this girl is 1000 times what they are doing. This girl is 1000 times what I am doing. Maybe it is just imposter syndrome but sometimes I read articles like this and think I fell short in life. But I am also top of my peers at work and I am a health care provider and my clients all request me so I know I am doing good. Sometimes I just wonder…

My experience is that stuff like this isn't because someone is wildly smarter than everyone but because there are connections, support, and resources of some form.

I understand that and I do know that I am actually very intelligent and smart. Same for my children I mean damn I have already taught my 8 year old how to solder as good as a professional and am working on programming with him. And as a health care worker I can look after even the most difficult complex care clients where other health care workers struggle. That is what I am known for at work. But sometimes seeing literal teens doing things that seem so far ahead of me it

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#72

Post by nenaoki »

14 wrote: post #32
ItsHarper wrote: post #2

This would be incredibly cool if it works in reality and not just simulation. Remarkable that the author is just 17.

Seeing articles like this is almost hard to read. My kids are very smart but this girl is 1000 times what they are doing. This girl is 1000 times what I am doing. Maybe it is just imposter syndrome but sometimes I read articles like this and think I fell short in life. But I am also top of my peers at work and I am a health care provider and my clients all request me so I know I am doing good. Sometimes I just wonder…

it's sad to compare.

apart from that: the word "mark" comes from a root for "boundary" or "border", and really it doesn't need to be about that; we're all in this together.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#73

Post by petesergeant »

Mizza wrote: post #3

She didn't even break the top 10 in this content: https://www.societyforscience.org/regeneron-sts/2025-student... I'm impressed beyond words by these kids, though I think I'd give her the top prize. Watching my grandfather's final days taken away from him by the effects of morphine has always made me wish so much that we had much more effective non-narcotic painkillers

Journavx!

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#74

Post by pipes »

porphyra wrote: post #43

It's always weird to me that acetaminophen has such a low therapeutic index, like in order to get enough for it to do anything, you're also on the verge of liver failure (especially if you also drink alcohol). Also it just doesn't work super well in my personal experience --- I hardly feel anything when I take it. And yet it's one of the most commonly taken medicines worldwide.

Calpol in the UK, paracetamol for children in liquid form (which is British name for acetaminophen) works wonders for kids with a fever. I'm not exaggerating when I say that every doctor I've seen with my kids has said not to withhold it as it really helps with fever.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#75

Post by meew0 »

nandomrumber wrote: post #57

Can acetaminophen be packaged with n-acetyl cysteine to render it not rate limited by same?

The problem is that N-acetylcysteine tastes and smells awful (like farts/rotten eggs) and often causes nausea and vomiting as a side effect.

The vast majority of people use acetaminophen in a safe way, and acetaminophen doesn't really have many side effects by itself, so you'd make life more unpleasant for a large number of people in order to prevent a tiny number of acute poisonings.

Probably if this were implemented, most acetaminophen users would switch to e.g. ibuprofen which is less acutely toxic in overdose but has much more chronic toxicity (to the stomach and the kidneys) when used over a long period of time, even at a normal dose. I'd wager this change might even be a net negative on the whole.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#76

Post by cluckindan »

Ey7NFZ3P0nzAe wrote: post #64
MichaelRo wrote: post #54

Earlier quoted context omitted.

Well, it doesn't work for high fever (> 39-40 Celsius). For that, I alternate Ibuprofen and sodium metamizole every 4 hours. For pain release, paracetamol it's very modest. Some effect for light head pain, zero for strong pain. Zero effect for strong back pain. Ibuprofen works better in all these cases but comes with stomach damage if taken for long.

Paracetamol is nicely synergic with all known painkillers. For example prescribing it with morphine leads to less morphine consumption. Also: it's a terrible rule of thumb to take an NSAID routinely for general infectious symptoms like fever.

Prescribing cannabis for pain also leads to less morphine consumption.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#77

Post by pasc1878 »

hgomersall wrote: post #69
Ey7NFZ3P0nzAe wrote: post #61

Earlier quoted context omitted.

It's terrible that you are counting in tablets instead of actual amount of acetaminophen

It's for this reason in the UK paracetamol (as we call acetaminophen) is only ever manufactured to 500mg tablets. I don't know if that is global.

You can get 1000mg tablets but only if prescribed by a doctor

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#78

Post by masklinn »

hgomersall wrote: post #69
Ey7NFZ3P0nzAe wrote: post #61

Earlier quoted context omitted.

It's terrible that you are counting in tablets instead of actual amount of acetaminophen

It's for this reason in the UK paracetamol (as we call acetaminophen) is only ever manufactured to 500mg tablets. I don't know if that is global.

1000mg is readily available around here, and although 500s are splittable you’ll find the odd 200~250 (mostly for children I assume).

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#79

Post by [deleted] »

chistev wrote: post #58
dreamcompiler wrote: post #51

Earlier quoted context omitted.

Two tablets work great for me for headaches but results do vary. The danger zone for liver damage is roughly 14 tablets taken all at once. (Less if you've been drinking.) From what I'm told, acetaminophen overdose is quite an unpleasant way to die.

The maximum single dose of paracetamol is 1000 mg, and four doses (4000 mg) in 24 hours. Any more and it's liver damage.

[deleted]

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#80

Post by [deleted] »

dogtorwoof wrote: post #62
dreamcompiler wrote: post #51

Earlier quoted context omitted.

Two tablets work great for me for headaches but results do vary. The danger zone for liver damage is roughly 14 tablets taken all at once. (Less if you've been drinking.) From what I'm told, acetaminophen overdose is quite an unpleasant way to die.

You die from liver failure. Which is a horrible way to die. You’re bleeding and clotting at the same time. Your abdomen swells with fluid. Then your legs and your whole body. Your skin turns yellow and you’re itching constantly. You become increasingly confused and violent. Infections start brewing in that pool of fluid in your abdomen.

[deleted]
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