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Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

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41–50 of 160 posts

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#41
post #12

This would be incredibly cool if it works in reality and not just simulation. Remarkable that the author is just 17.

I’m not going to shit on it, nothing wrong with going into the family business - but it isn’t a complete coincidence that her dad is a PhD biochemist at UT Tyler.

And look at her mother -- https://profiles.unthsc.edu/profile/381 -- hmmm

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#42
post #5

so is this already patented by Regeneron?

They would need to show efficacy to patent it. It seems like this is all computational.

Only for a utility patent, not for a composition of matter patent.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#43
It's always weird to me that acetaminophen has such a low therapeutic index, like in order to get enough for it to do anything, you're also on the verge of liver failure (especially if you also drink alcohol). Also it just doesn't work super well in my personal experience --- I hardly feel anything when I take it. And yet it's one of the most commonly taken medicines worldwide.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#44

It's always weird to me that acetaminophen has such a low therapeutic index, like in order to get enough for it to do anything, you're also on the verge of liver failure (especially if you also drink alcohol). Also it just doesn't work super well in my personal experience --- I hardly feel anything when I take it. And yet it's one of the most commonly taken medicines worldwide.

I take it mostly as an anti-pyretic (fever reducer). For which it is extremely effective. It's my drug of choice for colds, flu, etc.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#45
post #32

Earlier quoted context omitted.

Seeing articles like this is almost hard to read. My kids are very smart but this girl is 1000 times what they are doing. This girl is 1000 times what I am doing. Maybe it is just imposter syndrome but sometimes I read articles like this and think I fell short in life. But I am also top of my peers at work and I am a health care provider and my clients all request me so I know I am doing good. Sometimes I just wonder…

it's just a four step synthesis. with the help of a phd chemist you could probably learn the steps in three months, and if you put your mind to it you could learn the ochem in a year. this project is the culmination of at least a year-maybe even up to three-of work. whats surprising is that parents let their kids do ochem at 17!! thats some toxic shit :). safety is why chemistry is not a super popular field at high s…

C'mon, who doesn't like their kids dusted with methylmercury?

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#46
I'm not an expert in pharmaceutical chemistry, but this looks like a series of relatively complex and low yield reactions. Would it be likely that this would push the price of this product beyond what is reasonable for a general use drug?

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#47
post #18

Earlier quoted context omitted.

I thought morphine didn't cause health damage to the human body apart from addiction and withdrawal symptoms.

Well it absolutely muddles your mind when you're on it and it causes constipation. It can also depress your respiratory system.

And it can make some people very nauseous.

Nobody discusses these mundane drawbacks when they talk about the evils of heroin addiction. When you're high, you puke and you cannot give a shit. Both figuratively and literally.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#48
post #18

Earlier quoted context omitted.

I thought morphine didn't cause health damage to the human body apart from addiction and withdrawal symptoms.

at least according to these people [0], you can overdose on morphine, same as any opiate or opioid. not sure their credentials but it makes sense; it's an opioid/opiate and those can cause respiratory depression. [0] https://www.addictiongroup.org/drugs/opioids/morphine/overdo...

Oh yeah morphine overdose will kill you dead because you will stop breathing and you won't even know it happened.

The instant antidote is Narcan which is available over the counter at pharmacies in some states.

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#49
post #18

Earlier quoted context omitted.

I thought morphine didn't cause health damage to the human body apart from addiction and withdrawal symptoms.

Nurses in palliative care and hospice are well-known to generously administer morphine in increasing doses, because it eventually takes away all the pain and suffering (of the families and nurses).

That’s a controversial take

Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy

#50

I'm not an expert in pharmaceutical chemistry, but this looks like a series of relatively complex and low yield reactions. Would it be likely that this would push the price of this product beyond what is reasonable for a general use drug?

The starting point is ~free (like 2 or 4 cents retail per dose for generic in the US). Given my relatively light usage of pain drugs, I would certainly pay 10x that for reduced toxicity.

And then it isn't necessarily the case that the identified reactions are the most cost effective available.

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