Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy
societyforscience.org
Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy
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Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy
#2This would be incredibly cool if it works in reality and not just simulation. Remarkable that the author is just 17.
Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy
#3She didn't even break the top 10 in this content: https://www.societyforscience.org/regeneron-sts/2025-student...
I'm impressed beyond words by these kids, though I think I'd give her the top prize. Watching my grandfather's final days taken away from him by the effects of morphine has always made me wish so much that we had much more effective non-narcotic painkillers
Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy
#4impressive for a high schooler but this just adds a protecting group onto tylenol. am i missing something?
edit: oh i see. its really blurry but the silyl modified tylenol is predicted to have good trpv1 binding computationally. afaict no in vitro or in vivo studies were done. could be cool. not sure if diethylethynylphenylsilyl group has good Lipinski properties though (i suspect not)
edit: s/aspirin/Tylenol
Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy
#5so is this already patented by Regeneron?
Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy
#6impressive for a high schooler but this just adds a protecting group onto tylenol. am i missing something? edit: oh i see. its really blurry but the silyl modified tylenol is predicted to have good trpv1 binding computationally. afaict no in vitro or in vivo studies were done. could be cool. not sure if diethylethynylphenylsilyl group has good Lipinski properties though (i suspect not) edit: s/aspirin/Tylenol
It isn't aspirin - Acetaminophen, also known as N-acetyl-para-aminophenol (APAP) or paracetamol
Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy
#7She didn't even break the top 10 in this content: https://www.societyforscience.org/regeneron-sts/2025-student... I'm impressed beyond words by these kids, though I think I'd give her the top prize. Watching my grandfather's final days taken away from him by the effects of morphine has always made me wish so much that we had much more effective non-narcotic painkillers
https://www.societyforscience.org/press-release/regeneron-is...
She's in top 4, awarded $600? I dunno this is a confusing layout/structure for how the program is conducted seeing as how the headline is $9m awarded.
Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy
#8The same website is also for the excellent Science News print magazine, which will ship you top notch science reporting right to your door. My father was a subscriber since, well, whenever blue LEDs were invented, because I recall reading about them in Science News.
Strong recommendation for any science-lover.
Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy
#9impressive for a high schooler but this just adds a protecting group onto tylenol. am i missing something? edit: oh i see. its really blurry but the silyl modified tylenol is predicted to have good trpv1 binding computationally. afaict no in vitro or in vivo studies were done. could be cool. not sure if diethylethynylphenylsilyl group has good Lipinski properties though (i suspect not) edit: s/aspirin/Tylenol
It isn't aspirin - Acetaminophen, also known as N-acetyl-para-aminophenol (APAP) or paracetamol
lol yeah sorry brain too deep into synthetic chemistry bits. thanks.
Re: Modification of acetaminophen to reduce liver toxicity and enhance drug efficacy
#10so is this already patented by Regeneron?
regeneron is the sponsor of STS. used to be well known as the Westinghouse STS, then intel took it over in the aughts