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Delete your comment. You're minimising the death of children. Yeah I'm sensitive about this. I like many other parents of children who have been lost to genetic disease have good reason to be.
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Baby is healed with first personalized gene-editing treatment
131–140 of 570 posts
Re: Baby is healed with first personalized gene-editing treatment
#132Earlier quoted context omitted.
Unfortunately a staggering amount of research in other countries is largely funded by the NIH/USA.
And so what?
That means that it's not going to happen anymore.
Unless those other countries step up and fund it themselves.
They might. They might not.
Re: Baby is healed with first personalized gene-editing treatment
#133Earlier quoted context omitted.
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The anti-eugenics guy just said he would "absolutely" murder a baby...?
I would if I can foresee the future. But with eugenics you can't foresee the future. Self artificially selecting for genetic traits doesn't guarantee a good future. There's no gene for recreating Hitler either.
Re: Baby is healed with first personalized gene-editing treatment
#134Earlier quoted context omitted.
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A baby Hitler gaurantees a future with a grown up Hitler. Killing the baby eliminates that future.
There could be other babies that can also grow up to be future Hitlers. So let's say 4 such babies exist. By killing one I eliminated 1/4 for futures with Grown up Hitlers that exist.
This whole thread is getting flagged. Likely by an irrational parent who can't even compute natural selection, babe, and Hitler all in a single paragraph.
Re: Baby is healed with first personalized gene-editing treatment
#135> To accomplish that feat, the treatment is wrapped in fatty lipid molecules to protect it from degradation in the blood on its way to the liver, where the edit will be made. Inside the lipids are instructions that command the cells to produce an enzyme that edits the gene. They also carry a molecular GPS — CRISPR — which was altered to crawl along a person’s DNA until it finds the exact DNA letter that needs to be c…
> That is one of the most incredible things I have ever read. This is even more great reading behind the above: https://en.wikipedia.org/wiki/Jennifer_Doudna
Walter Isaacson's book "The Code Breaker" is about this subject. I couldn't put it down.
Re: Baby is healed with first personalized gene-editing treatment
#136NYT isn’t super specific here, but they made it sound like the disease treated is liver related. My understanding is that the liver is a good place to start with CRISPR-type gene treatments, in that the liver normally deals with anomalous shit in your bloodstream, say, like CRISPR type edits. So anywhere outside the liver is going to be significantly harder to get really broad uptake of gene edits. It’s crazy encoura…
You are right, current CRISPR systems tends to accumulate in the liver. Most CRISPR companies have shifted their focus to the liver over time because it's easiest to deliver there. Most viruses people use to target other organs are not large enough to carry CRISPR and lipid nanoparticles with CRISPR seem to like ending up in the liver and are hard to deliver at dose to hit other organ systems. It has been one of the big struggles of CRISPR companies. That being said, this is a huge deal and very encouraging.
As to the FDA stance, it tends to be more willing to go ahead with compassionate uses like this when it's clearly life or death.[1]
[1] https://www.statnews.com/2025/05/15/crispr-gene-editing-land... This discuss a little of the FDA stuff but not much more detail, it sounds like they did let them skip some testing.
Re: Baby is healed with first personalized gene-editing treatment
#137[flagged]
Re: Baby is healed with first personalized gene-editing treatment
#138I wonder if this also affects germline cells so he won't pass the same disease on to his children. If it does, that would be a complete departure from almost all medical treatments we use because most of them are just compensating for the effects of bad genes and leaving them in the gene pool to degrade the health of future generations.
Re: Baby is healed with first personalized gene-editing treatment
#139Earlier quoted context omitted.
Made it sound like it's a computer, is it Turing complete?
Made me think of It was only in college, when I read Douglas Hofstadter’s Gödel, Escher, Bach, that I came to understand cells as recursively self-modifying programs. The language alone was evocative. It suggested that the embryo—DNA making RNA, RNA making protein, protein regulating the transcription of DNA into RNA—was like a small Lisp program, with macros begetting macros begetting macros, the source code contain…
>> Imagine a flashy spaceship
I misread this as "fleshy" for a moment, and the quote almost works better that way.
Re: Baby is healed with first personalized gene-editing treatment
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