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Dopamine signals when a fear can be forgotten

picower.mit.edu

31–40 of 140 posts

Re: Dopamine signals when a fear can be forgotten

#31
post #19

Incoming cocaine therapy! Seriously though as someone who suffers from extreme anxiety I am eternally grateful for this kind of work. I would really like to see this combined with brain stimulation.

What’s interesting here is that in the drug treatment world it’s basically known that drug abuse is almost always a reaction to some kind of psychological trauma or disorder, and an awful lot of drugs (not just cocaine) play heavily with the dopamine pathways. The idea of dopamine as your brain’s signal that you’re safe fits about as neatly with that as can be. (Of course, like everything in biology, dopamine also do…

I had the unique experience as a youth in attending a school where a substantial portion of the school was funneled there by one of the many 1970s and 1980s troubled teen corporations that spun out of Synanon after it collapsed. This one specialized in drug addicts.

Almost all of my classmates (not me, unfortunately) were from exceptionally wealthy families and excepting one none of them ever mentioned any childhood trauma. Instead they were precocious partiers who got into drugs despite being underage and going to the nightclubs in the seedy part of town - no one at the time was turning away hot young women or gay(for pay or real) young men. And the club scene was a drug scene. It still is.

I don’t think trauma is actually at the root of almost all drug abusers. The only first class abusers (pot and alcohol in serious quantities daily) that I know at the moment grew up in perfectly fine suburban families and are in good, non-narcissistic/controlling/etc relationships with their families. They’re just addicts who can’t stop. One of them is going to die from it, eventually, given his level of alcohol consumption.

Re: Dopamine signals when a fear can be forgotten

#32
post #16
post #5

I have a simple question. How do I control dopamine in "my" brain so that I can focus on "here and now" instead of HN and GitHub.

1. Cold plunge - high but transient (last for hours). I do it in the morning, after my shower - start the day off right. 2. Exercise - short-term: increases dopamine, serotonin, and a bunch of other good stuff; long-term: increases dopamine receptor density. 3. Caffeine - while doesn't technically increase dopamine, it blocks adenosine receptors which indirectly increases dopamine signalling. But habitual use blunts…

Nicotine.

Re: Dopamine signals when a fear can be forgotten

#33

Incoming cocaine therapy! Seriously though as someone who suffers from extreme anxiety I am eternally grateful for this kind of work. I would really like to see this combined with brain stimulation.

I would unironically say this is the how of how adderall works for me.

I am distracted from work by anxiety. With medication, I'm not distracted.

Re: Dopamine signals when a fear can be forgotten

#34
post #5

I have a simple question. How do I control dopamine in "my" brain so that I can focus on "here and now" instead of HN and GitHub.

Go see if you’re ADD/ADHD and get on meds (I recommend Dexedrine), then also “join” the neurospicey community spaces where people swap tips, learnings and observations.

Also always go for a walk, touch grass, hug a tree. Pleasant physical experiences are truly effective at getting you into the “here and now”.

Re: Dopamine signals when a fear can be forgotten

#35
This line in the article is horrifying:

> The researchers were surprised that when they activated VTA dopaminergic inputs into the aBLA they could reinstate fear even without any new foot shocks, impairing fear extinction.

That... seems like the first step in being able to literally induce fear without having to bother with pesky things like finding the subject's triggers. Although I suppose if one has direct access to the subject's amygdala, the point is somewhat moot.

Still, it's sort of like a reverse wirehead.

https://en.wikipedia.org/wiki/Wirehead_(science_fiction)

Re: Dopamine signals when a fear can be forgotten

#36

Incoming cocaine therapy! Seriously though as someone who suffers from extreme anxiety I am eternally grateful for this kind of work. I would really like to see this combined with brain stimulation.

I would unironically say this is the how of how adderall works for me. I am distracted from work by anxiety. With medication, I'm not distracted.

Generic Adderall Gang here, and in hindsight, I'm surprised at how little of it I need to realize a much better headspace. Makes me wonder if all of that caffeine in my undiagnosed youth was saying something...

Re: Dopamine signals when a fear can be forgotten

#37
post #10
post #5

I have a simple question. How do I control dopamine in "my" brain so that I can focus on "here and now" instead of HN and GitHub.

Strengthen your prefrontal cortex so "you" have more control over your urges. You typically do this with meditation.

This was an interesting connection to me between meditation and neuroscience. Buddhists talk about the "monkey mind" that chatters incessantly. Well, that's the default mode network, part of your brain that is active when you're not engaged in a specific task, when you're thinking about self, others, past or future. A useful adaptation in our past environment for sure, but overactivity can be detrimental. The Buddhist solution is to mediate, to focus the attention on a singular thing and not be distracted by the chatter. That ability lives in the prefrontal cortex! It's able to override the DMN and it's something that can be trained by just exercising it.

Re: Dopamine signals when a fear can be forgotten

#38

Earlier quoted context omitted.

Or you just set a firewall and block these 2 websites ^^ (Welcome to the club)

Your firewall seems broken.

Maybe they are texting from the embedded browser in their car's infotainment system? Never underestimate the creativity of a procrastinator.

Re: Dopamine signals when a fear can be forgotten

#39
post #16
post #5

I have a simple question. How do I control dopamine in "my" brain so that I can focus on "here and now" instead of HN and GitHub.

1. Cold plunge - high but transient (last for hours). I do it in the morning, after my shower - start the day off right. 2. Exercise - short-term: increases dopamine, serotonin, and a bunch of other good stuff; long-term: increases dopamine receptor density. 3. Caffeine - while doesn't technically increase dopamine, it blocks adenosine receptors which indirectly increases dopamine signalling. But habitual use blunts…

I have found l-tyrosine also being quite helpful when taken occasionally.

Re: Dopamine signals when a fear can be forgotten

#40

Earlier quoted context omitted.

I would unironically say this is the how of how adderall works for me. I am distracted from work by anxiety. With medication, I'm not distracted.

Generic Adderall Gang here, and in hindsight, I'm surprised at how little of it I need to realize a much better headspace. Makes me wonder if all of that caffeine in my undiagnosed youth was saying something...

I'd be interested in your thoughts more here.

The problem with amphetamine is you pay for every benefit: focus now, lethargy later; energy now, anhedonia later.

But taking a small, consistent dose. Does that work? Do you feel you net benefits in life from taking the drug, discounting for withdrawal and/or tolerance?

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