Adipose tissue retains an epigenetic memory of obesity after weight loss

Post by taeric » Thu, Apr 17, 2025, 6:18 PM UTC

bluecheese452 wrote: post #224

taeric wrote: post #127

Earlier quoted context omitted.

I would slightly tweak your last. Different nutrients (vitamins/whatever) also impact your body in specific ways. Not just "makes you healthy" but "causes you to do certain things." Caffeine is the easy example here. This gets back to the "feedback loops" above. There are certainly feedback loops. But you are unlikely to be able to prime any of them by just increasing an input. And increasing output is something you…

We cannot make that claim with relative certainty. We cannot make the opposite claim either, but it is more likely.

Post by djmips » Thu, Apr 17, 2025, 6:28 PM UTC

e40 wrote: post #116

spoiler wrote: post #2

As someone who's struggled with weight loss, and have known others to struggle with it well, I think we colloquially called this "slow metabolism". It always did feel like it was easier to gain weight than lose it, especially fat weight and not muscle weight for me. I was recently sent a video about fat adaptation (basically teaching your body to be better at burning fat) by a very fit friend, but I wonder how much o…

For me, sugar was the reason I couldn't lose weight. I got a CGM (continuous glucose monitor) and got my blood sugar under control, and with very little effort I lost a lot of weight. I use 90% cacao Lindt to control my sweet tooth. 1/2 the bar has 4g of sugar, and I consume it over hours. It also has the side effect of reducing my hunger. If you eat much of 90% chocolate, it makes you feel nausea. The trick is to pu…

Post by [deleted] » Thu, Apr 17, 2025, 6:40 PM UTC

jdhendrickson wrote: post #181

__float wrote: post #154

Earlier quoted context omitted.

He has surely dedicated a significant portion of his life to his own pet theories on obesity, but to consider him a well-regarded expert is very misleading. He has quite a few claims that are just...ridiculous, and his pop science books have some serious flaws (as reported by actual experts).

While I don't doubt you, it would be helpful if you cited these experts, so people can learn.

Post by meindnoch » Thu, Apr 17, 2025, 6:43 PM UTC

sleepyguy wrote: post #158

phkahler wrote: post #108

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>> But when you lose weight, they don't apoptose Googled for "Adipocyte apoptosis" and oh boy... It does happen, but I don't trust the AI summary. This looks like a deep rabbit hole.

It seems fasting causes Adipocyte apoptosis. It makes sense, there is cell death. I lost 100 lbs fasting over 1.5 years. I did gain some weight back after stopping, but not much. Strangely, where I saw fat return was not where most of it came off.

Post by djmips » Thu, Apr 17, 2025, 6:45 PM UTC

e40 wrote: post #202

nfg wrote: post #192

Earlier quoted context omitted.

I’d be interested to hear more here - what CGM did you buy? What was your process for monitoring?

The Stelo. 2 for $99. Oddly, it shipped from Amazon but Amazon doesn't sell them. The app is subpar on iOS, but if you give Apple's Health app permission, you can get more data in there. Graphs that have absolute numbers. I think they reason their app doesn't give absolute values (for historical values, they give the current value only), is because it's not a calibrated device. It can't be used to control an insulin…