Since I had to look it up:
"Adipose tissue" means "fat tissue".
Adipose tissue retains an epigenetic memory of obesity after weight loss
101–110 of 343 posts
Re: Adipose tissue retains an epigenetic memory of obesity after weight loss
#102Well, yeah. Adipocytes multiply when you get fat. But when you lose weight, they don't apoptose, they just shrink in volume by giving up their lipid stores.
I am pretty sure the only way to reduce the number of cells is liposuction
Re: Adipose tissue retains an epigenetic memory of obesity after weight loss
#103Earlier quoted context omitted.
It's not about the weight, it's about the exercise. Start with something easy and establish a rule that won't ever be broken. If you break a rule once, you'll lose the fight. My rule, for example, when I started to train more: - start with 10 crunches every morning and evening - increase by 2 crunches every day - no exceptions When you are at ~2 months in, you can add weight training to it to get stronger. Additional…
Have you actually lost weight like that? I think exercise is a huge trap for weight loss. Cardio exercise makes you healthy, but it will also make you hungry. Especially if you are not used to it. Overweight people are usually already overeating. They can't deal with hunger and cravings well. If you make them do cardio, they will likely eat back whatever they burned and most likely much more. And even if they don't,…
> Cardio exercise makes you healthy, but it will also make you hungry.
That's what I've noticed, too.
But I've also noticed that it makes me crave different foods than when I sit on my ass all day. So, on average, I tend to actually eat less, because I don't have random cravings in between meals.
I doubt that people who are overweight and sedentary only eat "healthy" meals, only too much.
Re: Adipose tissue retains an epigenetic memory of obesity after weight loss
#104As someone who's struggled with weight loss, and have known others to struggle with it well, I think we colloquially called this "slow metabolism". It always did feel like it was easier to gain weight than lose it, especially fat weight and not muscle weight for me. I was recently sent a video about fat adaptation (basically teaching your body to be better at burning fat) by a very fit friend, but I wonder how much o…
>but I wonder how much of that is bro science and how much of it is grounded in reality
It's probably bro science or contributing a small amount to any effort. The biggest problem is the food industry serving shit in large portions, which can be hard for populations to psychologically resist (see: America). Most things in the grocery store are shit too.
I don't think you can effectively teach people to resist it though, you'd have to get rid of the shit being there so it's not even an option.
Re: Adipose tissue retains an epigenetic memory of obesity after weight loss
#105I always used to think negatively about people that were severely overweight (still do unconsciously if I'm being honest) as I always attributed their obesity to lack of will power. I'm a huge proponent of better living through chemistry (steroids - with frequent blood work, nootropics, whatever) and recently I decided to get my abs back. I hopped on some compounded semiglutide and was blown away by the change in my…
I had this same experience, but I have not continued to take the medication after a short experiment. I found I could get a similar outcome (subjective experience) through my food selection Today I’ve eaten around 2kg of vegetables today (zucchini, capsicum, eggplant, cauliflower, spinach) all of which was under 500 calories, and I’ve eaten fish. If I eat a massive amount of vegetables and get ~200g protein, I don’t…
My brother's family has done something similar although in a different direction. They have been strictly carnivore for several years now. Able to eat large amounts of food while keeping calories low and feeling satiated. It's worked well for them.
I'll look at that study you mentioned, thank you.
Re: Adipose tissue retains an epigenetic memory of obesity after weight loss
#106Well, yeah. Adipocytes multiply when you get fat. But when you lose weight, they don't apoptose, they just shrink in volume by giving up their lipid stores.
I am pretty sure the only way to reduce the number of cells is liposuction
Worse than that. Subcutaneous fat (which is the one you can trim off with liposuction) usually expands relying more in cell expansion and not in hyperplasia. Visceral fat on the other hand, is way more likely to involve hyperplasia and you cannot use liposuction against this type of fat. This is also the fat that is very hormonally active and increases the risks of diabetes, heart disease, cancers, strokes.
Re: Adipose tissue retains an epigenetic memory of obesity after weight loss
#107Well, yeah. Adipocytes multiply when you get fat. But when you lose weight, they don't apoptose, they just shrink in volume by giving up their lipid stores.
Yea, this actually explains the transcriptional expression and weight gain very well. Strong than the methylation evidence imo. I didn’t see any causal analysis only correlated and the cells still being there makes sense.
Re: Adipose tissue retains an epigenetic memory of obesity after weight loss
#108Well, yeah. Adipocytes multiply when you get fat. But when you lose weight, they don't apoptose, they just shrink in volume by giving up their lipid stores.
>> But when you lose weight, they don't apoptose
Googled for "Adipocyte apoptosis" and oh boy... It does happen, but I don't trust the AI summary. This looks like a deep rabbit hole.
Re: Adipose tissue retains an epigenetic memory of obesity after weight loss
#109Earlier quoted context omitted.
I think you need to make it sustainable. I never had to do it consistently but even I know... Nobody is going to live hungry all the time. Nobody is going to grow old counting calories every damn day. So rather than just eating less make sure to work out some. Consistently. Id suggest strength training. I did a full body strength training workout 2-3 times a week. Some may suggest doing leg days, arm days, etc but go…
This is advice people often give, but unfortunately it's wrong. Exercise and working out are useful and healthy, but it's not a sufficient tool for losing weight in most situations. The core problem is that the amount of calories you eat is in the ballpark of thousands, while a workout will burn in the order of hundreds (excluding athletes and such). This along with metabolic adaptation means that it's always easier…
Yes. One summer my friends asked me to join in a running program with them. We went from basically sedentary to running 5k a day within several weeks. They hoped to lose weight. I didn't expect to, because we weren't eating any differently, but I did it because I wanted to get stronger and less out-of-breath.
I was right; we didn't lose any weight, but we did get much better at running without gasping to a stop within a couple minutes.
Re: Adipose tissue retains an epigenetic memory of obesity after weight loss
#110Well, yeah. Adipocytes multiply when you get fat. But when you lose weight, they don't apoptose, they just shrink in volume by giving up their lipid stores.
I am pretty sure the only way to reduce the number of cells is liposuction
I've been wondering about that. Like all cosmetic surgery liposuction is looked down upon.
But maybe it can also be a useful and healthy weight loss strategy?