As someone who's struggled with weight loss, and have known others to struggle with it well, I think we colloquially called this "slow metabolism". It always did feel like it was easier to gain weight than lose it, especially fat weight and not muscle weight for me. I was recently sent a video about fat adaptation (basically teaching your body to be better at burning fat) by a very fit friend, but I wonder how much o…
Adipose tissue retains an epigenetic memory of obesity after weight loss
11–20 of 343 posts
Re: Adipose tissue retains an epigenetic memory of obesity after weight loss
#12Just went trough Yo-Yo. Any good strategies on how to overcome it for good?
Re: Adipose tissue retains an epigenetic memory of obesity after weight loss
#13Just went trough Yo-Yo. Any good strategies on how to overcome it for good?
Re: Adipose tissue retains an epigenetic memory of obesity after weight loss
#14> ...it is plausible that epigenetic memory could also play a role in many other contexts, including addictive diseases. Recent advancements in targeted epigenetic editing global remodelling of the epigenome provide promising new approaches. "Darn, I think I've contracted some alcoholism. Could you order me another bottle of the reset pills?"
Re: Adipose tissue retains an epigenetic memory of obesity after weight loss
#15> ...it is plausible that epigenetic memory could also play a role in many other contexts, including addictive diseases. Recent advancements in targeted epigenetic editing global remodelling of the epigenome provide promising new approaches. "Darn, I think I've contracted some alcoholism. Could you order me another bottle of the reset pills?"
Re: Adipose tissue retains an epigenetic memory of obesity after weight loss
#16> ...it is plausible that epigenetic memory could also play a role in many other contexts, including addictive diseases. Recent advancements in targeted epigenetic editing global remodelling of the epigenome provide promising new approaches. "Darn, I think I've contracted some alcoholism. Could you order me another bottle of the reset pills?"
More like "just take these GLP-1 agonists for the rest of your life". Those seem to have an effect on addictions etc. But at least when it comes to weight, people seem to put it back on once they quit. Perhaps the GLP-1 agonist is lacking an epigenetic reset button ...
If you come off it before that 5 years are up, yeah, you are probably expected to bounce back somewhat.
You might not need to be on GLP-1 forever, but you might need to be on it longer than people currently think.
Re: Adipose tissue retains an epigenetic memory of obesity after weight loss
#17Just went trough Yo-Yo. Any good strategies on how to overcome it for good?
food is no longer a reward for anything
fin.
Re: Adipose tissue retains an epigenetic memory of obesity after weight loss
#18Earlier quoted context omitted.
More like "just take these GLP-1 agonists for the rest of your life". Those seem to have an effect on addictions etc. But at least when it comes to weight, people seem to put it back on once they quit. Perhaps the GLP-1 agonist is lacking an epigenetic reset button ...
Fat cells only turn over about 20% per year. You basically need to maintain a reduced weight for 5 years before the fat cells "forget" the higher weight. If you come off it before that 5 years are up, yeah, you are probably expected to bounce back somewhat. You might not need to be on GLP-1 forever, but you might need to be on it longer than people currently think.
Re: Adipose tissue retains an epigenetic memory of obesity after weight loss
#19Re: Adipose tissue retains an epigenetic memory of obesity after weight loss
#20The more you research/learn about obesity, the worse it is, much like smoking. One of the most depressing stats is that dieting does not get easier with time. The probability of eventually regaining all the weight eventually converges to 100%. Even if you're successful for 2 years, people still regain by year 4, 5, etc. The body never resists trying to regain the weight. GLP-1 drugs are the best hope yet.