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Antiviral chewing gum to reduce influenza and herpes simplex virus transmission

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Re: Antiviral chewing gum to reduce influenza and herpes simplex virus transmission

#42

Earlier quoted context omitted.

Annoyed at how the guidance has changed on this over the years. At first it was just a narrow slice of 20 something women. Then girl teenagers. Then men and women under 30. Then under 40. If it has an association with preventing cancers, not sure why they were so reluctant to immediately open up the patient pool.

I am not sure why all the replies are indicating you are anti-science or anti-vax. It is annoying to be told something from your doctor, internalize it, have your doctor suggest flu and covid vaccine for years but never HPV, and then be told on HackerNews "you should have the HPV" and now I am supposed to tell my doctor I can do his job better than him because I read something on the internet even though most doctors…

In the United States, you are in trouble if you don’t advocate for your own health.

Re: Antiviral chewing gum to reduce influenza and herpes simplex virus transmission

#43
post #40

Earlier quoted context omitted.

Either the vaccine has notable safety issues or it should be at least fine to get the vaccine at an older age. The reason many people don't trust the CDC's advice is they don't really tell you why or why not. If you're over 26 you're pretty likely to already be exposed to HPV but not necessarily every strain which would be protected by the vaccine (as it says in the article). So this pushes the question: why shouldn'…

Vaccine recommendations are based on more than just safety. Efficacy, cost, availability, and prioritization are also considerations. > Compared with the benefit of the existing HPV vaccination program for adolescents and young adults through age 26 years, the additional benefit of vaccinating people age 27 through 45 years would be minimal. > Given abundant evidence for safety of HPV vaccines, undesirable anticipate…

Yeh. The NHS has a pretty focussed set of criteria https://www.nhs.uk/vaccinations/hpv-vaccine/

Re: Antiviral chewing gum to reduce influenza and herpes simplex virus transmission

#44
post #2

PSA, everyone should be getting the HPV vaccine, regardless of age and gender. https://en.wikipedia.org/wiki/HPV_vaccine https://www.mdanderson.org/publications/focused-on-health/wh... https://www.cdc.gov/cancer/hpv/oropharyngeal-cancer.html

Annoyed at how the guidance has changed on this over the years. At first it was just a narrow slice of 20 something women. Then girl teenagers. Then men and women under 30. Then under 40. If it has an association with preventing cancers, not sure why they were so reluctant to immediately open up the patient pool.

With regards to HPV, when they tried recommmending (and even making it mandatory) for young print the Christian-right cried foul pretty hard. The Texas Governor got a heap of shit over it at the time because abstinence is the only thing teenagers should know about.

Re: Antiviral chewing gum to reduce influenza and herpes simplex virus transmission

#45

Earlier quoted context omitted.

Annoyed at how the guidance has changed on this over the years. At first it was just a narrow slice of 20 something women. Then girl teenagers. Then men and women under 30. Then under 40. If it has an association with preventing cancers, not sure why they were so reluctant to immediately open up the patient pool.

I am not sure why all the replies are indicating you are anti-science or anti-vax. It is annoying to be told something from your doctor, internalize it, have your doctor suggest flu and covid vaccine for years but never HPV, and then be told on HackerNews "you should have the HPV" and now I am supposed to tell my doctor I can do his job better than him because I read something on the internet even though most doctors…

Becoming a doctor in America requires studying 1 semester of statistics which can have been satisfied by a passing score on an AP statistics exam in high school, years before entering practices. The only thing you know about an MD is they got a C or better in biology and organic chemistry at some point, then tolerated years of abuse to get admitted to the guild. There is really no reason at all to believe that a typical MD knows how to interpret medical literature better or even as well as you can.

Re: Antiviral chewing gum to reduce influenza and herpes simplex virus transmission

#46
post #2

PSA, everyone should be getting the HPV vaccine, regardless of age and gender. https://en.wikipedia.org/wiki/HPV_vaccine https://www.mdanderson.org/publications/focused-on-health/wh... https://www.cdc.gov/cancer/hpv/oropharyngeal-cancer.html

While this advice is good, the article is discussing HSV (herpes simplex virus), not HPV (human papilloma virus), which have quite different symptoms and epidemiology. There are, as yet, no approved HSV vaccines.

Second part of the PSA, one should keep prophylactic antiviral medication on hand incase you get exposed to someone with HSV. With 60% of the population positive for HSV, everyone should have an antiviral on hand. acyclovir, famciclovir and valaciclovir

https://www.ncbi.nlm.nih.gov/books/NBK525787/

Re: Antiviral chewing gum to reduce influenza and herpes simplex virus transmission

#47
post #2

PSA, everyone should be getting the HPV vaccine, regardless of age and gender. https://en.wikipedia.org/wiki/HPV_vaccine https://www.mdanderson.org/publications/focused-on-health/wh... https://www.cdc.gov/cancer/hpv/oropharyngeal-cancer.html

Annoyed at how the guidance has changed on this over the years. At first it was just a narrow slice of 20 something women. Then girl teenagers. Then men and women under 30. Then under 40. If it has an association with preventing cancers, not sure why they were so reluctant to immediately open up the patient pool.

> If it has an association with preventing cancers, not sure why they were so reluctant to immediately open up the patient pool.

Multiple reasons.

The first one is basic ethics. Similar on how you should do rolling upgrades of your SaaS software to catch errors before everything goes down, you got to do the same with vaccines. For there, go for the target group with the highest risk and highest potential of averting damage - and for the HPV vaccine, mid-20 women are the best such group: young enough that they might be lucky and not exposed yet, old enough to fall out of the scope of the usual ethics bureaucracy that (rightfully) comes with doing experimental research involving minors, and not so old that they definitely got exposed and making the effort moot. Then it got rolled out to teenage girls as it was proven safe, and eventually to men as well because we can be asymptomatic carriers (as we are for a lot of STDs).

Obviously if you got the speed of Covid vaccines in mind as a comparison, the HSV vaccine appears slow in rollout speed - but please do not forget, the Covid vaccines went through very speedy trials. We were extremely lucky it worked out the way it did.

The second one is availability. Again, unless it's Covid where everything went into full production power in a matter of months, production has to be ramped up carefully, matching rollout strategies - it doesn't make sense to have a mismatch into either direction.

And the third one is time. With Covid, it was easy to prove effectiveness: the people that got the shot got Covid at waaaay lower rates than the control population (and the risks of side effect were way less than the risk of severe Covid). But with something like HPV that can have years if not decades worth of time between exposure and symptoms, it becomes harder to reasonably judge effectiveness and safety.

Re: Antiviral chewing gum to reduce influenza and herpes simplex virus transmission

#48
post #2

PSA, everyone should be getting the HPV vaccine, regardless of age and gender. https://en.wikipedia.org/wiki/HPV_vaccine https://www.mdanderson.org/publications/focused-on-health/wh... https://www.cdc.gov/cancer/hpv/oropharyngeal-cancer.html

> PSA, everyone should be getting the HPV vaccine, regardless of age and gender. This is false, please don't take medical advice from an HN post. CDC guidelines do include quite a bit of discussion of patient age. [1] 1. https://www.cdc.gov/vaccines/vpd/hpv/hcp/recommendations.htm...

Yeah, and masks don't work. If it is recommended for adults aged 45, when you turn 46, it kills you.

Re: Antiviral chewing gum to reduce influenza and herpes simplex virus transmission

#49
post #2

PSA, everyone should be getting the HPV vaccine, regardless of age and gender. https://en.wikipedia.org/wiki/HPV_vaccine https://www.mdanderson.org/publications/focused-on-health/wh... https://www.cdc.gov/cancer/hpv/oropharyngeal-cancer.html

> PSA, everyone should be getting the HPV vaccine, regardless of age and gender. This is false, please don't take medical advice from an HN post. CDC guidelines do include quite a bit of discussion of patient age. [1] 1. https://www.cdc.gov/vaccines/vpd/hpv/hcp/recommendations.htm...

Thats nonsense. Their "recommendation" is based on supply and epidemiological trends, not actual need of the drug. If supply gets constrained, its up to the CDC and drug makers to make more, not to tell the population to limit uptake.

This is why I don't trust CDC guidelines, nor doctors who blindly parrot them without explanation or context.

Sure, check with "your doctor" about the vaccine. If they give you no good reason not to take it, then take it.

Re: Antiviral chewing gum to reduce influenza and herpes simplex virus transmission

#50

Earlier quoted context omitted.

Medical ethics focus on the benefit to a specific individual - your patient. This defuses the "Should I kill one to save ten?" moral dilemma - the individual is your patient, even if the other ten are also your patients, you must not harm the one. But for vaccines it also means that the wider societal implications are not ethically relevant So, medics won't recommend that you give patient A an intervention which is o…

You're not wrong about ethical considerations, but the CDC operates socially and politically as well. Back when the vaccine was new, an objection from some parents was that the vaccine might be viewed as a license or permission for their daughters to be promiscuous. There was a substantial headwind. The public wasn't yet generally aware that HPV could cause head, neck, and anal cancers in men. If a doctor approached…

What is it with people about the false ethics and recommendation around efficacy this and some bs calculus. The downsides are miniscule, the upsides are reduced cancers across the board.

I just had a doctor offer the HPV vaccine for my daughter as optional, 1, I thought we had already gotten it (my bad) because we ask for all the vaccines and 2, anal, throat and neck cancer. There are many scenarios where HPV could be contracted that aren't voluntary. But preventing HPV is.

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