I don't think a new distro is needed. Most commonly used windows apps can be made to work through wine, but the hacks used to make one app work can break others and vice versa. Similarly, everyone needs to play around with settings individually to get things to work. What works on one person's machine might not work on another's, because there's no consistency in, effectively, configuration.
The simplest solution, to me, is to just distribute containers (or some other sandbox) with wine in it, and the necessary shenanigans to get the windows program (just the one) working in the container, and just distribute that. Everyone gets the same artifact, and it always works. No more dicking around with wine settings, because it's baked in for whatever the software is.
Yes, this is tremendously space inefficient, so the next step would be a way of slimming wine down for container usage.
The only real barrier to this system is licensing and software anti patterns. You might have to do some dark magic to install the software in the container in the first place.