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The Ozempocalypse Is Nigh

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11–20 of 97 posts

Re: The Ozempocalypse Is Nigh

#11

Earlier quoted context omitted.

Few people actually pay 1000/month. Most get it through insurance (I pay 25/month), and most of the remaining get it through compounding pharmacies like HenryMeds which comes out to 300-400 per month. In fact, I know a few people who get brand pills (Rybelsus) mailed from India, where it's much cheaper. This insane pricing is a US only thing.

Rybelsus doesn’t work.

Of course it does, it is just much less effective than the injectable versions.

Re: The Ozempocalypse Is Nigh

#12
post #4
post #2

Can someone please explain the economics of GLP-1s? How can people pay $1000/month for the rest of their life, just to keep weight off? Rent and mortgages are already insane as is, and then there’s insurance, kids, etc.

Knowing a couple people who've done it, they do it for a few months to lose weight, then stop taking it and try not to gain the weight back. I don't know anyone who's chosen to go on it permanently.

The drugs have been cheaply and widely available for a little over 17 months, and by some measures, about 1/3rd of patients prescribed semaglutide or tirzepatide are forecasted to be using either permanently.

Re: The Ozempocalypse Is Nigh

#13

I'm far from convinced that some random "compounding pharmacy" produces effectively the same thing as Ozempic.

Compounding pharmacies existed before Ozempic and their entire business model is producing custom drugs at reasonable prices. For Ozempic, they order the GLP-1 peptides from a large Pharma company and then mix it to order with bacteriostatic water and any other additives. Mine includes a B-12 compound that is attempting to help with the weight loss. They are highly regulated and require trained and licensed employees. The compounding pharmacies I don't trust are the ones that only started to do Ozempic and nothing else. But I do trust my local one. They've made me medication for my animals for decades now.

Re: The Ozempocalypse Is Nigh

#15
post #4
post #2

Can someone please explain the economics of GLP-1s? How can people pay $1000/month for the rest of their life, just to keep weight off? Rent and mortgages are already insane as is, and then there’s insurance, kids, etc.

Knowing a couple people who've done it, they do it for a few months to lose weight, then stop taking it and try not to gain the weight back. I don't know anyone who's chosen to go on it permanently.

I'm doing essentially right now. Not big by any means, but loosing 20 to 30 pounds would be amazing for my joints.

For me, I've been at a stable weight for over a decade. I figure if I can drop down over a few months, I can stay at my target weight.

Re: The Ozempocalypse Is Nigh

#16
post #2

Can someone please explain the economics of GLP-1s? How can people pay $1000/month for the rest of their life, just to keep weight off? Rent and mortgages are already insane as is, and then there’s insurance, kids, etc.

I can afford 1k/month and will if that's what's required. My life is well over 1k/month better with a healthier weight. I preform better at work, I'm happier, and I should live longer. That's worth the money.

Re: The Ozempocalypse Is Nigh

#17
The status quo was pretty good for the FDA. Lily and Novo Nordisk still saw major stock price rises. Patients had super cheap drug options for something that would free up lots of money for non-medical spending in the economy. Why does an administration ruling via EO not keep the compounding loophole? It aligns with their goals. IMO, the compounders need to turn this into a media sound bite sized win for politicians. Because it certainly doesn’t make any scientific or objective medical sense to cease the compounding.

Re: The Ozempocalypse Is Nigh

#18

I'm far from convinced that some random "compounding pharmacy" produces effectively the same thing as Ozempic.

The thing is, GLP-1 isn't that hard to make, and these compounding pharmacies make effectively the real thing.

Even further, most drugs aren't _that hard_ to manufacturer.

The hard part is discovering them and proving they're safe and effective.

Re: The Ozempocalypse Is Nigh

#19
post #2

Can someone please explain the economics of GLP-1s? How can people pay $1000/month for the rest of their life, just to keep weight off? Rent and mortgages are already insane as is, and then there’s insurance, kids, etc.

1) Any number of ways, they don’t pay that much. Or,

2) They’re rich. Not even that rich. I mean hell we paid $1,500/month for two kids to go to preschool, for years, and that sucked but we could still save. And we had a household income of like $130k or so at the time. Doing fine, not saying we didn’t have alright income, but not that uncommon. Now imagine a two-FAANG income like many folks on here. $1,000/month, even times two, is entirely within reach for them. Also,

3) You can go off it for periods and just go back on if the weight starts to creep up. Anyone who’s successfully maintained weight for periods in the past may be able to manage long stretches without it and not gain much. And further,

4) It’s not going to cost that much for long, in the scheme of things. The price will likely settle in the tens of dollars per month when the patents expire.

Re: The Ozempocalypse Is Nigh

#20
post #2

Can someone please explain the economics of GLP-1s? How can people pay $1000/month for the rest of their life, just to keep weight off? Rent and mortgages are already insane as is, and then there’s insurance, kids, etc.

People who need statins are on them for the rest of their life. People who need blood pressure regulators are on them for the rest of their life.

Why should GLP-1s be any different?

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